{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:37:15Z","timestamp":1765521435216,"version":"3.48.0"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC) is a chronic and recurrent inflammatory bowel disease. Current drug treatments are often associated with side effects, unstable efficacy, and high relapse rates. Therefore, exploring complementary and alternative therapies such as acupuncture is of significant importance for optimizing UC clinical management strategies. This study employs a network meta-analysis method to systematically compare the efficacy and safety of various acupuncture-related therapies in treating UC, aiming to provide evidence-based guidance for selecting the optimal clinical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched 8 databases for randomized controlled trials (RCTs) of acupuncture-related therapies for ulcerative colitis, including China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, China Biological Medicine (CBM), PubMed, EMbase, the Cochrane Library, and Web of Science. The total effective rate, Mayo score, Baron endoscopic score were used for primary outcomes, interleukin-6 (IL-6) levels, tumor necrosis factor-alpha (TNF-\u03b1) levels, and relapse rate were selected as secondary outcomes. The Cochrane risk of bias tool (RoB 2.0) was used to assess the quality of the articles, and StataMP 18 was used for statistical analysis. Heterogeneity and consistency were assessed, and the comparative effectiveness of different acupuncture interventions was ranked using Surface under the cumulative ranking curve (SUCRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 76 RCTs were included, involving 7,484 participants. Auricular acupressure combined with Chinese herbal medicine (AA + CHM) (RR 1.71, 95% CI: 1.47, 1.99, SUCRA = 99.9%) was shown to have effective to improving total effective rate. For Mayo score, the most effective intervention was acupuncture combination therapy (ACU-CT) (SMD \u20134.85, 95% CI: \u20136.66, \u20133.05, SUCRA = 97.5%). In terms of reducing Baron endoscopic score, ACU-CT (SMD-2.31, 95% CI: \u20133.81, \u20130.81, SUCRA = 84.1%) had the best efficacy. For IL-6 levels, warm acupuncture (WA) (SMD \u20133.10, 95% CI: \u20134.56, \u20131.65, SUCRA = 96.1%) showed the best efficacy. For TNF-\u03b1 levels, warm acupuncture combination therapy (WA-CT) (SMD \u20132.32, 95% CI: \u20134.54, \u20130.10, SUCRA = 76.8%) demonstrated the best efficacy. For recurrence rate, Acupuncture (ACU) (OR 0.15, 95% CI: 0.03, 0.65, SUCRA = 89.3%) achieved the greatest reductions. SUCRA analysis showed that WA, ACU-CT, WA-CT, and acupoint catgut embedding (ACE) ranked highest in most of the outcomes. Acupoint frequency statistics revealed that the most commonly used acupoints for treating UC were Tianshu (ST25), Zusanli (ST36), Shangjuxu (ST37), Zhongwan (CV12), Guanyuan (CV4), Dachangshu (BL25), Pishu (BL20), Shenque (CV8), Qihai (CV6), and Sanyinjiao (SP6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings may provide preliminary evidence-based guidance for acupuncture-related interventions as a potential complementary or alternative treatment for patients with UC, particularly those who have poor responses to conventional pharmaceutical treatment. In the future, more large-sample, high-quality RCTs are needed to further confirm the long-term efficacy and mechanisms of different acupuncture interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n                      , identifier CRD420251082924.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1676608","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:33:03Z","timestamp":1765521183000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative clinical efficacy of acupuncture-related therapies for ulcerative colitis: a systematic review and network meta-analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Longtao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyang","family":"Ru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative colitis in adults: a review.","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/s0140-6736(23)00966-2","article-title":"Ulcerative colitis.","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review.","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.5152\/tjg.2023.23103","article-title":"Salvage therapy in acute severe ulcerative colitis: current practice and a look to the future.","volume":"34","author":"Tamir-Degabli","year":"2023","journal-title":"Turk J Gastroenterol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1001\/jama.2023.23814","article-title":"What is ulcerative colitis?","volume":"331","author":"Voelker","year":"2024","journal-title":"JAMA."