{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:04:59Z","timestamp":1779375899242,"version":"3.53.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigates inflammatory markers and blood microflora in cirrhotic patients with portal vein thrombosis (PVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study explores inflammatory markers and microflora in cirrhotic patients with PVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study at Hebei General Hospital between September 2021 and December 2023 categorized patients into PVT and non-PVT groups. Portal and peripheral vein blood samples were collected during TIPS procedure, with inflammatory markers LPS, IL-6, IL-8, TNF\u03b1 and sNox2-dp tested via ELISA and 16SrRNA sequencing of blood microflora.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 28 cirrhotic patients: 12 in PVT group (5 males, mean age: 55.8 \u00b1 11.2) and 16 in non-PVT group (13 males, mean age: 54.3 \u00b1 13.6). Groups showed no differences in age, gender, or BMI(\n                      <jats:italic>P<\/jats:italic>\n                      &amp;gt; 0.05), but D-dimer levels were higher in PVT group (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Portal vein blood in PVT patients showed elevated LPS (34.42 vs. 13.59 pg\/mL), IL-6 (38.46 vs. 18.76 pg\/mL), TNF\u03b1 (46.74 vs. 18.92 pg\/mL), and sNox2-dp (13.03 vs. 5.13 pg\/mL) vs. non-PVT patients (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05), with no peripheral blood differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pseudomonas and Microbacteriaceae were enriched in PVT portal blood. Rolstonia, Clostridium, Phenylobacterium, and Streptococcus correlated with LPS and IL-6 (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05), while Phenylobacterium linked to D-dimer (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Cirrhotic patients with PVT show higher portal vein inflammatory markers due to bacterial translocation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1680970","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:11:59Z","timestamp":1768205519000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of inflammatory markers and microflora in cirrhotic patients with portal vein thrombosis: a retrospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Yanzhao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General Hospital","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunkai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Gastroenterology, Hebei General 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