{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:52:12Z","timestamp":1793163132266,"version":"4.5.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare and highly aggressive malignant tumor with a poor prognosis. Although surgery, chemotherapy and other treatment methods have been reported, the current treatment modality has not reached a consensus. This study discusses the diagnosis and treatment of a case of PSCCT with severe respiratory stenosis and endotracheal invasion and reviews the relevant literature. We report the disease of rapidly enlarging mass leading to asphyxiation to raise clinicians\u2019 awareness of this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report a 76-year-old woman presenting with an enlarging right thyroid mass accompanied by severe dyspnea and hoarseness. Computed tomography (CT) scan disclosed a large solid heterogenous nodule with calcification in the right thyroid lobe and prominent adjacent lymph nodes. PSCCT was confirmed by postoperative histopathology and immunohistochemistry. Thyroidectomy with partial tracheectomy and tracheostomy was performed to relieve the patient\u2019s dyspnea. The patient has been discharged after receiving post-operative supportive care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinicians should pay attention to the rapidly enlarging neck mass as it may cause asphyxiation and avoid the loss of treatment opportunities.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1631714","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:17:26Z","timestamp":1753424246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary thyroid squamous cell carcinoma with severe respiratory stenosis and endotracheal invasion: a case report with literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Xueliang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"rju133","DOI":"10.1093\/jscr\/rju133","article-title":"Primary 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