{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:40:58Z","timestamp":1783122058692,"version":"3.54.6"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to characterize the labor duration distribution and evaluate maternal-neonatal outcomes of vaginal birth after cesarean (VBAC) under epidural anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In this retrospective comparative study, we analyzed 156 term singleton VBAC cases with epidural anesthesia at Chengdu Women\u2019s and Children\u2019s Central Hospital (January 2021\u2013December 2024), matched 1:1 by age to nulliparous controls. Comparative analyses of baseline characteristics, pregnancy complications, delivery modes, pregnancy outcomes, and labor durations were performed using independent\n                      <jats:italic>t<\/jats:italic>\n                      -tests, Mann\u2013Whitney U tests, and\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \/Fisher\u2019s exact tests. VBAC cases were stratified by prior labor attempt (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f25 with vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f131 without) to assess its impact on labor progression, with Spearman tests evaluating inter-stage correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demonstrated that VBAC cases had significantly higher median 24\u202fh postpartum blood loss (330 vs. 250\u202fmL), postpartum hemorrhage rates (43% vs. 20%), and neonatal NICU admission rates (10% vs. 2%) compared to nulliparous controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). The 95th percentile durations for VBAC were 730\u202fmin (first stage) and 81\u202fmin (second stage), both significantly shorter than controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05), while third-stage durations were comparable (95th percentile, 11 vs. 10\u202fmin,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). Prior labor attempt did not influence VBAC labor progression (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). Positive correlations existed between first and second stages in both groups (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.297,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that VBAC under epidural anesthesia may progress faster through first and second stages of labor than nulliparous deliveries but carries higher risks of adverse outcomes. Clinical management should integrate multifactorial assessment, warranting further investigation into labor patterns and outcome relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1643142","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:42:24Z","timestamp":1762429344000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Duration of labor stages and pregnancy outcomes in vaginal birth after cesarean: a retrospective comparative analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Tianying","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"191.e1","DOI":"10.1016\/j.ajog.2018.10.028","article-title":"The impact of extending the second stage of labor to prevent primary cesarean delivery on maternal and neonatal outcomes","volume":"220","author":"Zipori","year":"2019","journal-title":"Am J Obstet 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