{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:53:09Z","timestamp":1791219189963,"version":"4.1.0"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    <jats:italic>Haemophilus influenzae<\/jats:italic>\n                    is a bacterium that typically colonizes the human respiratory tract. However, it can also infect the eyes, potentially leading to endophthalmitis. The general prognosis of endophthalmitis is often poor, frequently resulting in decreased visual acuity. We present the case of a 71-year-old male who experienced sudden blurring of vision, pain, and a significant hypopyon in the fundus of his right eye resulting from\n                    <jats:italic>Haemophilus influenzae<\/jats:italic>\n                    . According to previous reports, many cases of\n                    <jats:italic>Haemophilus influenzae<\/jats:italic>\n                    endophthalmitis have poor outcomes, often resulting in permanent visual impairment. However, the patient achieved an excellent prognosis in our case due to prompt diagnosis and emergent treatment.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1692870","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:21:01Z","timestamp":1761546061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: An endogenous endophthalmitis case caused by Haemophilus influenzae"],"prefix":"10.3389","volume":"12","author":[{"given":"Chia Hsuan","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Teh","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En Chi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yu","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih-Jin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1136\/bmj.282.6268.989-c","article-title":"Haemophilus influenzae endophthalmitis","volume":"282","author":"Boomla","year":"1981","journal-title":"Br Med J (Clin Res Ed)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3390\/jcm11051183","article-title":"Endogenous Endophthalmitis-the clinical significance of the primary source of infection","volume":"11","author":"Gajdzis","year":"2022","journal-title":"J Clin 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Endophthalmitis in an immunocompetent host","volume":"29","author":"Del Barrio","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3390\/microorganisms11020503","article-title":"Broad-Spectrum antimicrobial activity of Oftasecur and Visuprime ophthalmic solutions","volume":"11","author":"Dell\u2019Annunziata","year":"2023","journal-title":"Microorganisms"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1136\/bjo.86.3.276","article-title":"Biotypes and serotypes of Haemophilus influenzae ocular isolates","volume":"86","author":"Alrawi","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/09273948.2018.1466561","article-title":"Endogenous Endophthalmitis","volume":"26","author":"Cunningham","year":"2018","journal-title":"Ocul Immunol Inflamm"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s40123-021-00449-9","article-title":"A systematic review of multi-decade antibiotic resistance data for ocular bacterial pathogens in the United States","volume":"11","author":"Bispo","year":"2022","journal-title":"Ophthalmol Ther"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"107319","DOI":"10.1016\/j.ijantimicag.2024.107319","article-title":"The emergence of transposon-driven multidrug resistance in invasive nontypeable Haemophilus influenzae over the last decade","volume":"64","author":"Wan","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3341\/kjo.2017.0036","article-title":"Endophthalmitis","volume":"31","author":"Sheu","year":"2017","journal-title":"Korean J Ophthalmol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1692870\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T06:21:03Z","timestamp":1761546063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1692870\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":12,"alternative-id":["10.3389\/fmed.2025.1692870"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1692870","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"article-number":"1692870"}}