{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:34:22Z","timestamp":1764776062015,"version":"3.46.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The impact of hypertension (HT) of living donors on later kidney graft function remains insufficiently understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed recipients of living donor (LD) kidney transplant (KTX) at a single tertiary center from January 2003 to December 2021 with a follow-up until December 2022. LD blood pressure (BP) values obtained with office measurement and 24 h ambulatory BP monitoring (ABPM) were the main predictors, while recipient estimated glomerular filtration rate (eGFR) and proportion of kidney fibrosis on biopsies were the outcomes. Multivariate analyses were adjusted for pre-transplant donor characteristics: age, sex, ethnicity, body mass index (BMI) and eGFR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      212 LD KTX recipients were included, with mean age 51 years. 133 were women (62.7%). 73 (34.4%) LD were hypertensive based on office BP. In a sub-group of 112 LD with ABPM, 64 (57.1%) were hypertensive. Office systolic blood pressure (SBP) was negatively associated with eGFR at 6 months, 1 year, 5 years and 10 years (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05). Office SBP was positively associated with kidney fibrosis at 1 year (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05). Those associations were not significant after multivariate adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In conclusion, while an adverse impact of LD HT on later kidney function and fibrosis was measured, this effect seemed negligible after accounting for other more relevant clinical characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1686473","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:29:36Z","timestamp":1764775776000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of living donor hypertension on later function of kidney graft in kidney transplantation"],"prefix":"10.3389","volume":"12","author":[{"given":"Sophie","family":"Huegli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jaques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemie","family":"Grouzmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Hirt-Minkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange","family":"Moll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"de Seigneux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Ponte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Haidar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"ref1","volume-title":"Indicateurs_du_don_dorganes_Ext_23_4.pdf (swisstransplant.org)","year":"2023"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e051176","DOI":"10.1136\/bmjopen-2021-051176","article-title":"Cohort profile: the Swiss transplant cohort study (STCS): a Nationwide longitudinal cohort study of all solid organ recipients in Switzerland","volume":"11","author":"Stampf","year":"2021","journal-title":"BMJ Open"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1681\/ASN.2019090964","article-title":"Kidney structural features from living donors predict graft failure in the recipient","volume":"31","author":"Issa","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1097\/TP.0000000000001769","article-title":"KDIGO clinical practice guideline on the evaluation and Care of Living Kidney Donors","volume":"101","author":"Lentine","year":"2017","journal-title":"Transplantation"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/TP.0b013e318247a7b7","article-title":"British Transplantation Society, et renal association. summary of the British Transplantation Society\/renal association U.K. guidelines for living donor kidney transplantation","volume":"93","author":"Andrews","year":"2012","journal-title":"Transplantation"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1097\/HJH.0000000000003621","article-title":"2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European renal association (ERA) Erratum in: Journal of Hypertension 2024; 42(1):194","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e14293","DOI":"10.1111\/ctr.14293","article-title":"Renal function outcomes and kidney biopsy features of living kidney donors with hypertension","volume":"35","author":"Merzkani","year":"2021","journal-title":"Clin Transpl"},{"key":"ref8","first-page":"49","article-title":"Effect of donor hypertension on renal transplant recipients' blood pressure, allograft outcomes and survival: a systematic review and meta-analysis","volume":"9","author":"Altheaby","year":"2019","journal-title":"Am J Cardiovasc Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1097\/TP.0000000000002832","article-title":"Association between living kidney donor post-donation hypertension and recipient graft failure","volume":"104","author":"Holscher","year":"2020","journal-title":"Transplantation"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.transproceed.2018.02.003","article-title":"Living-donor kidney transplantation: donor-recipient function correlation","volume":"50","author":"Godinho","year":"2018","journal-title":"Transplant Proc"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/ctr.12294","article-title":"Long-term outcomes in African American kidney transplant recipients under contemporary immunosuppression: a four-Yr analysis of the mycophenolic acid observational REnal transplant (MORE) study","volume":"28","author":"Narayanan","year":"2014","journal-title":"Clin Transpl"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e92522","DOI":"10.1371\/journal.pone.0092522","article-title":"Epidemiology of masked and white-coat hypertension: the family-based SKIPOGH study","volume":"9","author":"Alwan","year":"2014","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40885-021-00172-4","article-title":"Utility of 24-hour ambulatory blood pressure monitoring in potential living kidney donors","volume":"27","author":"Aslam","year":"2021","journal-title":"Clin Hypertens"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"E437","DOI":"10.5489\/cuaj.4506","article-title":"Can zero-hour cortical biopsy predict early graft outcomes after living donor renal transplantation?","volume":"11","author":"Rathore","year":"2017","journal-title":"Can Urol Assoc J"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1016\/j.transproceed.2018.04.009","article-title":"Effect of donor age on graft function and pathologic findings in living donor transplantation","volume":"50","author":"Sekito","year":"2018","journal-title":"Transplant Proc"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1686473\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T15:29:37Z","timestamp":1764775777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1686473\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":15,"alternative-id":["10.3389\/fmed.2025.1686473"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1686473","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"article-number":"1686473"}}