{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:41:05Z","timestamp":1767969665144,"version":"3.49.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated levels of Von Willebrand Factor (VWF) have been associated to an increased need of mechanical ventilation and higher mortality risk in COVID-19 patients, but the hypothesis of a shared genetic background has not been explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Common and low-frequency genetic variants belonging to the\n                      <jats:italic>VWF<\/jats:italic>\n                      ,\n                      <jats:italic>FVIII<\/jats:italic>\n                      , and\n                      <jats:italic>ADAMTS13<\/jats:italic>\n                      genes were tested for association with clinical variables related to severe COVID-19 disease in 9,371 European and 3,495 Latin-American patients. Gene\u2013environment and gene\u2013gene interactions were also explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A variant in the\n                      <jats:italic>VWF<\/jats:italic>\n                      gene was associated to the need of invasive mechanical ventilation (IMV) in the Latin-American population. Gene\u2013gene interaction models pointed to an interaction between\n                      <jats:italic>ADAMTS13<\/jats:italic>\n                      and\n                      <jats:italic>VWF<\/jats:italic>\n                      genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although we did not find significant associations among Europeans, we identified a low-frequency variant belonging to the\n                      <jats:italic>VWF<\/jats:italic>\n                      gene associated with the need of IMV in Latin-Americans.\n                    <\/jats:p>\n                  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