{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:29:21Z","timestamp":1790224161747,"version":"4.1.0"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>In recent years, with the continuous development of social productivity and improvements in living standards, the issue of population aging has intensified. As the elderly are susceptible to cardiovascular diseases, osteoporosis, Alzheimer\u2019s disease, and other conditions, the economic and resource burdens associated with treating, caring for, and supporting this demographic rise with their growing numbers, imposing significant pressure on societal development. In light of these challenges, research on natural products possessing anti-aging properties for treating aging-related chronic diseases has gained prominence. Flavonoids, a class of natural bioactive compounds abundantly found in plants, exhibit diverse pharmacological effects, including antioxidant, anti-inflammatory, and anti-osteoporosis activities. Therefore, studying the anti-aging effects of flavonoids is of significant value. This paper reviews recent research on the anti-aging effects of flavonoids by searching databases including CNKI, PubMed, Web of Science, and Google Scholar. The findings are summarized based on research subjects (C. elegans, animal models, and cells), effects, and mechanisms, to provide references for future in-depth research on the anti-aging effects of flavonoids.<\/jats:p>","DOI":"10.3389\/fmed.2025.1637992","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:06:47Z","timestamp":1755616007000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Advancements in research on the anti-aging effects and mechanisms of flavonoids in natural products"],"prefix":"10.3389","volume":"12","author":[{"given":"Wan-yu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-feng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu-huan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms19102937","article-title":"Ageing, cellular senescence and neurodegenerative disease.","volume":"19","author":"Kritsilis","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing.","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature."},{"key":"B3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.5582\/bst.2022.01068","article-title":"Current state of care for the elderly in China in the context of an aging population.","volume":"16","author":"Bao","year":"2022","journal-title":"Biosci Trends."},{"key":"B4","doi-asserted-by":"publisher","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: classification, distribution, biosynthesis, and antioxidant activity.","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2174\/1568026615666141209144506","article-title":"Antioxidant capacities of flavones and benefits in oxidative-stress related diseases.","volume":"15","author":"Catarino","year":"2015","journal-title":"Curr Top Med Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging.","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch Toxicol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules26175377","article-title":"Plant flavonoids: chemical characteristics and biological activity.","volume":"26","author":"Dias","year":"2021","journal-title":"Molecules."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1192131","DOI":"10.3389\/fnut.2023.1192131","article-title":"Flavonoids improve type 2 diabetes mellitus and its complications: a review.","volume":"10","author":"Yi","year":"2023","journal-title":"Front Nutr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1080\/10408398.2022.2124396","article-title":"The structure characteristics, biosynthesis and health benefits of naturally occurring rare flavonoids.","volume":"64","author":"Bo","year":"2022","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/brainsci13091258","article-title":"Neuroprotective potential of flavonoids in brain disorders.","volume":"13","author":"Hasan","year":"2023","journal-title":"Brain Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tem.2020.11.007","article-title":"Flavonoids in bone erosive diseases: perspectives in osteoporosis treatment.","volume":"32","author":"Bellavia","year":"2021","journal-title":"Trends Endocrinol Metab."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/plants12142732","article-title":"Flavonoids: overview of biosynthesis, biological activity, and current extraction techniques.","volume":"12","author":"Liga","year":"2023","journal-title":"Plants."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms23042176","article-title":"Flavonoids-natural gifts to promote health and longevity.","volume":"23","author":"Fan","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/foods13152441","article-title":"Anti-aging effects of flavonoids from plant extracts.","volume":"13","author":"P\u0103cularu-Burada","year":"2024","journal-title":"Foods."