},{"key":"B6","doi-asserted-by":"publisher","first-page":"6091","DOI":"10.3390\/curroncol29090479","article-title":"Colorectal cancer in ulcerative colitis: mechanisms, surveillance and chemoprevention.","volume":"29","author":"Li","year":"2022","journal-title":"Curr Oncol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1053\/j.gastro.2016.10.036","article-title":"Etiology and treatment of pain and psychosocial issues in patients with inflammatory bowel diseases.","volume":"152","author":"Regueiro","year":"2017","journal-title":"Gastroenterology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1093\/ecco-jcc\/jjab010","article-title":"Efficacy of oral, topical, or combined oral and topical 5-aminosalicylates, in ulcerative colitis: systematic review and network meta-analysis.","volume":"15","author":"Barberio","year":"2021","journal-title":"J Crohns Colitis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/ajg.2011.70","article-title":"Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis.","volume":"106","author":"Ford","year":"2011","journal-title":"Am J Gastroenterol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis.","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat Rev Dis Primers."},{"key":"B11","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41573-024-00953-0","article-title":"Navigating the complexities of drug development for inflammatory bowel disease.","volume":"23","author":"Honap","year":"2024","journal-title":"Nat Rev Drug Discov."},{"key":"B12","doi-asserted-by":"publisher","first-page":"9458","DOI":"10.3748\/wjg.v20.i28.9458","article-title":"Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis.","volume":"20","author":"da Silva","year":"2014","journal-title":"World J Gastroenterol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.13460\/j.issn.1005-0957.2022.05.0443","article-title":"Observation on the efficacy of warm needling therapy combined with western medicine in the treatment of ulcerative colitis.","volume":"41","author":"Dongdong","year":"2022","journal-title":"Shanghai J Acupunct Moxibustion."},{"key":"B14","first-page":"1470","article-title":"Clinical study on warm acupuncture combined with bukou buxu decoction in the treatment of ulcerative colitis with spleen-kidney yang deficiency syndrome.","volume":"42","author":"Yanjun","year":"2021","journal-title":"Shaanxi J Traditional Chinese Med."},{"key":"B15","first-page":"1483","article-title":"The efficacy of warm acupuncture combined with Shenling Baizhu Powder in the treatment of ulcerative colitis with spleen deficiency and dampness obstruction syndrome and its effects on brain-gut interaction and inflammatory factors.","volume":"43","author":"Li","year":"2021","journal-title":"Hebei J Traditional Chinese Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.19621\/j.cnki.11-3555\/r.2021.0301","article-title":"Analysis of acupuncture treatment strategies for ulcerative colitis.","volume":"29","author":"Chao","year":"2021","journal-title":"China\u2019s Naturopathy."},{"key":"B17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.16808\/j.cnki.issn1003-7705.2018.01.084","article-title":"Research progress on the effects of acupuncture on intestinal microbiota.","volume":"34","author":"Luqiang","year":"2018","journal-title":"Hunan J Traditional Chinese Med."},{"key":"B18","first-page":"1912","article-title":"Research progress on the mechanism of acupuncture in treating ulcerative colitis.","volume":"14","author":"Wenrui","year":"2021","journal-title":"Global Traditional Chinese Med."},{"key":"B19","first-page":"74","article-title":"Research progress on acupoint therapy for ulcerative colitis.","volume":"45","author":"Zongri","year":"2021","journal-title":"Chinese J Library Inf Sci Traditional Chinese Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e20789","DOI":"10.1016\/j.heliyon.2023.e20789","article-title":"Electroacupuncture for ulcerative colitis patients: a meta-analysis and acupoints selection study.","volume":"9","author":"Hao","year":"2023","journal-title":"Heliyon."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e30945","DOI":"10.1097\/MD.0000000000030945","article-title":"Meta-analysis and trial sequential analysis of acupoint catgut embedding in the treatment of ulcerative colitis: acupoint catgut embedding treating ulcerative colitis meta-analysis.","volume":"101","author":"Yu","year":"2022","journal-title":"Medicine."