{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:14:37Z","timestamp":1790874877414,"version":"4.1.0"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sarcoidosis is often associated with psychiatric symptoms and syndromes (PSS). This systematic review and meta-analysis aimed to summarize available literature on the prevalence of PSS in sarcoidosis, as well as their potential associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted across PubMed, including case reports and studies that investigated PSS in sarcoidosis. A meta-analysis was performed on studies that assessed the association between sarcoidosis and PSS, using odds ratios (OR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 43 studies and 53 cases on PSS in patients with sarcoidosis. The weighted average prevalence was 24.9% for depression, 28.7% for anxiety, 29.2% for neurocognitive symptoms, 54.4% for fatigue, 50.5% for excessive daytime sleepiness and 26.9% for sleep disturbances and insomnia, with the best available evidence for depression, anxiety and fatigue. The meta-analysis (<jats:italic>n<\/jats:italic> = 962) confirms that patients with sarcoidosis have a significant increased risk of developing PSS when compared with healthy controls (OR = 5.498, CI = 0.430\u201370.238, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). Depressive symptoms and fatigue were most reported on and demonstrated the strongest associations as well (resp. OR = 4.855, z = 2.401, <jats:italic>p<\/jats:italic>=0.016 and OR = 20.231, z = 2.868, <jats:italic>p<\/jats:italic> = 0.004). Significant associations with anxiety and neurocognitive symptoms were also observed, although with less available evidence. Case reports reveal a diagnostic diversity not reflected in study populations, including psychosis and catatonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sarcoidosis is associated with a higher prevalence of PSS. Nonetheless research in this area remains limited. Systematic use of standardized psychiatric assessment tools is recommended.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1634175","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:27:20Z","timestamp":1759123640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychiatric symptoms and syndromes in sarcoidosis: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Andreas","family":"Frans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griet","family":"Van Hoye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Van Meerbeeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Morrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Van Den Eede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/S0140-6736(13)60680-7","article-title":"Sarcoidosis","volume":"383","author":"Valeyre","year":"2014","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/diagnostics11091558","article-title":"Pulmonary sarcoidosis: diagnosis and differential diagnosis","volume":"11","author":"Bernardinello","year":"2021","journal-title":"Diagnostics"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e23100","DOI":"10.1097\/MD.0000000000023100","article-title":"Defining prognosis in sarcoidosis","volume":"99","author":"Lopes","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e1084","DOI":"10.1212\/NXI.0000000000001084","article-title":"Neurosarcoidosis: pathophysiology, diagnosis, and treatment","volume":"8","author":"Bradshaw","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2445191","DOI":"10.1080\/07853890.2024.2445191","article-title":"Neuropsychiatric manifestations of sarcoidosis","volume":"57","author":"Tana","year":"2025","journal-title":"Ann Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref7","author":"Wells","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: 3. 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