{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:36:09Z","timestamp":1774668969850,"version":"3.50.1"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thyroid storm and acute liver failure (ALF) each independently carry high mortality rates. Previous literature has rarely reported cases of thyroid storm complicated by ALF, particularly in patients with low thyroid hormone levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient concerns<\/jats:title><jats:p>A 34-year-old woman was admitted to our hospital with fever and jaundice. The patient had been taking methimazole for four months following the diagnosis of hyperthyroidism. Upon admission, Laboratory tests revealed elevated liver enzymes and bilirubin levels. Then, she received liver-protective therapy along with medications to reduce liver enzymes and bilirubin, and antithyroid drugs were temporarily discontinued. Unfortunately, the patient subsequently developed thyroid storm and acute liver failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnosis<\/jats:title><jats:p>The patient was diagnosed with thyroid storm associated with acute liver failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>The patient remarkably improved with plasma exchange and corticosteroids treatment and radioactive iodine therapy was performed two months later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>The patient was regularly followed up after discharge and remained clinically stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lessons<\/jats:title><jats:p>This case highlights the importance of closely monitoring liver function in patients with hyperthyroidism. In the event of thyroid storm or fulminant liver failure, the use of potentially life-saving interventions such as plasma exchange and corticosteroids should not be delayed.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2025.1668176","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T05:21:42Z","timestamp":1759728102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: A case of thyroid storm with lower FT3 and FT4 levels accompanied by acute liver failure"],"prefix":"10.3389","volume":"12","author":[{"given":"Dezhao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.ecl.2006.09.008","article-title":"Thyrotoxicosis and thyroid storm","volume":"35","author":"Nayak","year":"2006","journal-title":"Endocrinol Metab Clin N Am"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2147\/CEG.S39358","article-title":"Clinical spectrum and therapeutic approach to hepatocellular injury in patients with hyperthyroidism","volume":"6","author":"de Campos Mazo","year":"2013","journal-title":"Clin Exp Gastroenterol"},{"key":"ref3","first-page":"337","article-title":"Hepatic dysfunction in 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