},{"key":"B22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s12906-020-03101-4","article-title":"Acupuncture for ulcerative colitis: a systematic review and meta-analysis of randomized clinical trials.","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Complement Med Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-230X-10-36","article-title":"Moxibustion for ulcerative colitis: a systematic review and meta-analysis.","volume":"10","author":"Lee","year":"2010","journal-title":"BMC Gastroenterol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.","volume":"372","author":"Page","year":"2020","journal-title":"BMJ."},{"key":"B25","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations.","volume":"162","author":"Hutton","year":"2015","journal-title":"Ann Intern Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials.","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ."},{"key":"B27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. Rating the quality of evidence\u2013study limitations (risk of bias).","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1093\/ije\/dys041","article-title":"Predicting the extent of heterogeneity in meta-analysis, using empirical data from the Cochrane database of systematic reviews.","volume":"41","author":"Turner","year":"2012","journal-title":"Int J Epidemiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e066084","DOI":"10.1136\/bmj-2021-066084","article-title":"Drug treatment for panic disorder with or without agoraphobia: systematic review and network meta-analysis of randomised controlled trials.","volume":"376","author":"Chawla","year":"2022","journal-title":"BMJ."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3336","DOI":"10.1093\/eurheartj\/ehu424","article-title":"Systematic reviews and meta-analyses of randomized trials: principles and pitfalls.","volume":"35","author":"da Costa","year":"2014","journal-title":"Eur Heart J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/jrsm.1167","article-title":"Automated generation of node-splitting models for assessment of inconsistency in network meta-analysis.","volume":"7","author":"van Valkenhoef","year":"2016","journal-title":"Res Synth Methods."},{"key":"B32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial.","volume":"64","author":"Salanti","year":"2011","journal-title":"J Clin Epidemiol."},{"key":"B33","volume-title":"NICE DSU Technical Support Document 2: A Generalised Linear Modelling Framework for Pairwise and Network Meta-Analysis of Randomised Controlled Trials.","author":"Dias","year":"2014"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.13288\/j.11-2166\/r.2012.24.012","article-title":"Clinical observation of 33 cases of ulcerative colitis treated with jiawei baitouweng decoction for enteral drip combined with acupoint catgut embedding.","volume":"53","author":"Hongbo","year":"2012","journal-title":"J Traditional Chinese Med."},{"key":"B35","first-page":"282","article-title":"Acupuncture at jiaji points combined with plum-blossom needle tapping for treating 43 cases of ulcerative colitis.","volume":"44","author":"Yue","year":"2003","journal-title":"J Traditional Chinese Med."},{"key":"B36","first-page":"71","article-title":"Observation on the efficacy of acupuncture combined with modified scutellaria decoction in treating active ulcerative colitis (dampness-heat accumulation syndrome).","volume":"28","author":"Defang","year":"2022","journal-title":"Guide J Traditional Chinese Med Pharmacol."},{"key":"B37","first-page":"49","article-title":"Clinical observation of 40 cases of ulcerative colitis treated with meridian-focused moxibustion combined with Wenzhong Guyuan decoction.","volume":"15","author":"Min","year":"2009","journal-title":"J Traditional Chinese Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.16368\/j.issn.1674-8999.2021.06.280","article-title":"The effect of Baitouweng decoction combined with penetrating moxibustion on inflammatory cytokines and immune function in patients with damp-heat type ulcerative colitis.","volume":"36","author":"Puyu","year":"2021","journal-title":"J Traditional Chinese Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.13193\/j.archtcm.2008.09.230.zhougy.088","article-title":"Clinical observation of electroacupuncture combined with moxibustion and medication in the treatment of ulcerative colitis.","volume":"2008","author":"Guoying","year":"2008","journal-title":"J Traditional Chinese Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"844","DOI":"10.16766\/j.cnki.issn.1674-4152.002469","article-title":"Evaluation of the effect of lei\u2019s silver cup moxibustion with ginger partition combined with the fire-reinforcing earth-generating method on ulcerative colitis in remission.","volume":"20","author":"Baocai","year":"2022","journal-title":"Chinese General Pract."