{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T14:19:26Z","timestamp":1794320366623,"version":"4.9.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to examine the relationship between axial length (AL) and anterior segment biometry in Chinese children and adolescents with high axial myopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study was conducted involving 366,278 Chinese students aged 7 to 18\u202fyears from January 2020 to December 2022. The SUOER\n                      <jats:italic>\u03bc<\/jats:italic>\n                      -Meter optical biometric was used for measuring ocular biometric parameters. A multivariate linear regression model was used to examine the correlation with AL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the participants, 28,877 exhibited high axial myopia (AL\u202f\u2265\u202f26\u202fmm). The average keratometry (K) and lens thickness (LT) in the high axial myopia group were significantly lower than those in both the non-myopia and normal myopia groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Central corneal thickness (CCT) and anterior chamber depth (ACD) were significantly greater in the high axial myopia group compared to both non-myopia and normal myopia groups (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Multivariate linear regression analysis demonstrated that K (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.265), CCT (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f0.001), ACD (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f1.609), and LT (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.607) were all correlated with AL (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). After adjusting for gender and age, when AL was &amp;lt;27\u202fmm, AL was negatively correlated with LT; similarly, when AL exceeded 27\u202fmm, there was no linear correlation between AL and LT (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In Chinese children and adolescents, a high AL (i.e., \u226526\u202fmm) was associated with significantly lower K, thicker CCT, and deeper ACD, and thinner LT compared with subjects having AL\u202f&amp;lt;\u202f26\u202fmm. When AL was &amp;lt;27\u202fmm, LT thinning may contribute to myopia compensation; however, when AL exceeds 27\u202fmm, this compensatory effect of crystalline lens thickness appears to diminish.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1671451","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:35:31Z","timestamp":1768286131000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between axial length and anterior segment biometry in high axial myopic Chinese students aged 7 to 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