{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:37:16Z","timestamp":1777081036612,"version":"3.51.4"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many patients with uveal melanoma (UM) cannot receive laboratory analysis due to eye-preserving treatment, biopsy risks or costs. The study is to evaluate correlation between tumor shape and a series of metastasis risks in UM, and to assess the predictive value of tumor shape classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four hundred thirty-nine UM patients undergoing enucleation were included in the study. Standardized echography was utilized to document selected tumor characteristics. Tumors were categorized into five distinct shape groups: mushroom, dome, lobulated, diffuse, and irregular. Clinical data, tumor thickness, largest basal diameter (LBD), American Joint Committee on Cancer (AJCC) stage, pathological results, and survival status were collected and comparatively analyzed across the different tumor shapes. Survival analysis was carried out with both Cox hazard regression and Kaplan\u2013Meier log rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 439 UM cases were classified as mushroom in 164 (37.4%), dome in 129 (29.4%), lobulated in 62 (14.1%), diffuse in 11 (2.5%) and irregular in 73 (16.6%). Significant differences were observed in tumor thickness, LBD, cell type, ciliary body involvement (CBI), extraocular extension, and AJCC stage across these shape categories. Regardless of tumor size and AJCC stage, mushroom-shaped melanoma exhibited the most favorable prognosis, irregular-shaped melanoma demonstrated the worst prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tumor shape could be defined noninvasively and dependably using echography. Shape classification in UM provides an independent variable to improve the clinical prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1687291","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:50:47Z","timestamp":1762775447000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights into shape of uveal melanoma: a comprehensive evaluation of clinical features, pathological features, and prognosis analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Heng","family":"Lou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingwen","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41572-020-0158-0","article-title":"Uveal melanoma","volume":"6","author":"Jager","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1001\/archophthalmol.2009.208","article-title":"Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes","volume":"127","author":"Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"101041","DOI":"10.1016\/j.preteyeres.2022.101041","article-title":"Metastatic uveal melanoma: the final frontier","volume":"90","author":"Rantala","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"102599","DOI":"10.1016\/j.ctrv.2023.102599","article-title":"Uveal melanoma: in the era of new treatments","volume":"119","author":"Wespiser","year":"2023","journal-title":"Cancer Treat Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/ceo.14214","article-title":"Current management of uveal melanoma: a review","volume":"51","author":"Bai","year":"2023","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.ophtha.2015.01.026","article-title":"American joint committee on Cancer classification of uveal melanoma (anatomic stage) predicts prognosis in 7731 patients","volume":"122","author":"Shields","year":"2015","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4103\/0301-4738.154367","article-title":"Uveal melanoma: estimating prognosis","volume":"63","author":"Kaliki","year":"2015","journal-title":"Indian J Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1097\/IAE.0b013e318285cd52","article-title":"Diffuse versus nondiffuse small (\u22643 MM thickness) choroidal melanoma: comparative analysis in 1,751 cases. 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Extrascleral extension of an uveal melanoma","volume":"49","author":"Grahn","year":"2008","journal-title":"Can Vet J"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1001\/archopht.1980.01020040827006","article-title":"Prognosis in uveal melanoma with extrascleral extension","volume":"98","author":"Affeldt","year":"1980","journal-title":"Arch Ophthalmol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1159\/000456718","article-title":"Mechanisms of optic nerve invasion in primary choroidal melanoma","volume":"3","author":"Szalai","year":"2017","journal-title":"Ocul Oncol Pathol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1167\/iovs.05-1435","article-title":"Optic nerve invasion of uveal melanoma: clinical characteristics and metastatic pattern","volume":"47","author":"Lindegaard","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.ophtha.2007.12.015","article-title":"Baseline echographic characteristics of tumors in eyes of patients enrolled in the collaborative ocular melanoma study: COMS report no. 29","volume":"115","author":"Boldt","year":"2008","journal-title":"Ophthalmology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/oxfordjournals.bmb.a072986","article-title":"Pathology of ocular melanomas","volume":"51","author":"McCartney","year":"1995","journal-title":"Br Med Bull"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0002-9394(98)00040-3","article-title":"Histopathologic characteristics of uveal melanomas in eyes enucleated from the collaborative ocular melanoma study COMS report no. 6","volume":"125","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1001\/archopht.1977.04450010065005","article-title":"Prognostic factors in choroidal and ciliary body melanomas","volume":"95","author":"Shammas","year":"1977","journal-title":"Arch Ophthalmol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/path.1711750110","article-title":"Components of the plasminogen activation system in uveal melanoma-a clinico-pathological study","volume":"175","author":"De Vries","year":"1995","journal-title":"J Pathol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1687291\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:50:49Z","timestamp":1762775449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1687291\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":47,"alternative-id":["10.3389\/fmed.2025.1687291"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1687291","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]},"article-number":"1687291"}}