},{"key":"B41","first-page":"18","article-title":"Bioinformatics study on the mechanism of umbilical moxibustion therapy on the BTNL2-HLA signaling pathway in patients with ulcerative colitis.","volume":"26","author":"Wenwen","year":"2019","journal-title":"Chinese J Information Traditional Chinese Med."},{"key":"B42","first-page":"32","article-title":"Clinical study on herbal cake-separated moxibustion for mild to moderate ulcerative colitis with spleen deficiency and dampness accumulation syndrome.","volume":"24","author":"Zhouyu","year":"2017","journal-title":"Chinese J Inf Traditional Chinese Med."},{"key":"B43","first-page":"694","article-title":"Therapeutic efficacy of yu kuining formula enema combined with heat-sensitive moxibustion in the treatment of ulcerative colitis (dampness-heat accumulation syndrome) and its immunomodulatory mechanism.","volume":"30","author":"Yi","year":"2021","journal-title":"J Emerg Traditional Chinese Med."},{"key":"B44","first-page":"233","article-title":"Clinical study on the \u2018using fire to chase the dragon fire\u2019 method combined with he-mu point acupuncture for the treatment of acute ulcerative colitis.","volume":"27","author":"Qiang","year":"2018","journal-title":"J Emerg Traditional Chinese Med."},{"key":"B45","first-page":"58","article-title":"The effect of acupoint catgut embedding on serum IL-2 receptor and T lymphocyte subsets in patients with ulcerative colitis.","volume":"23","author":"Ying","year":"2003","journal-title":"Chinese J Integr Traditional Western Med."},{"key":"B46","first-page":"525","article-title":"Clinical observation of umbilical moxibustion therapy combined with mesalazine in the treatment of ulcerative colitis with spleen-kidney yang deficiency syndrome.","volume":"25","author":"Chunquan","year":"2017","journal-title":"Chinese J Integr Traditional Western Med Digestion."},{"key":"B47","first-page":"275","article-title":"Observation on the efficacy of combined acupuncture and moxibustion in treating 60 cases of ulcerative colitis.","author":"Sheng","year":"1997","journal-title":"Chinese Acupunct Moxibustion."},{"key":"B48","first-page":"97","article-title":"Clinical observation of shenque (CV8) herbal-cake-separated moxibustion therapy for ulcerative colitis.","volume":"26","author":"Songmei","year":"2006","journal-title":"Chinese Acupunct Moxibustion."},{"key":"B49","first-page":"261","article-title":"Clinical observation of acupoint catgut embedding therapy for ulcerative colitis.","author":"Hongjun","year":"2006","journal-title":"Chinese Acupunct Moxibustion."},{"key":"B50","first-page":"90","article-title":"Observation on the effect of Banxia Xiexin decoction combined with abdominal acupuncture in the treatment of mild to moderate active ulcerative colitis with dampness-heat syndrome of the large intestine.","volume":"19","author":"Jinjie","year":"2022","journal-title":"Med Innov China."},{"key":"B51","doi-asserted-by":"publisher","first-page":"315","DOI":"10.16466\/j.issn1005-5509.2015.04.019","article-title":"Comparison of the efficacy of acupuncture combined with oral Chinese herbal medicine in the treatment of chronic nonspecific ulcerative colitis.","volume":"39","author":"Ziying","year":"2015","journal-title":"J Zhejiang Chinese Med Univer."},{"key":"B52","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3969\/j.issn.1008-8849.2021.01.005","article-title":"The effect of regulating spleen and stomach with warming and cooling needling method on Th17\/Treg balance and cytokine levels in patients with ulcerative colitis.","volume":"30","author":"Yanjun","year":"2021","journal-title":"Modern J Integr Traditional Chinese Western Med."},{"key":"B53","first-page":"288","article-title":"The effect of acupoint catgut embedding therapy on the intestinal mucosa of patients with ulcerative colitis.","volume":"29","author":"Hong","year":"2020","journal-title":"Modern J Integr Traditional Chinese Western Med."},{"key":"B54","first-page":"43","article-title":"Analysis of the efficacy of acupuncture and moxibustion in traditional chinese medicine for treating chronic ulcerative colitis.","volume":"17","author":"Xue","year":"2020","journal-title":"Clin J Diabetes World."},{"key":"B55","first-page":"77","article-title":"Clinical observation on the treatment of ulcerative colitis with midnight-midday ebb-flow herbal retention enema combined with heat-sensitive moxibustion.","volume":"35","author":"Guiying","year":"2017","journal-title":"J Sichuan Traditional Chinese Med."},{"key":"B56","first-page":"95","article-title":"Clinical observation of bupiwei xieyinhuo shengyang decoction combined with heat-sensitive moxibustion in the treatment of ulcerative colitis.","volume":"35","author":"Liqun","year":"2017","journal-title":"J Sichuan Traditional Chinese Med."