{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:10:48Z","timestamp":1771920648997,"version":"3.50.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In this study, we sought to investigate the clinical manifestations, laboratory findings and radiographic features of severe\n                      <jats:italic>Chlamydia psittaci<\/jats:italic>\n                      pneumonia requiring invasive mechanical ventilation in the intensive care unit (ICU), as well as evaluate the role of fluoroquinolones in its treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed the clinical data of 14 patients diagnosed with severe\n                      <jats:italic>C. psittaci<\/jats:italic>\n                      pneumonia at Zhejiang University School of Medicine, Sir Run Run Shaw Hospital from December 2018 to November 2022. We collected the clinical characteristics, laboratory examination results, imaging features, treatment and prognosis. We used the SPSS 26.0 software to perform statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most patients presented high fever (\u226539 \u00b0C), shortness of breath and cough, as well as extrapulmonary symptoms such as fatigue, dizziness, muscle pain and headache. There were also significant increases in white blood cells, C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and D-dimer, while lymphocytes decreased significantly. Primary chest imaging features included consolidation, exudation and pleural effusion. All 14 patients received fluoroquinolones-based treatment and recovered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The clinical manifestations of severe\n                      <jats:italic>C. psittaci<\/jats:italic>\n                      pneumonia are nonspecific. Fluoroquinolones-based treatment may be effective in severe\n                      <jats:italic>C. psittaci<\/jats:italic>\n                      pneumonia with invasive mechanical ventilation in ICU. For severe cases of\n                      <jats:italic>C. psittaci<\/jats:italic>\n                      pneumonia, the treatment regimen may require an intravenous fluoroquinolone-based approach.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1682699","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:01:03Z","timestamp":1768312863000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical experience with fluoroquinolones for treatment of severe Chlamydia psittaci pneumonia with invasive mechanical ventilation in ICU: a retrospective study"],"prefix":"10.3389","volume":"12","author":[{"given":"Binbin","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Zhejiang University School of Medicine, Sir Run Run Shaw Hospital","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Anus and Intestine Surgery, The Tongde Hospital of Zhejiang Province","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1099\/mic.0.000097","article-title":"Chlamydia psittaci comparative genomics reveals intraspecies variations in the putative outer membrane and type III secretion system genes","volume":"161","author":"Wolff","year":"2015","journal-title":"Microbiology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s40121-020-00353-y","article-title":"Etiology of severe community-acquired pneumonia 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