{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:56:30Z","timestamp":1763618190541,"version":"3.45.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Current operational criteria for Hansen\u2019s disease (HD), which are primarily based on lesion count and fixed-duration multidrug therapy, tend to overlook the neurological spectrum of the disease and fail to define cure in terms of functional recovery. The objective was to develop and validate a Sensitive Mapping Score using Semmes-Weinstein Monofilaments to assess and monitor cutaneous sensory impairment in HD lesions during treatment with the RIMOXCLAMIN regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective cohort of 40 patients was followed over a 12-month period. Tactile sensitivity was evaluated in the hands, feet, and cutaneous lesions at 3-month intervals using a standardized SWM mapping system. Color-coded responses were converted into a numerical score reflecting the degree of sensory impairment. Clinical, neurological, and laboratory parameters were assessed in parallel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although only 32.5% of patients met the multibacillary classification based on lesion count, 100% exhibited altered tactile sensation and 80% presented with nerve thickening. The SMS demonstrated early sensitivity to neurological improvement, with significant changes observed by the third month (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0156). By 12 months, 74.3% of lesions had achieved complete sensory recovery. The progression of SMS scores paralleled reductions in pain levels, nerve palpation abnormalities, and physical disability grades. No linear correlation was found with standard hand and feet scores, reinforcing the SMS\u2019s complementary value in capturing localized sensory recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SMS is a low-cost, accessible, and objective tool for neurological monitoring in HD. It quantifies functional recovery in cutaneous lesions, offering a clinically meaningful alternative to the concept of an \u201cadministrative cure.\u201d Its adoption could guide individualized treatment durations, enhance therapeutic decision-making, and promote a shift toward function-based definitions of cure in HD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1685347","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:12:13Z","timestamp":1763615533000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficiency of the Sensory Mapping Score for Hansens\u2019s disease diagnosis and follow-up: a functional cure criterion?"],"prefix":"10.3389","volume":"12","author":[{"given":"Marco Andrey Cipriani","family":"Frade","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Sartori","family":"Albertino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Vitor da Silva","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe Rocha","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0386","DOI":"10.1590\/0037-8682-0386-2021","article-title":"Innovative mapping of skin sensitivity by monofilaments to record the diagnosis and therapeutic follow-up of leprosy.","volume":"55","author":"Bernardes Filho","year":"2022","journal-title":"Rev Soc Bras Med Trop."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2019.12.080","article-title":"Leprosy: clinical aspects and diagnostic techniques.","volume":"83","author":"Maymone","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1590\/abd1806-4841.20142450","article-title":"Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - part 1.","volume":"89","author":"Last\u00f3ria","year":"2014","journal-title":"An Bras Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e5125986","DOI":"10.47820\/recima21.v5i12.5986","article-title":"Desafios da hansen\u00edase no contexto brasileiro com foco no nordeste: revis\u00e3o bibliogr\u00e1fica. recima21 [Challenges of leprosy in the Brazilian context with a focus on the Northeast: a literature review. recima21].","volume":"5","author":"Bortoluzzi","year":"2024","journal-title":"Rev Cient\u00edfica Multidisciplinar."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.11606\/issn.1679-9836.v102i2e-201518","article-title":"Hansen\u00edase em uma regi\u00e3o semi\u00e1rida da Bahia: uma an\u00e1lise de 2001 a 2017.","volume":"102","author":"Lima","year":"2023","journal-title":"Rev Med."},{"key":"B6","year":"2025","journal-title":"Leprosy \u2013 Number of New Leprosy Cases. 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