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6603","DOI":"10.1073\/pnas.79.21.6603","article-title":"Genetic analysis of life-span in Caenorhabditis elegans.","volume":"79","author":"Johnson","year":"1982","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.plaphy.2020.06.029","article-title":"Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.","volume":"155","author":"Wang","year":"2020","journal-title":"Plant Physiol Biochem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5927","DOI":"10.1021\/jf104798n","article-title":"Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion.","volume":"59","author":"Xue","year":"2011","journal-title":"J Agric Food Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"584900","DOI":"10.3389\/fnut.2020.584900","article-title":"Identification of flavoanoids from finger citron and evaluation on their antioxidative and antiaging activities.","volume":"7","author":"Luo","year":"2020","journal-title":"Front Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"111886","DOI":"10.1016\/j.jep.2019.111886","article-title":"Ultrasonicated sour Jujube seed flavonoids extract exerts ameliorative antioxidant capacity and reduces A\u03b2-induced toxicity in Caenorhabditis elegans.","volume":"239","author":"Yang","year":"2019","journal-title":"J Ethnopharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"8196","DOI":"10.1039\/d1fo01322j","article-title":"Flavonoids from the mung bean coat promote longevity and fitness in Caenorhabditis elegans.","volume":"12","author":"Tao","year":"2021","journal-title":"Food Funct."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5290","DOI":"10.18632\/aging.204627","article-title":"Neuroprotective effect of total flavonoids in stems and leaves of Glycyrrhiza uralensis Fisch. on oxidative stress in HT-22 cells and Caenorhabditis elegans.","volume":"15","author":"Chen","year":"2023","journal-title":"Aging."},{"key":"B22","doi-asserted-by":"publisher","first-page":"12395","DOI":"10.1039\/d1fo02823e","article-title":"Ginkgo seed extract promotes longevity and stress resistance of Caenorhabditis elegans.","volume":"12","author":"Shen","year":"2021","journal-title":"Food Funct."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0199483","DOI":"10.1371\/journal.pone.0199483","article-title":"Epicatechin modulates stress-resistance in C. elegans via insulin\/IGF-1 signaling pathway.","volume":"14","author":"Ayuda-Dur\u00e1n","year":"2019","journal-title":"PLoS One."},{"key":"B24","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.foodres.2011.10.014","article-title":"Influence of catechins and their methylated metabolites on lifespan and resistance to oxidative and thermal stress of Caenorhabditis elegans and epicatechin uptake.","volume":"46","author":"Surco-Laos","year":"2012","journal-title":"Food Res Int."},{"key":"B25","doi-asserted-by":"publisher","first-page":"11020","DOI":"10.1039\/d4fo02479f","article-title":"Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1.","volume":"15","author":"Zhang","year":"2024","journal-title":"Food Funct."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.indcrop.2023.117207","article-title":"A new utilization of total flavonoids from Acer truncatum samara and leaves: anti-aging and metabolic regulation.","volume":"2023","author":"Zhang","year":"2023","journal-title":"Ind Crops Prod."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox11101996","article-title":"Anti-Oxidant and anti-aging effects of phlorizin are mediated by DAF-16-induced stress response and autophagy in Caenorhabditis elegans.","volume":"11","author":"Park","year":"2022","journal-title":"Antioxidants."},{"key":"B28","doi-asserted-by":"publisher","first-page":"187","DOI":"10.7506\/spkx1002-6630-20191206-075","article-title":"Effect of Phloretin on lifespan of Caenorhabditis elegans.","volume":"42","author":"Zhang","year":"2021","journal-title":"Food Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"5000","DOI":"10.18632\/aging.205677","article-title":"Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model.","volume":"16","author":"Rajendran","year":"2024","journal-title":"Aging."},{"key":"B30","doi-asserted-by":"publisher","first-page":"102232","DOI":"10.1016\/j.jchemneu.2023.102232","article-title":"S-adenosylmethionine improves cognitive impairment in D-galactose-induced brain aging by inhibiting oxidative stress and neuroinflammation.","volume":"128","author":"Zhang","year":"2023","journal-title":"J Chem Neuroanat."},{"key":"B31","doi-asserted-by":"publisher","first-page":"105079","DOI":"10.1016\/j.fbio.2024.105079","article-title":"Recombinant protein LPxT-GYLEQ attenuates cognitive impairment by ameliorating oxidative stress in D-galactose-induced aging mice model.","volume":"62","author":"Yang","year":"2024","journal-title":"Food Biosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3969\/J.issn.1671-7856.2023.03.018","article-title":"Research progress of the D-galactose-induced aging mouse model.","volume":"33","author":"Hong","year":"2023","journal-title":"Chin J Comp Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"115361","DOI":"10.1016\/j.jep.2022.115361","article-title":"Anoectochilus roxburghii flavonoids extract ameliorated the memory decline and reduced neuron apoptosis via modulating SIRT1 signaling pathway in senescent mice.","volume":"296","author":"Zeng","year":"2022","journal-title":"J Ethnopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"114997","DOI":"10.1016\/j.jep.2022.114997","article-title":"Saponins and flavonoids from Bacopa floribunda plant extract exhibit antioxidant and anti-inflammatory effects on amyloid beta 1-42-induced Alzheimer\u2019s disease in BALB\/c mice.","volume":"288","author":"Oyeleke","year":"2022","journal-title":"J Ethnopharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"103724","DOI":"10.1016\/j.jff.2019.103724","article-title":"Anti-aging effect of brown black wolfberry on Drosophila melanogaster and D-galactose-induced aging mice.","volume":"65","author":"Zhang","year":"2020","journal-title":"J Funct Foods."