{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:20:11Z","timestamp":1765995611275,"version":"build-2065373602"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Joint inflammation is a key manifestation of rheumatoid arthritis (RA), often leading to functional limitations and reduced quality of life (QoL) as the disease progresses. This study aims to examine the association between disease activity and health-related quality of life (HRQoL) in RA patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among 110 RA patients aged 18\u201365, diagnosed according to the 2010 ACR\/EULAR criteria and receiving disease-modifying antirheumatic drugs (DMARDs) therapy for at least 1\u2009month. Patient data were obtained from electronic medical records and verified through structured interviews. Health-related quality of life (HRQoL) was assessed using the EQ-5D-5L questionnaire, while disease activity was measured using the DAS28-ESR. Non-parametric analysis was performed to compare EQ-5D scores based on patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      The most frequently reported problem was pain\/discomfort (76.36%), showing significant differences across disease activity groups. Other commonly affected dimensions included usual activities (46.36%), anxiety\/depression (44.55%), mobility (33.64%), and self-care (19.09%). The mean EQ-5D index was 0.76 (95% CI, 0.73\u20130.80), and the visual analogue scale (VAS) score was 73.05 (95% CI, 69.91\u201376.19). Disease activity and comorbidity showed a statistically significant association with HRQoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009&amp;lt;0.001; OR\u2009=\u20096.33; CI 95% 2.29\u201317.51 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005; OR\u2009=\u20093.65; 95% CI 1.50\u20138.93, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that higher disease activity and comorbidity were negatively associated with HRQoL among RA patients. Disease progression disrupts multiple dimensions of quality of life of the subjects. This study highlights the importance HRQoL assessments in RA management to ensure a more comprehensive approach to patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1682924","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:22:31Z","timestamp":1761805351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Health-related quality of life and disease activity in rheumatoid arthritis: a cross-sectional study in West Java, Indonesia"],"prefix":"10.3389","volume":"12","author":[{"given":"Yudisia","family":"Ausi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rano K.","family":"Sinuraya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumartini","family":"Dewi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melisa I.","family":"Barliana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J.","family":"Postma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auliya A.","family":"Suwantika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/nrrheum.2010.86","article-title":"Geoepidemiology of autoimmune rheumatic diseases","volume":"6","author":"Shapira","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.autrev.2004.09.002","article-title":"Epidemiology of adult rheumatoid arthritis","volume":"4","author":"Alamanos","year":"2005","journal-title":"Autoimmun Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5218","DOI":"10.21037\/apm-20-2631b","article-title":"Drug discovery in rheumatoid arthritis with joint effusion identified by text mining and biomedical databases","volume":"10","author":"Li","year":"2021","journal-title":"Ann Palliat Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1002\/art.41752","article-title":"American College of Rheumatology Guideline for the treatment of rheumatoid arthritis","volume":"2021","author":"Fraenkel","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2147\/PPA.S189152","article-title":"Comparison of health-related quality of life in patients with rheumatoid arthritis during conventional or conventional plus biological therapy in Poland","volume":"13","author":"B\u0105k","year":"2019","journal-title":"Patient Prefer Adherence"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s40737-016-0069-2","article-title":"The meaning in quality of life","volume":"3","author":"Chaturvedi","year":"2016","journal-title":"J Psychosoc Rehabil Ment Health"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.15050","article-title":"Characteristics and prevalence of clinical remission of rheumatoid arthritis in a nationwide study from Indonesia","volume":"27","author":"Suryana","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"ref8","volume-title":"WHOQOL user manual","year":"1998"},{"key":"ref9","volume-title":"Global action plan for the prevention and control of non-communicable diseases 2013\u20132020","year":"2013"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s40273-017-0538-9","article-title":"The Indonesian EQ-5D-5L value set","volume":"35","author":"Purba","year":"2017","journal-title":"PharmacoEconomics"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/anr.1780320504","article-title":"A simplified twenty-eight\u2013joint quantitative articular index in rheumatoid arthritis","volume":"32","author":"Fuchs","year":"1989","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/rheumatology\/ket399","article-title":"Is radiographic progression of late-onset rheumatoid arthritis different from young-onset rheumatoid arthritis? 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