{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:52:34Z","timestamp":1763617954744,"version":"3.45.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Giant intracranial\n                    <jats:italic>Brucella<\/jats:italic>\n                    abscess is a severe and rare central nervous system infection whose pathogenesis remains incompletely understood. We detail the case of a 75-years-old urban male without\n                    <jats:italic>Brucella<\/jats:italic>\n                    exposure history who presented with fever and headache. Initial attribution of cephalgia to head trauma delayed diagnosis and treatment. Magnetic resonance imaging, metagenomic next-generation sequencing, and cerebrospinal fluid culture confirmed rapid development of a giant\n                    <jats:italic>Brucella<\/jats:italic>\n                    abscess (31 mm \u00d7 58 mm) within 2 weeks after head trauma. Head trauma may be potentially associated with the formation of\n                    <jats:italic>Brucella<\/jats:italic>\n                    brain abscess. Consequently, brucellosis patients with recent head trauma may warrant vigilant monitoring for this rare complication. It is imperative to avoid the premature attribution of headache to head trauma in such patients, as such an oversight risks delaying the diagnosis and management of a\n                    <jats:italic>Brucella<\/jats:italic>\n                    brain abscess.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1676548","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:11:09Z","timestamp":1763615469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant intracranial Brucella abscess after head trauma: a Case Report of neurobrucellosis in an urban elderly male without exposure history"],"prefix":"10.3389","volume":"12","author":[{"given":"Yanlang","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.3201\/eid2909.230052","article-title":"Global estimate of human brucellosis incidence.","volume":"29","author":"Laine","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e05672021","DOI":"10.1590\/0037-8682-0567-2021","article-title":"Neurobrucellosis: the great mimicker.","volume":"55","author":"Soares","year":"2022","journal-title":"Rev Soc Bras Med Trop"},{"key":"B3","first-page":"460","article-title":"Epidemiological evolution profile of human brucellosis and socioeconomic factor correlation analysis - Southern and Northern Areas, China, 1950-2021.","volume":"7","author":"Liu","year":"2025","journal-title":"China CDC Wkly"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1136674","DOI":"10.3389\/fcimb.2023.1136674","article-title":"Research progress on complications of Brucellosis.","volume":"13","author":"Jin","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/QCO.0000000000000920","article-title":"Neurobrucellosis.","volume":"36","author":"Soares","year":"2023","journal-title":"Curr Opin Infect Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"36045869","DOI":"10.1016\/j.amsu.2022.104278","article-title":"Neurobrucellosis presenting with the features of meningoencephalitis: a case report from Nepal.","volume":"80","author":"Acharya","year":"2022","journal-title":"Ann Med Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/NRL.0000000000000348","article-title":"Neurobrucellosis: brief Review.","volume":"26","author":"Bouferraa","year":"2021","journal-title":"Neurologist"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1056\/NEJMra050570","article-title":"Brucellosis.","volume":"352","author":"Pappas","year":"2005","journal-title":"N Engl J Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/cid\/cit072","article-title":"Neurobrucellosis: clinical and diagnostic features.","volume":"56","author":"Guven","year":"2013","journal-title":"Clin Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3760\/cma.j.cn112137-20240721-01683","article-title":"[Expert consensus on the diagnosis and treatment of neurobrucellosis (2025 edition)].","volume":"105","year":"2025","journal-title":"Zhonghua Yi Xue Za Zhi."},{"key":"B11","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/BF01646416","article-title":"Brain abscess caused by Brucella abortus and Staphylococcus aureus in a child.","volume":"18","author":"Kalelio\u011flu","year":"1990","journal-title":"Infection"},{"key":"B12","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jocn.2005.06.012","article-title":"Brucellar brain abscess and bilateral arachnoid cysts, unilaterally complicated by subdural haematoma.","volume":"13","author":"Koc","year":"2006","journal-title":"J Clin Neurosci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.bjid.2015.12.010","article-title":"A rare cause of seizures: brucellar brain abscess.","volume":"20","author":"Yilmaz","year":"2016","journal-title":"Braz J Infect Dis"},{"key":"B14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aace.2023.10.005","article-title":"Pituitary abscess causing panhypopituitarism in a patient with neurobrucellosis: case Report.","volume":"10","author":"De la Pe\u00f1a-Sosa","year":"2023","journal-title":"AACE Clin Case Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.3171\/jns.1999.90.6.1142","article-title":"Pituitary abscess secondary to neurobrucellosis. 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