{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:37:56Z","timestamp":1787585876752,"version":"build-2736575974"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ulcerative colitis (UC) is intricately associated with the dysfunction of the intestinal barrier, making the restoration of barrier integrity a promising therapeutic target. Nonetheless, there is a notable deficiency in comprehensive and systematic investigations in this domain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,554 articles were extracted from the Web of Science Core Collection (WoSCC) and Scopus. We employed analytical tools such as CiteSpace and VOSviewer to identify leading topics and create visual representations of countries\/regions, institutions, authors, keyword networks, and journals pertinent to this field of study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Since 2020, there has been a marked increase in the annual publication rate, with China accounting for 72.13% of the total output. In terms of international collaboration patterns, China and the United States form the core cooperative system, which has served as the foundation for establishing a globalized research collaboration network. Frequently occurring keywords underscore the application of traditional Chinese medicine, repair of tight junctions, and the NF-\u03baB\/oxidative stress pathway. Contemporary studies are increasingly emphasizing targeted delivery and clinical translation, with epithelial barriers and organoid models emerging as prominent research foci. Influential publications have primarily concentrated on the pathological mechanisms and experimental models related to UC, while the journal \u201cInflammatory Bowel Diseases\u201d has proven to be an essential platform for the dissemination of knowledge within this sphere.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The intestinal barrier has surfaced as a significant therapeutic target for UC, fostering a multidisciplinary research network. Future endeavors should aim at enhancing the linkage between mechanistic studies and clinical implementations to yield improved practical outcomes. Additionally, promoting a more equitable distribution of international collaborations is vital for the advancement of targeted intervention strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1657620","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:28:23Z","timestamp":1759987703000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Research trends of intestinal barrier in ulcerative colitis: a bibliometric analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Qi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/jbcpp-2018-0036","article-title":"Immune response and inflammatory pathway of ulcerative colitis","volume":"30","author":"Tatiya-aphiradee","year":"2018","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1093\/ecco-jcc\/jjad064","article-title":"Transepithelial barrier dysfunction drives microbiota dysbiosis to initiate epithelial clock-driven inflammation","volume":"17","author":"Pai","year":"2023","journal-title":"J Crohns Colitis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of disease: inflammatory bowel diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1172\/JCI123374","article-title":"Fbxw7 increases CCL2\/7 in CX3CR1hi macrophages to promote intestinal inflammation","volume":"129","author":"He","year":"2019","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.apsb.2021.04.007","article-title":"Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3681","DOI":"10.1007\/s00210-024-03485-x","article-title":"5-aminosalicylic acid alleviates colitis and protects intestinal barrier function by modulating gut microbiota in mice","volume":"398","author":"Wang","year":"2025","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"112661","DOI":"10.1016\/j.intimp.2024.112661","article-title":"Eudragit S100 coated iron oxide-chitosan nanocomposites for colon targeting of 5-aminosalicylic acid ameliorate ulcerative colitis by improving intestinal barrier function and inhibiting NLRP3 inflammasome","volume":"139","author":"Zhang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e0223994","DOI":"10.1371\/journal.pone.0223994","article-title":"Visualizing a field of research: a methodology of systematic scientometric reviews","volume":"14","author":"Chen","year":"2019","journal-title":"PLoS One"},{"key":"ref10","first-page":"724","article-title":"CiteSpace II: visualization and knowledge discovery in bibliographic databases","volume":"2005","author":"Synnestvedt","year":"2005","journal-title":"AMIA Annu Symp Proc"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Informetr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e310502","DOI":"10.3145\/epi.2022.sep.02","article-title":"Scimago graphica: a new tool for exploring and visually communicating data","author":"Hassan-Montero","year":"2022","journal-title":"Prof Inferm"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"e270","DOI":"10.1002\/imt2.270","article-title":"Gut\u2013X axis","volume":"4","author":"Lin","year":"2025","journal-title":"iMeta"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.3748\/wjg.v27.i46.7925","article-title":"COVID-19 and gut immunomodulation","volume":"27","author":"Roy","year":"2021","journal-title":"World J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"5640","DOI":"10.1002\/jmv.28067","article-title":"COVID-19 and inflammatory bowel disease crosstalk: from emerging association to clinical proposal","volume":"94","author":"Tao","year":"2022","journal-title":"J Med Virol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"733992","DOI":"10.3389\/fcimb.2022.733992","article-title":"The