{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:12:58Z","timestamp":1790370778785,"version":"4.1.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sir\u0101granthi results from vitiated v\u0101ta in sir\u0101s, leading to granthi due to V\u0101taprakopaka nid\u0101nas. \u0100c\u0101rya Vagbhata recommends sir\u0101vyadha for treating sir\u0101granthi. The role of inflammation in vascular diseases is explored, with a focus on Interleukin-6 as a key biomarker. The absence of studies on sir\u0101vyadha\u2019s impact on inflammatory biomarkers, particularly Interleukin-6, underscores the study\u2019s relevance, aiming to observe changes in inflammatory response in varicose veins post-sir\u0101vyadha within a 15-day period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To observe changes in IL-6 values before and after sir\u0101vyadha within a 15-day period in individuals with varicose veins. Materials and Methods: After excluding deep vein thrombosis (DVT) through lower limb color doppler, five subjects who satisfied the inclusion criteria were selected. Assessments included BT, CT, Hb screening, and parameters like AVVQ, pain, edema, tortuosity, skin pigmentation, and itching. Sir\u0101vyadha was performed over the tortuous vein with an 18G needle, and sample was collected from drained blood for IL-6 testing. After a 15-day follow-up, Sir\u0101vyadha was repeated, and assessment of all parameters were done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistically significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;0.05) were observed after treatment in Interleukin-6, AVVQ, pain, edema, tortuosity, and skin pigmentation. However, itching showed no statistically significant difference after treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In all 5 cases, a reduction in the rate of IL-6 was observed. Remarkably, three patients with initially high values showed a statistically significant reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05) after sir\u0101vyadha treatment, indicating a reduction in inflammation. Clinical and statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05) were also observed in subjective parameters such as pain, edema, tortuosity, and skin pigmentation. Although itching decreased in patients, it did not reach statistical significance, possibly due to some patients not experiencing itching before the procedure. The study demonstrates that sir\u0101vyadha effectively reduces the inflammatory response and subjective symptoms of varicose veins. Furthermore, the improvement in the quality of life after sir\u0101vyadha was highly significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Overall, the study supports sir\u0101vyadha\u2019s efficacy in reducing inflammatory biomarker IL-6 and subjective symptoms in varicose veins.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1638127","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:25:58Z","timestamp":1764570358000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimation of the inflammatory biomarker IL-6 in blood samples from varicose veins after repeated sir\u0101vyadha (venesection\/bloodletting)"],"prefix":"10.3389","volume":"12","author":[{"given":"Anjana","family":"Sivadas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiswarya","family":"Indira Vikraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnuraj","family":"Santharajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadambari","family":"Panthalloor Balakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Unnikrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameswaran","family":"Kesavan Namboothiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref1","article-title":"Sushruta Samhita","volume-title":"Acharya with Nibandha Sangraha Commentary of Sri 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granthi","volume":"2","author":"Shetty","year":"2017","journal-title":"J Ayurveda Integr Med Sci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/WON.0b013e318202c47a","article-title":"Itch: association with chronic venous disease, pain, and quality of life","volume":"38","author":"Paul","year":"2011","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.21760\/jaims.4.4.2","article-title":"A comparative clinical study of classical and non-classical Sir\u0100vyadha in Vipadika","volume":"4","author":"Gaonkar","year":"2019","journal-title":"J Ayurveda Integr Med Sci"}],"container-title":["Frontiers in 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