{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:53:19Z","timestamp":1791255199259,"version":"4.1.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Since <jats:italic>Kerstersia gyiorum<\/jats:italic> was first described and named in 2003, reports of human infections caused by this organism have gradually increased. Here, we present a detailed report of a severe case of lower right limb infection caused by <jats:italic>K. gyiorum<\/jats:italic> that was characterized by rapid disease progression and multidrug resistance. We also present the complete genome sequence of the isolate, WCHKG1. A systematic analysis of the clinical features of our case patient and previous <jats:italic>K. gyiorum<\/jats:italic>-infected patients revealed that the most common site of infection was the lungs (48%), and that the organism showed the lowest sensitivity to commonly used quinolones among the major antibiotic classes. Clinical infections caused by <jats:italic>K. gyiorum<\/jats:italic> may be underestimated, thus the use of quinolones in treating such infections should be avoided. Genomic and phylogenetic analyses of <jats:italic>K. gyiorum<\/jats:italic> identified conservation of antibiotic efflux pump systems and virulence factors, which may play critical roles in its antibiotic resistance and pathogenicity. Furthermore, evidence of clonal transmission in animals suggests a need for vigilance regarding potential clonal spread in clinical settings. Our study contributes to the current understanding of <jats:italic>K. gyiorum<\/jats:italic> and offers useful insights to support its clinical management and infection control.<\/jats:p>","DOI":"10.3389\/fmed.2025.1639069","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T13:22:31Z","timestamp":1757683351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe lower limb infection by Kerstersia gyiorum: clinical and genomic insights into an underestimated pathogen"],"prefix":"10.3389","volume":"12","author":[{"given":"Jiayuan","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangmin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1099\/ijs.0.02609-0","article-title":"Kerstersia gyiorum gen. 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