gut microbiota in inflammatory bowel disease","volume":"12","author":"Qiu","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-024-07571-1","article-title":"Single-cell integration reveals metaplasia in inflammatory gut diseases","volume":"635","author":"Oliver","year":"2024","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"5596","DOI":"10.7150\/thno.73650","article-title":"Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis","volume":"12","author":"Gao","year":"2022","journal-title":"Theranostics"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e2301826","DOI":"10.1002\/adhm.202301826","article-title":"Novel natural carrier-free self-assembled nanoparticles for treatment of ulcerative colitis by balancing immune microenvironment and intestinal barrier","volume":"12","author":"Gao","year":"2023","journal-title":"Adv Healthc Mater"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.34133\/research.0188","article-title":"Mulberry biomass-derived nanomedicines mitigate colitis through improved inflamed mucosa accumulation and intestinal microenvironment modulation","volume":"6","author":"Yang","year":"2023","journal-title":"Research"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/d41586-018-00927-4","article-title":"China declared world\u2019s largest producer of scientific articles","volume":"553","author":"Tollefson","year":"2018","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1086\/715021","article-title":"Systematic bias in the progress of research","volume":"129","author":"Rubin","year":"2021","journal-title":"J Polit Econ"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"871713","DOI":"10.3389\/fimmu.2022.871713","article-title":"The role of intestinal mucosal barrier in autoimmune disease: a potential target","volume":"13","author":"An","year":"2022","journal-title":"Front Immunol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrgastro.2016.169","article-title":"The intestinal epithelial barrier: a therapeutic target?","volume":"14","author":"Odenwald","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"848344","DOI":"10.3389\/fmed.2022.848344","article-title":"The role and function of mucins and its relationship to inflammatory bowel disease","volume":"9","author":"Kang","year":"2022","journal-title":"Front Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1111\/febs.15504","article-title":"Home, sweet home: how mucus accommodates our microbiota","volume":"288","author":"Wang","year":"2021","journal-title":"FEBS J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"100655","DOI":"10.1016\/j.bbrep.2019.100655","article-title":"Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients","volume":"19","author":"Wibowo","year":"2019","journal-title":"Biochem Biophys Rep"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s12276-021-00617-8","article-title":"Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis","volume":"53","author":"Fang","year":"2021","journal-title":"Exp Mol Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","article-title":"Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis","volume":"63","author":"Johansson","year":"2014","journal-title":"Gut"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1136\/gutjnl-2018-317571","article-title":"Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis","volume":"68","author":"van der Post","year":"2019","journal-title":"Gut"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.it.2018.04.002","article-title":"The intestinal epithelium: central coordinator of mucosal immunity","volume":"39","author":"Allaire","year":"2018","journal-title":"Trends Immunol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e338","DOI":"10.1038\/emm.2017.20","article-title":"Roles of intestinal epithelial cells in the maintenance of gut homeostasis","volume":"49","author":"Okumura","year":"2017","journal-title":"Exp Mol Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"The leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/s41385-022-00550-7","article-title":"Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis","volume":"15","author":"Grubi\u0161i\u0107","year":"2022","journal-title":"Mucosal Immunol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/s11845-020-02490-2","article-title":"Review of claudin proteins as potential biomarkers for necrotizing enterocolitis","volume":"190","author":"Griffiths","year":"2021","journal-title":"Ir J Med Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41575-023-00766-3","article-title":"Paracellular permeability and tight junction regulation in gut health and disease","volume":"20","author":"Horowitz","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"183344","DOI":"10.1016\/j.bbamem.2020.183344","article-title":"Channel functions of claudins in the organization of biological systems","volume":"1862","author":"Meoli","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"8562","DOI":"10.3390\/ijms24108562","article-title":"Claudin barriers on the brink: how conflicting tissue and cellular priorities drive IBD pathogenesis","volume":"24","author":"Capaldo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1053\/j.gastro.2021.08.047","article-title":"The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair","volume":"161","author":"Kuo","year":"2021","journal-title":"Gastroenterology"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"972","DOI":"10.3390\/ijms21030972","article-title":"The integral role of tight junction proteins in the repair of injured intestinal epithelium","volume":"21","author":"Slifer","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-immunol-070119-115104","article-title":"Interaction between