},{"key":"B57","first-page":"182","article-title":"Observation on the therapeutic effect of acupuncture for strengthening the spleen and nourishing the kidney in treating ulcerative colitis.","volume":"34","author":"Baojun","year":"2016","journal-title":"J Sichuan Traditional Chinese Med."},{"key":"B58","first-page":"89","article-title":"Clinical observation on specific acupoint thread embedding therapy for chronic non-specific ulcerative colitis.","author":"Jie","year":"2004","journal-title":"J Sichuan Traditional Chinese Med."},{"key":"B59","first-page":"199","article-title":"Randomized controlled study on moxibustion at shenque and bazhen acupoints combined with chinese herbal medicine enema in the treatment of ulcerative colitis.","volume":"35","author":"Yujie","year":"2017","journal-title":"J Sichuan Traditional Chinese Med."},{"key":"B60","first-page":"124","article-title":"Clinical study on tongxie yaofang combined with electroacupuncture in the treatment of ulcerative colitis with liver-spleen disharmony pattern.","volume":"38","author":"Hailin","year":"2020","journal-title":"J Sichuan Traditional Chinese Med."},{"key":"B61","first-page":"1564","article-title":"Observation on the efficacy of combined acupuncture and medication in treating mild to moderate non-specific ulcerative colitis.","volume":"16","author":"Tianshu","year":"2009","journal-title":"Pract Prevent Med."},{"key":"B62","first-page":"131","article-title":"Clinical observation of wumei pill combined with thunder-fire moxibustion in the treatment of ulcerative colitis.","volume":"20","author":"Lingyun","year":"2016","journal-title":"J Clin Med Pract."},{"key":"B63","doi-asserted-by":"publisher","first-page":"378","DOI":"10.13460\/j.issn.1005-0957.2019.04.0378","article-title":"Efficacy of acupuncture combined with chinese herbal medicine in the treatment of ulcerative colitis and its impact on related indicators.","volume":"38","author":"Wensong","year":"2019","journal-title":"Shanghai J Acupunct Moxibustion."},{"key":"B64","doi-asserted-by":"publisher","first-page":"374","DOI":"10.13460\/j.issn.1005-0957.2019.04.0374","article-title":"Observation on the efficacy of indirect moxibustion with aconite cake combined with mesalazine in the treatment of ulcerative colitis with damp-heat type.","volume":"38","author":"Qun","year":"2019","journal-title":"Shanghai J Acupunct Moxibustion."},{"key":"B65","first-page":"319","article-title":"Observation on the therapeutic effect of acupuncture at the Shizi point as the main treatment for ulcerative colitis.","volume":"31","author":"Qun","year":"2012","journal-title":"Shanghai J Acupunct Moxibustion."},{"key":"B66","first-page":"98","article-title":"Acupoint catgut embedding therapy for mild to moderate ulcerative colitis: a report of 34 cases.","volume":"36","author":"Zong","year":"2015","journal-title":"Shaanxi J Traditional Chinese Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3969\/j.issn.0257-358X.2008.05.009","article-title":"Comprehensive therapy for chronic ulcerative colitis: a clinical study of 42 cases.","volume":"27","author":"Hongfei","year":"2008","journal-title":"Shandong J Traditional Chinese Med."},{"key":"B68","first-page":"2097","article-title":"Clinical efficacy of indirect moxibustion combined with mesalazine in the treatment of ulcerative colitis and its effects on serum immunoglobulin, interleukin-17, and thromboxane B2.","volume":"17","author":"Weiwei","year":"2018","journal-title":"J Clin Exp Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"159","DOI":"10.13192\/j.issn.1000-1719.2024.06.042","article-title":"Clinical efficacy of Tongxie Decoction combined with acupuncture in the treatment of ulcerative colitis and its effects on serum inflammatory factors and intestinal flora.","volume":"51","author":"Jia","year":"2024","journal-title":"Liaoning J Traditional Chinese Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"173","DOI":"10.13192\/j.issn.1000-1719.2022.11.045","article-title":"Clinical study on electroacupuncture at dachangshu and front-mu points for ulcerative colitis.","volume":"49","author":"Hu","year":"2022","journal-title":"Liaoning J Traditional Chinese Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3969\/j.issn.1000-1719.2007.01.045","article-title":"Observation on the efficacy of combining acupuncture and medication in treating 89 cases of ulcerative colitis.","volume":"34","author":"Yanru","year":"2007","journal-title":"Liaoning J Traditional Chinese Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"811","DOI":"10.13192\/j.issn.1000-1719.2018.04.047","article-title":"Clinical value analysis of acupuncture combined with changyanqing in the treatment of ulcerative colitis with dampness-heat syndrome of large intestine in active stage.","volume":"45","author":"Longling","year":"2018","journal-title":"Liaoning J Traditional Chinese Med."