},{"key":"B36","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1039\/d0fo01900c","article-title":"Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation.","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"B37","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1039\/d4fo03987d","article-title":"Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice.","volume":"16","author":"Yuan","year":"2025","journal-title":"Food Funct."},{"key":"B38","doi-asserted-by":"publisher","first-page":"104089","DOI":"10.1016\/j.jff.2020.104089","article-title":"Protective effects of Coreopsis tinctoria buds extract against cognitive impairment and brain aging induced by D-galactose.","volume":"73","author":"He","year":"2020","journal-title":"J Funct Foods."},{"key":"B39","doi-asserted-by":"publisher","first-page":"17738","DOI":"10.18632\/aging.103955","article-title":"Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice.","volume":"12","author":"Gao","year":"2020","journal-title":"Aging."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu15081801","article-title":"Nobiletin improves D-galactose-induced aging mice skeletal muscle atrophy by regulating protein homeostasis.","volume":"15","author":"Wang","year":"2023","journal-title":"Nutrients."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.3969\/j.issn.1673-5374.2012.33.001","article-title":"Antioxidant effects of the orientin and vitexin in Trollius chinensis Bunge in D-galactose-aged mice.","volume":"7","author":"An","year":"2012","journal-title":"Neural Regen Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1089\/rej.2015.1708","article-title":"Dietary luteolin reduces proinflammatory microglia in the brain of senescent mice.","volume":"19","author":"Burton","year":"2016","journal-title":"Rejuvenation Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"154270","DOI":"10.1016\/j.phymed.2022.154270","article-title":"Flavonoids from Rhododendron nivale Hook. f delay aging via modulation of gut microbiota and glutathione metabolism.","volume":"104","author":"Guo","year":"2022","journal-title":"Phytomedicine."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.2147\/DDDT.S304885","article-title":"White tip silver needle (slightly fermented white tea) flavonoids help prevent aging via antioxidative and anti-inflammatory effects.","volume":"15","author":"Li","year":"2021","journal-title":"Drug Des Devel Ther."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu14040793","article-title":"Bamboo leaf flavonoids suppress oxidative stress-induced senescence of HaCaT cells and UVB-induced photoaging of mice through p38 MAPK and autophagy signaling.","volume":"14","author":"Gu","year":"2022","journal-title":"Nutrients."},{"key":"B46","doi-asserted-by":"publisher","first-page":"112670","DOI":"10.1016\/j.jep.2020.112670","article-title":"Effect of Anoectochilus roxburghii flavonoids extract on H2O2 - Induced oxidative stress in LO2 cells and D-gal induced aging mice model.","volume":"254","author":"Wang","year":"2020","journal-title":"J Ethnopharmacol."},{"key":"B47","first-page":"5674","article-title":"Effects of icariin on cortical mitochondrial autophagy in mice with D-galactose-induced brain aging model.","volume":"34","author":"Zhou","year":"2019","journal-title":"Chung-hua Chung I Yao Tsa Chih."},{"key":"B48","doi-asserted-by":"publisher","first-page":"365","DOI":"10.13325\/j.cnki.acta.nutr.sin.2024.04.008","article-title":"Improvement of cognitive impairment by myricetin in aging mice.","volume":"46","author":"Zhang","year":"2024","journal-title":"Acta Nutr Sin."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.1016\/j.fct.2012.07.046","article-title":"In vivo antioxidant activity of total flavonoids from indocalamus leaves in aging mice caused by D-galactose.","volume":"50","author":"Jin","year":"2012","journal-title":"Food Chem Toxicol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"57","DOI":"10.13412\/j.cnki.zyyl.2017.01.016","article-title":"Antioxidant effects of hyperoside in aging mice induced by D-galactose.","volume":"33","author":"Gao","year":"2017","journal-title":"Pharmacol Clin Chin Mater Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1089\/jmf.2016.3870","article-title":"Total flavonoid extract from abelmoschus manihot (L.) medic flowers attenuates d-galactose-induced oxidative stress in mouse liver through the Nrf2 pathway.","volume":"20","author":"Qiu","year":"2017","journal-title":"J Med Food."