the microbiota, epithelia, and immune cells in the intestine","volume":"38","author":"Kayama","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1273407","DOI":"10.3389\/fphar.2023.1273407","article-title":"Repairing the intestinal mucosal barrier of traditional chinese medicine for ulcerative colitis: a review","volume":"14","author":"Zong","year":"2023","journal-title":"Front Pharmacol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1053\/j.gastro.2016.07.008","article-title":"Inflammation and the intestinal barrier: leukocyte\u2013epithelial cell interactions, cell junction remodeling, and mucosal repair","volume":"151","author":"Luissint","year":"2016","journal-title":"Gastroenterology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"113544","DOI":"10.1016\/j.intimp.2024.113544","article-title":"Novel targets for mucosal healing in inflammatory bowel disease therapy","volume":"144","author":"Mansouri","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3390\/biomedicines10020289","article-title":"Implication of intestinal barrier dysfunction in gut dysbiosis and diseases","volume":"10","author":"Stolfi","year":"2022","journal-title":"Biomedicine"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1136\/gutjnl-2023-329964","article-title":"Different levels of healing in inflammatory bowel diseases: mucosal, histological, transmural, barrier and complete healing","volume":"72","author":"Neurath","year":"2023","journal-title":"Gut"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1053\/j.gastro.2022.10.014","article-title":"Intestinal barrier healing is superior to endoscopic and histologic remission for predicting major adverse outcomes in inflammatory bowel disease: the prospective ERIca trial","volume":"164","author":"Rath","year":"2023","journal-title":"Gastroenterology"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"116879","DOI":"10.1016\/j.jep.2023.116879","article-title":"Traditional chinese medicine: a promising strategy to regulate the imbalance of bacterial flora, impaired intestinal barrier and immune function attributed to ulcerative colitis through intestinal microecology","volume":"318","author":"Wang","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"112105","DOI":"10.1016\/j.jep.2019.112105","article-title":"A review of pharmacological and clinical studies on the application of shenling baizhu san in treatment of ulcerative colitis","volume":"244","author":"Ma","year":"2019","journal-title":"J Ethnopharmacol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13020-022-00696-3","article-title":"Effects of shenling baizhu powder on pyrotinib-induced diarrhea: analysis of gut microbiota, metabonomics, and network pharmacology","volume":"17","author":"Lai","year":"2022","journal-title":"Chin Med"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"155873","DOI":"10.1016\/j.phymed.2024.155873","article-title":"Paeoniae decoction restores intestinal barrier dysfunction by promoting the interaction between ILC3 and gut flora","volume":"132","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"524287","DOI":"10.3389\/fphar.2021.524287","article-title":"Shaoyao decoction inhibits inflammation and improves intestinal barrier function in mice with dextran sulfate sodium-induced colitis","volume":"12","author":"Chi","year":"2021","journal-title":"Front Pharmacol"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"9839474","DOI":"10.1155\/2019\/9839474","article-title":"Gut microbiota-mediated NLRP12 expression drives the attenuation of dextran sulphate sodium-induced ulcerative colitis by qingchang wenzhong decoction","volume":"2019","author":"Sun","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s11655-021-3343-4","article-title":"Huangqin decoction attenuates DSS-induced mucosal damage and promotes epithelial repair via inhibiting TNF-\u03b1-induced NF-\u03baB activation","volume":"28","author":"Gu","year":"2022","journal-title":"Chin J Integr Med"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"154052","DOI":"10.1016\/j.phymed.2022.154052","article-title":"Huangqin decoction ameliorates DSS-induced ulcerative colitis: role of gut microbiota and amino acid metabolism, mTOR pathway and intestinal epithelial barrier","volume":"100","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"154660","DOI":"10.1016\/j.phymed.2023.154660","article-title":"Modified gegen qinlian decoction ameliorates DSS-induced chronic colitis in mice by restoring the intestinal mucus barrier and inhibiting the activation of \u03b3\u03b4T17 cells","volume":"111","author":"Ma","year":"2023","journal-title":"Phytomedicine"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"153182","DOI":"10.1016\/j.phymed.2020.153182","article-title":"Gegen qinlian decoction maintains colonic mucosal homeostasis in acute\/chronic ulcerative colitis via bidirectionally modulating dysregulated notch signaling","volume":"68","author":"Zhao","year":"2020","journal-title":"Phytomedicine"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"115919","DOI":"10.1016\/j.jep.2022.115919","article-title":"Gegen qinlian decoction activates AhR\/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice","volume":"302","author":"Wang","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"115741","DOI":"10.1016\/j.jep.2022.115741","article-title":"Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity","volume":"300","author":"Niu","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"109883","DOI":"10.1016\/j.biopha.2020.109883","article-title":"Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2\/MyD88\/NF-kB pathway and regulation of