{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:40:43Z","timestamp":1759725643485,"version":"build-2065373602"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Extra-pulmonary emphysema is characterized by the presence of gas within loose soft tissues outside the lungs. This condition is frequently mistaken for acute cardiovascular diseases, leading to potential misdiagnosis. Enhancing clinical recognition of extra-pulmonary emphysema is critical for improving patient outcomes at high altitude. Notably, hyperbaric oxygen therapy has shown promise as a treatment modality for this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Object<\/jats:title><jats:p>To evaluate the feasibility of early detection and hyperbaric oxygen therapy for extra-pulmonary emphysema in high-altitude regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis was conducted on non-trauma patients presenting with chest and back pain in areas exceeding 5,000 meters in altitude from May to December 2024. Patients with a confirmed diagnosis of extra-pulmonary emphysema based on computed tomography (CT) imaging were included. Clinical data and treatment details were collected, and prognostic outcomes were monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine young male patients, averaging 23.56\u202f\u00b1\u202f5.27\u202fyears, presented with symptoms of neck and chest pain. None had a history of chronic disease, surgery, or trauma. Initial misdiagnosis occurred in seven cases, with only two correctly identified as simple extra-pulmonary emphysema. Eight patients showed significantly improvement following hyperbaric oxygen therapy at 2.0 atmospheres absolute (ATA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recognizing extra-pulmonary emphysema at high altitude is crucial, especially severe mediastinal emphysema. Hyperbaric oxygen therapy may serve as an effective treatment option for this condition.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1640035","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:10:53Z","timestamp":1759723853000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe chest and back pain due to extra-pulmonary emphysema above 5,000 m: a series of case 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emphysema, pneumomediastinum, pneumoretroperitoneum, and pneumoscrotum: unusual complications of acute perforated diverticulitis","volume":"2014","author":"Fosi","year":"2014","journal-title":"Case Rep Radiol"},{"key":"ref2","volume-title":"Subcutaneous emphysema","author":"Kukuruza","year":"2025"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5582\/irdr.2024.01020","article-title":"Spontaneous pneumomediastinum: a comprehensive review of diagnosis and management","volume":"13","author":"Talwar","year":"2024","journal-title":"Intractable Rare Dis Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1053\/j.jvca.2023.12.025","article-title":"Macklin effect: from pathophysiology to clinical implication","volume":"38","author":"Angelini","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.3390\/ijerph18041692","article-title":"Pulmonary hypertension in acute and chronic high altitude maladaptation disorders","volume":"18","author":"Sydykov","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"ref6","first-page":"159","volume-title":"Subcutaneous emphysema, a different way to diagnoseRev Assoc Med Bras","author":"Medeiros","year":"1992"},{"key":"ref7","article-title":"Pneumomediastinum","volume-title":"StatPearls [Internet]","author":"Iteen","year":"2025"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1002\/aorn.12097","article-title":"Hyperbaric oxygen therapy: indications, contraindications, and use at a tertiary care center: 1.3 www.Aornjournal.Org\/content\/cme","volume":"107","author":"Howell","year":"2018","journal-title":"AORN J"},{"key":"ref9","first-page":"475","article-title":"Benign subcutaneous emphysema treated with hyperbaric oxygen therapy after surgical exploration","volume-title":"Med J Armed Forces India","author":"Al-Njadat","year":"2022"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF03018855","article-title":"Differential lung ventilation and emergency hyperbaric oxygenation for repair of a tracheal tear","volume":"47","author":"Ratzenhofer-Komenda","year":"2000","journal-title":"Canad J Anesthesia"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"14612","DOI":"10.3390\/ijms241914612","article-title":"Identifying the target traumatic brain injury population for hyperbaric oxygen therapy","volume":"24","author":"Schimmel","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.biopha.2018.10.142","article-title":"Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections","volume":"109","author":"Memar","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.28920\/dhm51.1.119-123","article-title":"Pneumomediastinum