},{"key":"B73","first-page":"44","article-title":"Clinical observation of 34 cases of ulcerative colitis treated with ginger-partitioned moxibustion.","author":"Juhua","year":"2003","journal-title":"Jiangsu J Traditional Chinese Med."},{"key":"B74","first-page":"65","article-title":"Study on the mechanism of electroacupuncture combined with drug therapy in the treatment of UC based on the brain-gut axis\u2014with 31 clinical cases included.","volume":"46","author":"Fei","year":"2014","journal-title":"Jiangsu J Traditional Chinese Med."},{"key":"B75","first-page":"270","article-title":"Observation on the efficacy of traditional chinese medicine retention enema combined with acupuncture in the treatment of ulcerative colitis.","volume":"32","author":"Runlian","year":"2012","journal-title":"Jilin J Chinese Med."},{"key":"B76","first-page":"1970","article-title":"Study on the effect of heat-sensitive moxibustion combined with kangfuxin liquid enema in the treatment of ulcerative colitis.","volume":"27","author":"Yan","year":"2013","journal-title":"Chinese Nurs Res."},{"key":"B77","first-page":"338","article-title":"Clinical observation on treating ulcerative colitis from the perspective of the lung using Jingjie Lianqiao decoction combined with acupuncture at Guiyan point.","volume":"43","author":"Chunxia","year":"2023","journal-title":"J Hunan Univer Chinese Med."},{"key":"B78","first-page":"78","article-title":"Clinical efficacy of Qingre Huashi decoction combined with acupuncture in the treatment of ulcerative colitis and its effect on serum inflammatory factors.","volume":"22","author":"Haiping","year":"2020","journal-title":"J Hubei Univer Chinese Med."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.16367\/j.issn.1003-5028.2014.12.067","article-title":"Combination of patrinia mixture and dense wave electroacupuncture in the treatment of 40 cases of ulcerative colitis.","volume":"34","author":"Yang","year":"2014","journal-title":"Henan Traditional Chinese Med."},{"key":"B80","first-page":"538","article-title":"50 cases of chronic non-specific ulcerative colitis treated with qi-replenishing, blood-activating, and collateral-dredging formula combined with scalp acupuncture.","volume":"31","author":"Hongchang","year":"2009","journal-title":"Hebei J Traditional Chinese Med."},{"key":"B81","article-title":"Acupuncture combined with drug enema in the treatment of 40 cases of chronic ulcerative colitis.","volume":"852","author":"Shiqiang","year":"2001","journal-title":"Hebei J Traditional Chinese Med."},{"key":"B82","first-page":"212","article-title":"Clinical observation of Lian Yang San retention enema combined with acupuncture therapy in the treatment of chronic non-specific ulcerative colitis.","volume":"36","author":"Yanhua","year":"2014","journal-title":"Hebei J Traditional Chinese Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"687","DOI":"10.13359\/j.cnki.gzxbtcm.2015.04.024","article-title":"Clinical efficacy of acupuncture combined with umbilical ring moxibustion with ginger for spleen-kidney yang deficiency ulcerative colitis and its effects on related inflammatory factors.","volume":"32","author":"Jun","year":"2015","journal-title":"J Guangzhou Univer Traditional Chinese Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.19945\/j.cnki.issn.1006-3250.2012.09.042","article-title":"Colonic drip combined with ginger-partitioned moxibustion in the treatment of ulcerative colitis: a clinical observation.","volume":"18","author":"Jianping","year":"2012","journal-title":"J Basic Chinese Med."},{"key":"B85","first-page":"879","article-title":"The therapeutic effect of Huangqi Jianzhong decoction combined with moxibustion on patients with ulcerative colitis of spleen deficiency and dampness accumulation type and its impact on T cell subsets.","volume":"29","author":"Sha","year":"2021","journal-title":"Chinese J Integr Traditional Western Med Digestion."},{"key":"B86","first-page":"168","article-title":"Acupuncture combined with herbal enema in the treatment of 45 cases of ulcerative colitis.","volume":"7","author":"Guangquan","year":"2010","journal-title":"Med Innov China."},{"key":"B87","first-page":"6","article-title":"Clinical observation of the therapeutic effect of comprehensive acupuncture and moxibustion therapy on ulcerative colitis.","volume":"22","author":"Hong","year":"2016","journal-title":"Psychol Doctor."