{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:35:28Z","timestamp":1767591328157,"version":"3.48.0"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Wolf\u2019s post-herpetic isotopic response (PHIR) refers to the development of new cutaneous conditions, such as tumors, infections, or immune-mediated diseases, at the site of a previously healed herpetic eruption. The exact pathogenesis of Wolf\u2019s PHIR remains incompletely understood. Four hypotheses have been proposed regarding the mechanism of postherpetic inflammatory isomorphic reactions: viral, immunological, vascular, and neurological. In this case, we show that a patient with eczema developed it at the original site following the resolution of the herpes zoster infection. After 2\u202fweeks of systemic oral glucocorticoid treatment, the skin lesions improved significantly, and there was no recurrence during the 3-month follow-up.<\/jats:p>","DOI":"10.3389\/fmed.2025.1697012","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:31:00Z","timestamp":1767591060000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Wolf\u2019s isotopic response of eczema after herpes zoster infection: case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Yirui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.clindermatol.2010.09.015","article-title":"Wolf's isotopic response","volume":"29","author":"Wolf","year":"2011","journal-title":"Clin Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.clindermatol.2014.04.003","article-title":"Wolf's post-herpetic isotopic response: infections, tumors, and immune disorders arising on the site of healed herpetic infection","volume":"32","author":"Ruocco","year":"2014","journal-title":"Clin Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e109","DOI":"10.1016\/j.medcli.2024.02.028","article-title":"Postherpetic granuloma annulare: a Wolf's isotopic response","volume":"163","author":"Liu","year":"2024","journal-title":"Med Clin (Barc)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jaci.2016.12.980","article-title":"Substance P activates mas-related G protein-coupled receptors to induce itch","volume":"140","author":"Azimi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s12016-010-8225-z","article-title":"Atopic dermatitis and the nervous system","volume":"41","author":"Misery","year":"2011","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref6","first-page":"362","article-title":"Two cases of postherpetic Wolf\u2019s isotopic response","volume":"29","author":"Zijia","year":"2022","journal-title":"J Diagn Ther Dermatov"},{"key":"ref7","first-page":"476","article-title":"A case of eczema with infection following herpes zoster with Wolf's isotopic response","volume":"18","author":"Yijun","year":"2019","journal-title":"Chin J Dermatovenereol Integr Tradit West Med"},{"key":"ref8","first-page":"1089","article-title":"A case of eczematous changes after herpes zoster with Wolf's isotopic response","volume":"30","author":"Ling","year":"2016","journal-title":"Chin J Dermatovenereol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1697012\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:31:01Z","timestamp":1767591061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1697012\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":8,"alternative-id":["10.3389\/fmed.2025.1697012"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1697012","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"article-number":"1697012"}}