{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:24:48Z","timestamp":1761171888936,"version":"build-2065373602"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Bronchiectasis is a chronic respiratory disorder characterized by irreversible airway dilation and recurrent infections, remains a therapeutic challenge. MSCs-exosomes based treatment is a potential treatment for respiratory disease; however, data regarding the efficacy of this novel therapy are currently lacking. We present a case of bronchiectasis treated with inhaled exosomes derived from human umbilical cord mesenchymal stem cells. As demonstrated in this patient, MSCs-exosomes inhalation may provide comprehensive benefits including reversal of hypoxemia, which could potentially result in enhancement of clinical outcomes and quality of life, and reduction in mortality.<\/jats:p>","DOI":"10.3389\/fmed.2025.1690559","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:17:45Z","timestamp":1761106665000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: successful treatment of severe bronchiectasis by inhalation of mesenchymal stem cell-derived 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