},{"key":"B88","doi-asserted-by":"publisher","first-page":"3901","DOI":"10.3969\/j.issn.1008-8849.2020.35.006","article-title":"Observation on the efficacy of regulating the spleen and stomach with warming and cooling acupuncture based on the theory of \u201cearth as the pivot and four phenomena, one qi circulating\u201d in the treatment of ulcerative colitis.","volume":"29","author":"Yanjun","year":"2020","journal-title":"Modern J Integr Traditional Chinese Western Med."},{"key":"B89","first-page":"763","article-title":"Observation on the efficacy of modified shaoyao decoction combined with acupuncture in treating active ulcerative colitis with dampness-heat accumulation syndrome.","volume":"29","author":"Kun","year":"2020","journal-title":"Modern J Integr Traditional Chinese Western Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"5205","DOI":"10.1016\/j.phymed.2023.155052","article-title":"Observation on the efficacy of traditional Chinese medicine in treating and nursing ulcerative colitis.","author":"Hong","year":"2008","journal-title":"Modern J Integr Traditional Chinese Western Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"970","DOI":"10.13935\/j.cnki.sjzx.170720","article-title":"Randomized controlled study on the treatment of ulcerative colitis with traditional Chinese medicine retention enema combined with moxibustion.","volume":"12","author":"Liqun","year":"2017","journal-title":"World J Integr Traditional Western Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"63","DOI":"10.13460\/j.issn.1005-0957.2015.09.0858","article-title":"The effect of combined acupuncture and medication on T cell subsets in patients with ulcerative colitis.","volume":"34","author":"Jiannan","year":"2015","journal-title":"Shanghai J Acupunct Moxibustion."},{"key":"B93","first-page":"410","article-title":"Observation on the efficacy of kuijie formula combined with medicinal partition moxibustion in the treatment of ulcerative colitis with dampness-heat in the large intestine.","volume":"44","author":"Weiwei","year":"2020","journal-title":"J Shandong Univer Traditional Chinese Med."},{"key":"B94","first-page":"72","article-title":"Clinical observation of acupuncture at mu points combined with oral mesalazine in the treatment of ulcerative colitis.","volume":"45","author":"Chunling","year":"2024","journal-title":"J Kunming Med Univer."},{"key":"B95","first-page":"700","article-title":"Clinical study on modified Zhenren Yangzang decoction combined with moxibustion for ulcerative colitis with spleen-kidney yang deficiency syndrome.","volume":"42","author":"Hao","year":"2020","journal-title":"Hebei J Traditional Chinese Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"586","DOI":"10.13359\/j.cnki.gzxbtcm.2022.03.021","article-title":"Clinical observation of acupuncture combined with modified Shenling Baizhu powder in the treatment of ulcerative colitis with spleen deficiency and dampness-heat syndrome.","volume":"39","author":"Haiyan","year":"2022","journal-title":"J Guangzhou Univer Traditional Chinese Med."},{"key":"B97","first-page":"1784","article-title":"Stellate ganglion block combined with acupoint catgut embedding for ulcerative colitis.","volume":"17","author":"Bing","year":"2013","journal-title":"Anhui Med Pharm J."},{"key":"B98","doi-asserted-by":"publisher","first-page":"330","DOI":"10.13288\/j.11-2166\/r.2009.04.038","article-title":"Treatment of 50 cases of chronic ulcerative colitis with the method of Tonifying Qi, activating blood circulation, and dredging collaterals combined with scalp acupuncture therapy.","volume":"50","author":"Shukai","year":"2009","journal-title":"J Traditional Chinese Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"314","DOI":"10.3321\/j.issn:1001-1668.2008.04.010","article-title":"Clinical efficacy observation of combining acupuncture and medicine in treating 89 cases of ulcerative colitis.","volume":"49","author":"Yanru","year":"2008","journal-title":"J Traditional Chinese Med."},{"key":"B100","first-page":"220","article-title":"Observation on the Efficacy of Scalp Acupuncture Combined with Sulfasalazine in the Treatment of 46 Cases of Chronic Ulcerative Colitis.","volume":"19","author":"Hongchang","year":"2010","journal-title":"J Emerg Traditional Chinese Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.3321\/j.issn:1001-5302.2008.20.029","article-title":"The effect of combining acupoint therapy with medication on clinical efficacy and SOD, NO levels in patients with ulcerative colitis (UC).","volume":"33","author":"Yanru","year":"2008","journal-title":"China J Chinese Materia Med."},{"key":"B102","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11726-023-1357-5","article-title":"Clinical efficacy of moxibustion in the treatment of ulcerative colitis and its effect on vitamin D receptors.","volume":"21","author":"Xiaoying","year":"2023","journal-title":"J Acupunct Tuina Sci."