{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:16:54Z","timestamp":1790723814929,"version":"4.1.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"DOI":"10.3389\/fmed.2025.1631671","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T05:25:47Z","timestamp":1754630747000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Combining multimodal medical imaging and artificial intelligence for the early diagnosis of pancreatic cancer"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiaoli","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6931","DOI":"10.7150\/thno.77949","article-title":"Artificial intelligence in pancreatic cancer","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics."},{"key":"B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin."},{"key":"B3","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00423-020-01980-2","article-title":"Role of lymphadenectomy in resectable pancreatic cancer","volume":"405","author":"Erdem","year":"2020","journal-title":"Langenbecks Arch Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.3748\/wjg.v29.i12.1811","article-title":"Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis","volume":"29","author":"Faur","year":"2023","journal-title":"World J Gastroenterol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"20TR01","DOI":"10.1088\/1361-6560\/ab843e","article-title":"Deep learning in medical image registration: a review","volume":"65","author":"Fu","year":"2020","journal-title":"Phys Med Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","article-title":"Radiomics: extracting more information from medical images using advanced feature analysis","volume":"48","author":"Lambin","year":"2012","journal-title":"Eur J Cancer Oxf Engl 1990."},{"key":"B7","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1159\/000161009","article-title":"Long-term survival and prognostic indicators in small (< or=2 cm) pancreatic cancer","volume":"8","author":"Pongprasobchai","year":"2008","journal-title":"Pancreatology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"7556","DOI":"10.1007\/s00330-023-09768-w","article-title":"Assessment of radiomics research (ARISE): a brief guide for authors, reviewers, and readers from the scientific editorial board of European radiology","volume":"33","author":"Kocak","year":"2023","journal-title":"Eur Radiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.ultrasmedbio.2007.09.018","article-title":"Utility of contrast-enhanced endoscopic ultrasonography for diagnosis of small pancreatic carcinomas","volume":"34","author":"Sakamoto","year":"2008","journal-title":"Ultrasound Med Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.giec.2015.06.011","article-title":"Diagnosing biliary malignancy","volume":"25","author":"Xu","year":"2015","journal-title":"Gastrointest Endosc Clin N Am."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14309\/ctg.0000000000000045","article-title":"Usefulness of deep learning analysis for the diagnosis of malignancy in intraductal papillary mucinous neoplasms of the pancreas","volume":"10","author":"Kuwahara","year":"2019","journal-title":"Clin Transl Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.gie.2010.06.042","article-title":"Differential diagnosis of pancreatic cancer from normal tissue with digital imaging processing and pattern recognition based on a support vector machine of EUS images","volume":"72","author":"Zhang","year":"2010","journal-title":"Gastrointest Endosc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"17562848221093873","DOI":"10.1177\/17562848221093873","article-title":"Application of artificial intelligence in diagnosis of pancreatic malignancies by endoscopic ultrasound: a systemic review","volume":"15","author":"Goyal","year":"2022","journal-title":"Ther Adv Gastroenterol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1055\/a-1873-7920","article-title":"Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses","volume":"55","author":"Kuwahara","year":"2022","journal-title":"Endoscopy."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1038\/s41591-023-02640-w","article-title":"Large-scale pancreatic cancer detection via non-contrast CT and deep learning","volume":"29","author":"Cao","year":"2023","journal-title":"Nat Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1053\/j.gastro.2022.06.066","article-title":"Radiomics-based machine-learning models can detect pancreatic cancer on prediagnostic computed tomography scans at a substantial lead time before clinical diagnosis","volume":"163","author":"Mukherjee","year":"2022","journal-title":"Gastroenterology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.7150\/thno.52508","article-title":"Fully end-to-end deep-learning-based diagnosis of pancreatic tumors","volume":"11","author":"Si","year":"2021","journal-title":"Theranostics."