{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:49:30Z","timestamp":1792648170590,"version":"4.5.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Esophageal dedifferentiated liposarcoma (DDLPS) is extremely rare. We report a case of esophageal dedifferentiated liposarcoma (DDLPS) measuring 12.5\u202f\u00d7\u202f3.0\u202f\u00d7\u202f2.8\u202fcm in a 62-year-old male presenting with a one-year history of progressive dysphagia. Esophagogastroduodenoscopy and computed tomography showed a large pedunculated submucosal tumor arising from the esophageal entrance and extending intraluminally to 35\u202fcm from the incisor teeth, partially obstructing the esophageal lumen. Curative endoscopic resection was successfully achieved using a novel technique employing an externally placed snare and nylon loop outside the endoscope, thereby avoiding traumatic surgical operation. Histopathologic examination showed that the giant tumor was composed of a differentiated lipomatous component adjacent to dedifferentiated spindle cells. Immunohistochemical analysis revealed spindle cells were positive for p16, CDK4, MDM2, CD34, and CD31. The differentiated lipomatous areas were positive for S-100. The definitive pathologic diagnosis confirmed a dedifferentiated liposarcoma, and the margin was negative. This represents the fifth reported case of esophageal DDLPS successfully managed through endoscopic resection. This externally deployed snare and nylon loop technique provides a viable and less invasive alternative for endoscopic resection of large pedunculated esophageal DDLPS. However, long-term follow-up is necessary to evaluate both therapeutic outcomes and prognosis fully.<\/jats:p>","DOI":"10.3389\/fmed.2025.1662503","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T04:13:24Z","timestamp":1756181604000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Curative endoscopic resection of giant esophageal dedifferentiated liposarcoma: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Mingqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.yasu.2015.04.002","article-title":"Principles in management of soft tissue sarcoma","volume":"49","author":"Crago","year":"2015","journal-title":"Adv Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40792-016-0219-5","article-title":"Successful resection of Giant esophageal Liposarcoma by endoscopic submucosal dissection combined with surgical retrieval: a case report and literature review","volume":"2","author":"Takiguchi","year":"2016","journal-title":"Surg Case Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1001\/archsurg.1983.01390090065015","article-title":"Gastrointestinal Lipomas","volume":"118","author":"Fernandez","year":"1983","journal-title":"Arch Surg (Chicago, Ill: 1960)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00428-009-0815-x","article-title":"Well-differentiated and dedifferentiated Liposarcomas","volume":"456","author":"Coindre","year":"2010","journal-title":"Virchows Arch"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00268-020-05789-4","article-title":"Esophageal lipoma and Liposarcoma: a systematic review","volume":"45","author":"Ferrari","year":"2021","journal-title":"World J Surg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ijscr.2019.10.006","article-title":"Giant pedunculated Oesophageal Liposarcomas: a review of literature and resection techniques","volume":"64","author":"Ng","year":"2019","journal-title":"Int J Surg Case Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.1055\/s-2006-944902","article-title":"Curative endoscopic resection of a huge pedunculated esophageal Liposarcoma","volume":"39","author":"Will","year":"2007","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12029-010-9174-8","article-title":"A first reported case of dedifferentiated Liposarcoma of the esophagus with molecular diagnosis","volume":"42","author":"Watkin","year":"2011","journal-title":"J Gastrointest Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"141693","DOI":"10.1155\/2012\/141693","article-title":"Dedifferentiated Liposarcoma arising in an esophageal polyp: a case report","volume":"2012","author":"Torres-Mora","year":"2012","journal-title":"Case Rep Gastrointest Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4081\/rt.2016.6791","article-title":"Dedifferentiated Liposarcoma of the esophagus: a case report and selected review of the literature","volume":"8","author":"Brett","year":"2016","journal-title":"Rare Tumors"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s12029-015-9767-3","article-title":"Rare Giant pedunculated Liposarcoma of the hypopharynx: case report and review of literature","volume":"47","author":"Riva","year":"2016","journal-title":"J Gastrointest Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/modpathol.2017.140","article-title":"Polypoid Fibroadipose tumors of the esophagus: 'Giant Fibrovascular polyp' or Liposarcoma? 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