{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:37:22Z","timestamp":1764139042704,"version":"3.46.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Eradication of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      alone will not eliminate the risk of gastric cancer. There was no conclusive evidence that eradication therapy reduced the incidence of gastric cancer in patients with atrophic gastritis or intestinal metaplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      This study was conducted from March 2010 to September 2022, and enrolled 1,789 consecutive patients who underwent endoscopic submucosal dissection for gastric mucosal dysplasia. Patients who underwent two or more procedures for simultaneous or metachronous gastric epithelial dysplasia as high-risk groups for gastric cancer, and were confirmed to have\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection at the time of the procedure were included. Patients who received eradication treatment and underwent endoscopic follow-up for at least 2\u202fyears were included. The control group included patients who underwent endoscopic treatment for simple low-grade dysplasia. We investigated whether endoscopy was performed between 1 and 2\u202fyears after successful eradication of\n                      <jats:italic>H. pylori.<\/jats:italic>\n                      The endoscopic findings investigated were diffuse atrophy (open type), fundal atrophy, map-like redness, patch redness, erosions (body\/antrum), hematin, endoscopic reflux esophagitis, hematin, and duodenitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In univariate analysis, diffuse atrophy, map-like redness, and patchy redness at antrum after\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication were statistically different. In multivariate analysis, map-like redness [\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01, 95% confidence interval (CI) 1.83\u20137.59] and patchy redness at antrum (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.02, 95% CI 1.11\u20134.74) observed were statistically more frequent in patients with synchronous-metachronous gastric dysplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Map-like redness and patchy redness are newly identified endoscopic risk factors for gastric cancer in patients treated for\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1679012","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:34:54Z","timestamp":1764138894000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric mucosal change after the eradication of Helicobacter pylori in patients at high risk for gastric cancers"],"prefix":"10.3389","volume":"12","author":[{"given":"Na Rae","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Chul","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e12403","DOI":"10.1111\/hel.12403","article-title":"Epidemiology of Helicobacter pylori infection","volume":"22","author":"Burucoa","year":"2017","journal-title":"Helicobacter"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"ref3","first-page":"1","article-title":"IARC Monograph with institutional authorship (IARC Working Group). 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