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5156","DOI":"10.3748\/wjg.v26.i34.5156","article-title":"Construction of a convolutional neural network classifier developed by computed tomography images for pancreatic cancer diagnosis","volume":"26","author":"Ma","year":"2020","journal-title":"World J Gastroenterol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1002\/jmri.28096","article-title":"Application of magnetic resonance imaging in neoadjuvant treatment of pancreatic ductal adenocarcinoma","volume":"55","author":"Qu","year":"2022","journal-title":"J Magn Reson Imaging."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1007\/s00261-023-03801-8","article-title":"Fully automated magnetic resonance imaging-based radiomics analysis for differentiating pancreatic adenosquamous carcinoma from pancreatic ductal adenocarcinoma","volume":"48","author":"Li","year":"2023","journal-title":"Abdom Radiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.diii.2019.07.002","article-title":"Performance of deep learning for differentiating pancreatic diseases on contrast-enhanced magnetic resonance imaging: a preliminary study","volume":"101","author":"Gao","year":"2020","journal-title":"Diagn Interv Imaging."},{"key":"B22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.clinimag.2023.01.008","article-title":"Histogram array and convolutional neural network of DWI for differentiating pancreatic ductal adenocarcinomas from solid pseudopapillary neoplasms and neuroendocrine neoplasms","volume":"96","author":"Shi","year":"2023","journal-title":"Clin Imaging."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e26601","DOI":"10.2196\/26601","article-title":"Hyperpolarized magnetic resonance and artificial intelligence: frontiers of imaging in pancreatic cancer","volume":"9","author":"Enriquez","year":"2021","journal-title":"JMIR Med Inform."},{"key":"B24","doi-asserted-by":"publisher","first-page":"483","DOI":"10.5009\/gnl17348","article-title":"Diagnostic endoscopic ultrasound: technique, current status and future directions","volume":"12","author":"Ang","year":"2018","journal-title":"Gut Liver."},{"key":"B25","doi-asserted-by":"publisher","first-page":"395","DOI":"10.4103\/eus.eus_24_18","article-title":"Discriminating chronic pancreatitis from pancreatic cancer: contrast-enhanced EUS and multidetector computed tomography in direct comparison","volume":"7","author":"Harmsen","year":"2018","journal-title":"Endosc Ultrasound."},{"key":"B26","doi-asserted-by":"publisher","first-page":"E239","DOI":"10.1055\/s-0043-100507","article-title":"When trainees reach competency in performing endoscopic ultrasound: a systematic review","volume":"5","author":"Shahidi","year":"2017","journal-title":"Endosc Int Open."},{"key":"B27","doi-asserted-by":"publisher","first-page":"6743","DOI":"10.1007\/s00432-023-04625-1","article-title":"Artificial intelligence in pancreatic cancer: diagnosis, limitations, and the future prospects\u2014a narrative review","volume":"149","author":"Katta","year":"2023","journal-title":"J Cancer Res Clin Oncol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"106851","DOI":"10.1016\/j.ijsu.2022.106851","article-title":"Preoperative data-based deep learning model for predicting postoperative survival in pancreatic cancer patients","volume":"105","author":"Lee","year":"2022","journal-title":"Int J Surg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.gie.2020.06.021","article-title":"Computer-aided detection-assisted colonoscopy: classification and relevance of false positives","volume":"92","author":"Hassan","year":"2020","journal-title":"Gastrointest Endosc."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1001\/jamadermatol.2019.1735","article-title":"Association between surgical skin markings in dermoscopic images and diagnostic performance of a deep learning convolutional neural network for melanoma recognition","volume":"155","author":"Winkler","year":"2019","journal-title":"JAMA Dermatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nature21056","article-title":"Dermatologist-level classification of skin cancer with deep neural networks","volume":"542","author":"Esteva","year":"2017","journal-title":"Nature."},{"key":"B32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.breast.2019.10.001","article-title":"The ethical, legal and social implications of using artificial intelligence systems in breast cancer care","volume":"49","author":"Carter","year":"2020","journal-title":"Breast Edinb Scotl."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1631671\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T05:25:47Z","timestamp":1754630747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1631671\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":32,"alternative-id":["10.3389\/fmed.2025.1631671"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1631671","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]},"article-number":"1631671"}}