microbiota","volume":"124","author":"Wu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"114108","DOI":"10.1016\/j.jep.2021.114108","article-title":"Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier","volume":"279","author":"Shi","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1089\/jmf.2020.0129","article-title":"Effects of the use of curcumin on ulcerative colitis and crohn\u2019s disease: a systematic review","volume":"24","author":"Goulart","year":"2021","journal-title":"J Med Food"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.3390\/nu14245249","article-title":"Old but fancy: curcumin in ulcerative colitis-current overview","volume":"14","author":"Pituch-Zdanowska","year":"2022","journal-title":"Nutrients"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3967935","DOI":"10.1155\/2022\/3967935","article-title":"Quality of evidence supporting the role of supplement curcumin for the treatment of ulcerative colitis: an overview of systematic reviews","volume":"2022","author":"Shi","year":"2022","journal-title":"Gastroenterol Res Pract"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jare.2021.11.017","article-title":"Targeted delivery of chinese herb pair-based berberine\/tannin acid self-assemblies for the treatment of ulcerative colitis","volume":"40","author":"Chen","year":"2022","journal-title":"J Adv Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"106645","DOI":"10.1016\/j.intimp.2020.106645","article-title":"Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway","volume":"85","author":"Tian","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"5872","DOI":"10.1021\/acs.jafc.4c07965","article-title":"Hawthorn pectin alleviates DSS-induced colitis in mice by ameliorating intestinal barrier function and modulating gut microbiota","volume":"73","author":"Li","year":"2025","journal-title":"J Agric Food Chem"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.3390\/ijms26062466","article-title":"Ganoderic acid ameliorates ulcerative colitis by improving intestinal barrier function via gut microbiota modulation","volume":"26","author":"Ye","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"eadh1641","DOI":"10.1126\/scisignal.adh1641","article-title":"The NF-\u03baB signaling system in the immunopathogenesis of inflammatory bowel disease","volume":"17","author":"Mukherjee","year":"2024","journal-title":"Sci Signal"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.3390\/molecules29092154","article-title":"Poria cocos attenuated DSS-induced ulcerative colitis via NF-\u03baB signaling pathway and regulating gut microbiota","volume":"29","author":"Song","year":"2024","journal-title":"Molecules"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"679897","DOI":"10.3389\/fimmu.2021.679897","article-title":"Kaempferol alleviates murine experimental colitis by restoring gut microbiota and inhibiting the LPS-TLR4-NF-\u03baB Axis","volume":"12","author":"Qu","year":"2021","journal-title":"Front Immunol"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"7611","DOI":"10.3390\/molecules28227611","article-title":"Galactooligosaccharide mediates NF-\u03baB pathway to improve intestinal barrier function and intestinal microbiota","volume":"28","author":"Xi","year":"2023","journal-title":"Molecules"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"116553","DOI":"10.1016\/j.biopha.2024.116553","article-title":"Safflower polysaccharide ameliorates acute ulcerative colitis by regulating STAT3\/NF-\u03baB signaling pathways and repairing intestinal barrier function","volume":"174","author":"Qi","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"956","DOI":"10.17179\/excli2021-3596","article-title":"Oxidative stress concept updated: definitions, classifications, and regulatory pathways implicated","volume":"20","author":"Lushchak","year":"2021","journal-title":"EXCLI J"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"9678625","DOI":"10.1155\/2022\/9678625","article-title":"Inhibiting ferroptosis: a novel approach for ulcerative colitis therapeutics","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxidative Med Cell Longev"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","article-title":"Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease","volume":"26","author":"Bourgonje","year":"2020","journal-title":"Trends Mol Med"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41575-018-0079-5","article-title":"Control and dysregulation of redox signalling in the gastrointestinal tract","volume":"16","author":"Campbell","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"102441","DOI":"10.1016\/j.redox.2022.102441","article-title":"Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice","volume":"56","author":"Guo","year":"2022","journal-title":"Redox Biol"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"156048","DOI":"10.1016\/j.phymed.2024.156048","article-title":"Puerarin ameliorates colitis by direct suppression of macrophage M1 polarization in DSS mice","volume":"135","author":"Tao","year":"2024","journal-title":"Phytomedicine"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"nwad309","DOI":"10.1093\/nsr\/nwad309","article-title":"Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation","volume":"10","author":"Wu","year":"2023","journal-title":"Natl Sci Rev"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1657620\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:28:24Z","timestamp":1759987704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1657620\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":81,"alternative-id":["10.3389\/fmed.2025.1657620"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1657620","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]},"article-number":"1657620"}}