},{"key":"B52","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/fcp.12895","article-title":"Influence of chrysin on D-galactose induced-aging in mice: up regulation of AMP kinase\/liver kinase B1\/peroxisome proliferator-activated receptor-\u03b3 coactivator 1-\u03b1 signaling pathway.","volume":"37","author":"Salama","year":"2023","journal-title":"Fundam Clin Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"121471","DOI":"10.1016\/j.lfs.2023.121471","article-title":"Naringin protects mice from D-galactose-induced lung aging and mitochondrial dysfunction: implication of SIRT1 pathways.","volume":"324","author":"Salama","year":"2023","journal-title":"Life Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"173214","DOI":"10.1016\/j.ejphar.2020.173214","article-title":"Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.","volume":"881","author":"Min","year":"2020","journal-title":"Eur J Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"116110","DOI":"10.1016\/j.biopha.2023.116110","article-title":"Oroxylin A ameliorates ultraviolet radiation-induced premature skin aging by regulating oxidative stress via the Sirt1 pathway.","volume":"171","author":"Liu","year":"2024","journal-title":"Biomed Pharmacother."},{"key":"B56","doi-asserted-by":"publisher","first-page":"12142","DOI":"10.1039\/d1fo01349a","article-title":"Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"key":"B57","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1124\/pharmrev.122.000622","article-title":"Cellular senescence: from mechanisms to current biomarkers and senotherapies.","volume":"75","author":"Lucas","year":"2023","journal-title":"Pharmacol Rev."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.2337\/db21-0536","article-title":"Diabetes-induced cellular senescence and senescence-associated secretory phenotype impair cardiac regeneration and function independently of age.","volume":"71","author":"Marino","year":"2022","journal-title":"Diabetes."},{"key":"B59","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype.","volume":"9","author":"Kumari","year":"2021","journal-title":"Front Cell Dev Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1038\/s42255-021-00491-8","article-title":"The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice.","volume":"3","author":"Xu","year":"2021","journal-title":"Nat Metab."},{"key":"B61","doi-asserted-by":"publisher","first-page":"23286","DOI":"10.1021\/acs.jafc.4c05945","article-title":"Enhanced SIRT1 activity by galangin mitigates UVB-induced senescence in dermal fibroblasts via p53 acetylation regulation and activation.","volume":"72","author":"Wen","year":"2024","journal-title":"J Agric Food Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"27737","DOI":"10.1021\/acs.jafc.4c04887","article-title":"Myricetin alleviates silica-mediated lung fibrosis via PPAR\u03b3-PGC-1\u03b1 loop and suppressing mitochondrial senescence in epithelial cells.","volume":"72","author":"Xie","year":"2024","journal-title":"J Agric Food Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e12431","DOI":"10.1111\/cpr.12431","article-title":"Oroxylin A inhibits ethanol-induced hepatocyte senescence via YAP pathway.","volume":"51","author":"Jin","year":"2018","journal-title":"Cell Prolif."},{"key":"B64","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2174\/0113862073273675231114112804","article-title":"Network pharmacology and experimental validation to elucidate the pharmacological mechanisms of luteolin against chondrocyte senescence.","volume":"28","author":"Long","year":"2025","journal-title":"Comb Chem High Throughput Screen."},{"key":"B65","doi-asserted-by":"publisher","first-page":"102649","DOI":"10.1016\/j.redox.2023.102649","article-title":"Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERR\u03b1-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats.","volume":"61","author":"Li","year":"2023","journal-title":"Redox Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox11081450","article-title":"Preventive effect of cocoa flavonoids via suppression of oxidative stress-induced apoptosis in auditory senescent cells.","volume":"11","author":"Del Mar Rivas-Chac\u00f3n","year":"2022","journal-title":"Antioxidants."},{"key":"B67","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3109\/13880209.2012.738332","article-title":"Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K\/AKT-eNOS signaling pathway.","volume":"51","author":"Xiao-Hong","year":"2013","journal-title":"Pharm Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1142\/S0192415X21500592","article-title":"Apigenin alleviates oxidative stress-induced cellular senescence via modulation of the SIRT1-NAD[Formula: see text]-CD38 axis.","volume":"49","author":"Li","year":"2021","journal-title":"Am J Chin Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3969\/j.issn.1671-7856.2023.05.008","article-title":"Baicalein protects mouse nucleus pulposus cells from TBHP-induced senescence.","volume":"33","author":"Can","year":"2023","journal-title":"Chin J Comp Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-024-01005-w","article-title":"Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice.","volume":"31","author":"Shen","year":"2024","journal-title":"J Biomed Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.16333\/j.1001-6880.2021.10.017","article-title":"Study on the anti-aging mechanism of Erigeron breviscapus based on network pharmacology and molecular docking.","volume":"33","author":"Pu","year":"2021","journal-title":"Nat Prod Res Dev."