and the use of hyperbaric oxygen treatment","volume":"51","author":"Price","year":"2021","journal-title":"Diving Hyperb Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s12262-013-0975-4","article-title":"Classification and Management of Subcutaneous Emphysema: a 10-year experience","volume":"77","author":"Aghajanzadeh","year":"2015","journal-title":"Indian J Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"E371","DOI":"10.1097\/BRS.0b013e3181995c87","article-title":"Bilateral pneumothoraces, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and subcutaneous emphysema after thoracoscopic anterior fracture stabilization. [case reports; journal article]","volume":"34","author":"Garcia","year":"2009","journal-title":"Spine"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"488","DOI":"10.4097\/kjae.2012.62.5.488","article-title":"Bilateral pneumothoraces, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and subcutaneous emphysema after percutaneous tracheostomy - a case report","volume":"62","author":"Kim","year":"2012","journal-title":"Korean J Anesthesiol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/j.jpedsurg.2008.12.025","article-title":"Subcutaneous emphysema, pneumomediastinum, pneumothorax, pneumoperitoneum, and pneumoretroperitoneum by insufflation of compressed air at the external genitalia in a child","volume":"44","author":"Muramori","year":"2009","journal-title":"J Pediatr Surg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e1591029446","DOI":"10.2174\/0115734056234694230922101747","article-title":"High altitude pulmonary edema combined with spontaneous pneumomediastinum: a case report","volume":"20","author":"Li","year":"2024","journal-title":"Curr Med Imaging Rev"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1392696","DOI":"10.3389\/fpubh.2024.1392696","article-title":"Short-term changes in chest CT images among individuals at low altitude after entering high altitude environments","volume":"12","author":"Wang","year":"2024","journal-title":"Front Public Health"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.tim.2019.05.003","article-title":"Antimicrobial tolerance and metabolic adaptations in microbial biofilms","volume":"27","author":"Crabb\u00e9","year":"2019","journal-title":"Trends Microbiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"100008","DOI":"10.1016\/j.bioflm.2019.100008","article-title":"Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: not just hot air","volume":"1","author":"Jensen","year":"2019","journal-title":"Biofilm"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.3390\/ijms18122688","article-title":"The consequences of being in an infectious biofilm: microenvironmental conditions governing antibiotic tolerance","volume":"18","author":"S\u00f8nderholm","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.rmr.2021.12.004","article-title":"Spontaneous pneumomediastinum","volume":"39","author":"Halitim","year":"2022","journal-title":"Rev Mal Respir"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"e18326","DOI":"10.1016\/j.heliyon.2023.e18326","article-title":"Spontaneous pneumomediastinum with subcutaneous emphysema in a young healthy female, a case report","volume":"9","author":"Molla","year":"2023","journal-title":"Heliyon"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"730","DOI":"10.12669\/pjms.38.3.5529","article-title":"Spontaneous pneumomediastinum, pneumothorax and subcutaneous emphysema in critically ill COVID-19 patients: a systematic review","volume":"38","author":"Shahsavarinia","year":"2022","journal-title":"Pak J Med Sci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"10574","DOI":"10.1117\/12.2293455","article-title":"Deep learning for biomarker regression: application to osteoporosis and emphysema on chest CT scans","author":"Gonzalez","year":"2018","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12890-022-01848-9","article-title":"Association between plasma sRAGE and emphysema according to the genotypes of AGER gene","volume":"22","author":"Sin","year":"2022","journal-title":"BMC Pulm Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1164\/rccm.202301-0067OC","article-title":"Blood-based transcriptomic and proteomic biomarkers of emphysema","volume":"209","author":"Suryadevara","year":"2024","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1640035\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T04:10:54Z","timestamp":1759723854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1640035\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":28,"alternative-id":["10.3389\/fmed.2025.1640035"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1640035","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"article-number":"1640035"}}