},{"key":"B103","first-page":"1127","article-title":"40 cases of ulcerative colitis treated with changning enema combined with Du Moxibustion.","volume":"33","author":"Xiangdong","year":"2021","journal-title":"Shaanxi J Traditional Chinese Med."},{"key":"B104","first-page":"721","article-title":"Clinical observation on acupoint catgut embedding combined with modified pulsatilla decoction enema in the treatment of chronic non-specific ulcerative colitis.","volume":"34","author":"Dongjiang","year":"2012","journal-title":"Hebei J Traditional Chinese Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"9","DOI":"10.16588\/j.cnki.issn1002-1108.2001.04.009","article-title":"36 cases of chronic nonspecific ulcerative colitis treated with herbal enema combined with acupuncture.","volume":"12","author":"Jian","year":"2001","journal-title":"J Guizhou Univer Traditional Chinese Med."},{"key":"B106","first-page":"161","article-title":"Clinical study on the combination of Chinese and western medicine retention enema with acupuncture in the treatment of ulcerative colitis.","author":"Xiaolan","year":"2008","journal-title":"J Colorectal Anal Surg."},{"key":"B107","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/b978-0-12-405211-6.00004-8","article-title":"Mucosal healing in ulcerative colitis: pathophysiology and pharmacology.","volume":"59","author":"Seidelin","year":"2013","journal-title":"Adv Clin Chem."},{"key":"B108","first-page":"44","article-title":"The correlation between intestinal flora distribution and serum TNF-\u03b1 and IL-6 levels in patients with ulcerative colitis.","volume":"44","author":"Ziyu","year":"2024","journal-title":"Chinese J Coloproctol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"819","DOI":"10.13460\/j.issn.1005-0957.2019.08.0819","article-title":"Study on the regulatory effect of moxibustion pretreatment at Tianshu (ST25) acupoint on the TLR4\/TRIF signaling pathway in the colon of rats with ulcerative colitis.","volume":"38","author":"Ling","year":"2019","journal-title":"Shanghai J Acupunct Moxibustion."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1767301","DOI":"10.1155\/2017\/1767301","article-title":"Effects of herb-partitioned moxibustion on the mirna expression profiles in colon from rats with DSS-induced ulcerative colitis.","volume":"2017","author":"Huang","year":"2017","journal-title":"Evid Based Complement Alternat Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"8528938","DOI":"10.1155\/2022\/8528938","article-title":"A review on the immunomodulatory mechanism of acupuncture in the treatment of inflammatory bowel disease.","volume":"2022","author":"Liu","year":"2022","journal-title":"Evid Based Complement Alternat Med."},{"key":"B112","doi-asserted-by":"publisher","first-page":"158","DOI":"10.13193\/j.issn.1673-7717.2022.09.035","article-title":"Research progress on the pathogenesis and integrated traditional Chinese and Western medicine treatment of ulcerative colitis.","volume":"40","author":"Xueke","year":"2022","journal-title":"Chinese Arch Traditional Chinese Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/ibd\/izy371","article-title":"Acupuncture in inflammatory bowel disease.","volume":"25","author":"Song","year":"2019","journal-title":"Inflamm Bowel Dis."},{"key":"B114","doi-asserted-by":"publisher","first-page":"G192","DOI":"10.1152\/ajpgi.00254.2016","article-title":"Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis.","volume":"313","author":"Jin","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"6819","DOI":"10.3748\/wjg.v18.i46.6819","article-title":"Moxibustion inhibits interleukin-12 and tumor necrosis factor alpha and modulates intestinal flora in rat with ulcerative colitis.","volume":"18","author":"Wang","year":"2012","journal-title":"World J Gastroenterol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.13359\/j.cnki.gzxbtcm.2021.09.024","article-title":"Meta-analysis and trial sequential analysis of the efficacy of acupoint catgut embedding combined with Chinese Herbal medicine in the treatment of ulcerative colitis.","volume":"38","author":"Dongli","year":"2021","journal-title":"J Guangzhou Univer Chinese Med."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1676608\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T06:33:33Z","timestamp":1765521213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1676608\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":116,"alternative-id":["10.3389\/fmed.2025.1676608"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1676608","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"article-number":"1676608"}}