{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:15:25Z","timestamp":1763442925330,"version":"3.45.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The main purpose of this study is to describe a protocol to compare the effectiveness of MIRP and conventional rehabilitation treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/design<\/jats:title>\n                    <jats:p>\n                      The study will be a single-blinded pragmatic randomized controlled trial involving patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f100) with lung transplants. All patients will receive 6\u202fweeks of treatment, while they will be divided into two groups and receive MIRP (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f50) and conventional rehabilitation treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f50). Clinical functional assessment will be performed before, after intervention, and 3\u202fmonths after the enrollment, respectively. Adults who have undergone unilateral or bilateral lung transplants and have just returned to the regular ward from the intensive care unit are eligible to participate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The outcome of this study will provide a theoretical basis for clarifying intensive rehabilitation for lung transplants in future studies and clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.chictr.org.cn\/showproj.html?proj=177086<\/jats:uri>\n                      , identifier ChiCTR2200063538.\n                    <\/jats:p>\n                  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