{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:38:50Z","timestamp":1776893930099,"version":"3.51.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) is common in older adults and has been linked to Alzheimer\u2019s disease (AD). Plasma amyloid-\u03b2 oligomers (A\u03b2Os) may clarify this relationship. We evaluated whether preoperative A\u03b2O burden is associated with POD severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center prospective pilot study, we enrolled 22 patients aged \u226565 years undergoing hip or knee arthroplasty under general anesthesia. Blood was drawn preoperatively and postoperatively to quantify oligomerized amyloid-\u03b2 using the multimer detection system (MDS-Oa\u03b2). POD was assessed with the Korean version of the Delirium Rating Scale-98 (K-DRS-98). Group comparisons and correlations examined associations between MDS-Oa\u03b2 and POD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven of 22 patients developed POD. Those with POD were older and had higher preoperative MDS-Oa\u03b2 than those without POD (0.81 vs 0.56 ng\/mL). There was no significant perioperative change in MDS-Oa\u03b2, suggesting surgery or anesthesia did not alter the plasma A\u03b2 oligomerization tendency. Within the POD group, preoperative MDS-Oa\u03b2 correlated with both K-DRS-98 severity and total scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      In this pilot cohort, higher preoperative A\u03b2O burden was associated with the occurrence and severity of POD, while perioperative factors did not measurably affect A\u03b2O levels. These findings support a potential mechanistic link between AD-related pathology and POD. Given the small sample (\n                      <jats:italic>N<\/jats:italic>\n                      =22), estimates are imprecise and hypothesis-generating; validation in larger, multicenter studies is required before clinical application.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1673496","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:21:00Z","timestamp":1761546060000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A prospective pilot study on plasma amyloid beta oligomers and postoperative delirium"],"prefix":"10.3389","volume":"12","author":[{"given":"YoungSoon","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Tae","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/EJA.0000000000000107","article-title":"Postoperative delirium is an independent risk factor for post-traumatic stress disorder in elderly patients: a prospective observational study","volume":"32","author":"Drews","year":"2015","journal-title":"Eur J Anaesthesiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.jtcvs.2015.10.114","article-title":"Delirium after surgical and transcatheter aortic valve replacement is associated with increased mortality","volume":"151","author":"Maniar","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1001\/jamasurg.2015.2606","article-title":"Effect of delirium and other major complications on outcomes after elective surgery in older adults","volume":"150","author":"Gleason","year":"2015","journal-title":"JAMA Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/ccd.26776","article-title":"The impact of delirium on healthcare utilization and survival after transcatheter aortic valve replacement","volume":"89","author":"Huded","year":"2017","journal-title":"Catheter Cardiovasc Interv"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.jalz.2016.03.005","article-title":"The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients","volume":"12","author":"Inouye","year":"2016","journal-title":"Alzheimers Dement"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e0136071","DOI":"10.1371\/journal.pone.0136071","article-title":"Risk factors and outcomes for postoperative delirium after major surgery in elderly patients","volume":"10","author":"Raats","year":"2015","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1097\/CCM.0b013e3181f17bcb","article-title":"Cognitive decline following major surgery is associated with gliosis, \u03b2-amyloid accumulation, and \u03c4 phosphorylation in old mice","volume":"38","author":"Wan","year":"2010","journal-title":"Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1097\/00000542-200409000-00019","article-title":"Inhaled anaesthetic enhancement of amyloid-\u03b2 oligomerization and cytotoxicity","volume":"101","author":"Eckenhoff","year":"2004","journal-title":"Anesthesiology"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S1474-4422(15)00101-5","article-title":"The interface between delirium and dementia in elderly adults","volume":"14","author":"Fong","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neurobiolaging.2017.09.020","article-title":"Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study","volume":"61","author":"Rolandi","year":"2018","journal-title":"Neurobiol Aging"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1016\/j.bja.2021.12.014","article-title":"Amyloid deposition on positron-emission tomography correlates with severity of perioperative delirium: a case-control pilot study","volume":"128","author":"Torres-Vel\u00e1zquez","year":"2022","journal-title":"Br J Anaesth"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/alzrt226","article-title":"Amyloid \u03b2-protein oligomers and Alzheimer\u2019s disease","volume":"5","author":"Hayden","year":"2013","journal-title":"Alzheimer's Res Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.bja.2023.01.020","article-title":"Prospective analysis of plasma amyloid beta and postoperative delirium in the interventions for postoperative delirium: Biomarker-3 study","volume":"130","author":"Payne","year":"2023","journal-title":"Br J Anaesth"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"100401","DOI":"10.1016\/j.pcorm.2024.100401","article-title":"Bridging the gaps in understanding POD and POCD: a thorough examination of genetic and clinical biomarkers","volume":"35","author":"Figueiredo","year":"2024","journal-title":"Perioper Care Oper Room Manag"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"749","DOI":"10.2147\/CIA.S312473","article-title":"Plasma amyloid-\u03b2 oligomerization tendency predicts amyloid PET positivity","volume":"16","author":"Pyun","year":"2021","journal-title":"Clin Interv 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version of the delirium rating scale-Revised-98: reliability and validity","volume":"8","author":"Lee","year":"2011","journal-title":"Psychiatry Investig"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13195-017-0310-6","article-title":"Dynamic changes of oligomeric amyloid \u03b2 levels in plasma induced by spiked synthetic A\u03b242","volume":"9","author":"An","year":"2017","journal-title":"Alzheimer's Res Ther"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.nbd.2009.05.024","article-title":"Soluble fibrillar oligomer levels are elevated in Alzheimer\u2019s disease brain and correlate with cognitive dysfunction","volume":"35","author":"Tomic","year":"2009","journal-title":"Neurobiol Dis"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/EJA.0000000000001933","article-title":"Associations between Alzheimer\u2019s disease biomarkers and postoperative delirium or cognitive dysfunction: a meta-analysis and trial sequential analysis of prospective clinical trials","volume":"41","author":"Geng","year":"2024","journal-title":"Eur J Anaesthesiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1097\/SLA.0000000000002684","article-title":"CSF \u03b2-amyloid 1-42 concentration predicts delirium following elective arthroplasty surgery in an observational cohort study","volume":"269","author":"Cunningham","year":"2019","journal-title":"Ann Surg"}],"container-title":["Frontiers in 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