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3252","DOI":"10.3969\/j.issn.1005-9202.2015.12.029","article-title":"Ultrasonic extraction and anti-aging effect of total flavonoids from white fruit (Hibiscus esculentus).","volume":"35","author":"Li","year":"2015","journal-title":"Chin J Gerontol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells11040599","article-title":"Flavonoids from sacred lotus stamen extract slows chronological aging in yeast model by reducing oxidative stress and maintaining cellular metabolism.","volume":"11","author":"Tungmunnithum","year":"2022","journal-title":"Cells."},{"key":"B74","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.3390\/molecules24224093","article-title":"The anti-aging potential of neohesperidin and its synergistic effects with other citrus flavonoids in extending chronological lifespan of saccharomyces cerevisiae BY4742.","volume":"24","author":"Guo","year":"2019","journal-title":"Molecules."},{"key":"B75","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/13813455.2019.1702059","article-title":"Adaptation to oxidative stress at cellular and tissue level.","volume":"128","author":"Akki","year":"2019","journal-title":"Arch Physiol Biochem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry.","volume":"11","author":"Harman","year":"2002","journal-title":"J Gerontol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1532-5415.1977.tb00674.x","article-title":"Free radical theory of aging: effect of free-radical-reaction inhibitors on the immune response.","volume":"25","author":"Harman","year":"1977","journal-title":"J Am Geriatr Soc."},{"key":"B78","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/j.1749-6632.1994.tb12069.x","article-title":"Free-radical theory of aging. Increasing the functional life span.","volume":"717","author":"Harman","year":"1994","journal-title":"Ann N Y Acad Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3724\/SP.J.1206.2014.00019","article-title":"The nutrients-regulated insulin\/IGF-1 and TOR pathways play an important role in C. elegans aging.","volume":"41","author":"Chen","year":"2014","journal-title":"Prog Biochem Biophys."},{"key":"B80","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1093\/gerona\/61.5.444","article-title":"daf-16 protects the nematode Caenorhabditis elegans during food deprivation.","volume":"61","author":"Henderson","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/88850","article-title":"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin\/IGF-1 and germline signaling.","volume":"28","author":"Lin","year":"2001","journal-title":"Nat Genet."},{"key":"B82","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/0012-1606(88)90138-8","article-title":"Mutants of Caenorhabditis elegans that form dauer-like larvae.","volume":"126","author":"Albert","year":"1988","journal-title":"Dev Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jgg.2021.11.005","article-title":"Mitochondrial sirtuins, metabolism, and aging.","volume":"49","author":"Ji","year":"2022","journal-title":"J Genet Genomics."},{"key":"B84","doi-asserted-by":"publisher","first-page":"87","DOI":"10.14348\/molcells.2016.2318","article-title":"Sirt1 and the mitochondria.","volume":"39","author":"Tang","year":"2016","journal-title":"Mol Cells."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI152868","article-title":"A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice.","volume":"132","author":"Guo","year":"2022","journal-title":"J Clin Invest."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom12070921","article-title":"Monoterpenes as Sirtuin-1 activators: therapeutic potential in aging and related diseases.","volume":"12","author":"Sousa","year":"2022","journal-title":"Biomolecules."},{"key":"B87","doi-asserted-by":"publisher","first-page":"111215","DOI":"10.1016\/j.mad.2020.111215","article-title":"SIRT1 and aging related signaling pathways.","volume":"187","author":"Chen","year":"2020","journal-title":"Mech Ageing Dev."},{"key":"B88","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe.","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell."},{"key":"B89","doi-asserted-by":"publisher","first-page":"15747","DOI":"10.3390\/ijms232415747","article-title":"Chrysin induces apoptosis via the MAPK pathway and regulates ERK\/mTOR-mediated autophagy in MC-3 cells.","volume":"23","author":"Jung","year":"2022","journal-title":"Int J Mol Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2105152","DOI":"10.1002\/adfm.202105152","article-title":"Treating LRRK2-related Parkinson\u2019s disease by inhibiting the mTOR signaling pathway to restore autophagy.","volume":"31","author":"Cui","year":"2021","journal-title":"Adv Funct Mater."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41232-022-00197-8","article-title":"The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?","volume":"42","author":"Ohtani","year":"2022","journal-title":"Inflamm Regen."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1637992\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:06:58Z","timestamp":1755616018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1637992\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":91,"alternative-id":["10.3389\/fmed.2025.1637992"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1637992","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"article-number":"1637992"}}