{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:31:11Z","timestamp":1765175471562,"version":"3.46.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the correlation between cholesterol levels and 24-h dynamic blood pressure in postmenopausal women with osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ambulatory blood pressure monitoring was performed using a portable automated device, and cholesterol levels were measured using a fully automated biochemical analyzer. The relationship between cholesterol and blood pressure was analyzed using Shepherd\u2019s Pi correlation and generalized additive models (GAM) with piecewise linear regression to identify threshold effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the participants was 73\u202fyears. Shepherd\u2019s Pi correlation analysis revealed a negative correlation between total cholesterol (TC) and intact parathyroid hormone (iPTH), as well as between high-density lipoprotein cholesterol (HDL-C) and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -crosslaps. Using GAM and piecewise linear regression to identify threshold effects, we found that when TC was \u22655.5\u202fmmol\/L, it was significantly and positively associated with 24-h mean systolic blood pressure (SBP) (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f12.62, 95% CI: 5.23\u201320.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), as well as with diurnal and nocturnal mean SBP. Similarly, low-density lipoprotein cholesterol (LDL-C)\u202f\u2265\u202f3.9\u202fmmol\/L showed a positive correlation with multiple blood pressure parameters, including 24-mSBP (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f18.33, 95% CI: 5.93\u201330.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004), diastolic blood pressure (DBP), and both diurnal and nocturnal measurements. No significant associations were observed below these threshold values. In contrast, HDL-C\u202f&amp;lt;\u202f1\u202fmmol\/L was negatively correlated with 24-mSBP (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u221232.13, 95% CI: \u221257.67 to \u22126.60,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.014), but not with DBP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A threshold effect exists between cholesterol and blood pressure in postmenopausal osteoporosis patients. Elevated TC and LDL-C beyond specific thresholds, as well as low HDL-C, are associated with higher blood pressure levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1662973","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:28:58Z","timestamp":1765175338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between cholesterol and ambulatory blood pressure in postmenopausal osteoporotic patients: a post-hoc analysis of an observational study"],"prefix":"10.3389","volume":"12","author":[{"given":"Zebin","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yipin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1038\/s41440-024-01582-1","article-title":"Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku medical megabank community-based cohort study","volume":"47","author":"Takase","year":"2024","journal-title":"Hypertens Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"895499","DOI":"10.3389\/fpubh.2022.895499","article-title":"Relationship between lipid profiles and hypertension: a cross-sectional study of 62,957 Chinese adult males","volume":"10","author":"Chen","year":"2022","journal-title":"Front Public Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/13697137.2023.2173568","article-title":"The effects of hormone replacement therapy on the microbiomes of postmenopausal women","volume":"26","author":"Dothard","year":"2023","journal-title":"Climacteric"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/s0021-9150(98)00252-4","article-title":"Coronary heart disease risk factors and menopause: a study in 1684 French women","volume":"142","author":"Tremollieres","year":"1999","journal-title":"Atherosclerosis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1161\/01.hyp.25.3.305","article-title":"Prevalence of hypertension in the US adult population. 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