{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:12:41Z","timestamp":1771931561273,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to evaluate the outcomes of endovascular reperfusion followed by delayed open aortic repair in patients with acute type A aortic dissection (ATAAD) and malperfusion syndrome (MPS), as well as risk factors for mortality associated with organ failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively selected 777 patients with ATAAD admitted to our center. Patients with MPS (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f121; 15.6%), who were hemodynamically stable and without evidence of aortic rupture\/tamponade, underwent interventional reperfusion (IR) through aortic\/mesenteric branch stenting, followed by delayed open aortic repair (OR). Patients without MPS (non-MPS) (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f656; 84.4%) received immediate open aortic repair.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall hospital mortality was 37.2% in patients with ATAAD and MPS, significantly higher than in those without MPS (8.2%). However, patients with MPS who successfully underwent delayed repair after stenting had hospital mortality rates comparable to non-MPS patients (11.7% vs. 8.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.306) and similar short-term survival. Hypertension, leukocytosis, fibrin degradation products (FDP), D-dimer, and FDP\/D-dimer ratios were independent predictors of mortality associated with irreversible organ failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endovascular stenting followed by delayed open aortic repair in stable patients with ATAAD and MPS had favorable short-term outcomes. Stenting of the aorta and\/or aortic branches is a relatively simple, minimally invasive intervention with short-term patency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1701176","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:49:05Z","timestamp":1770821345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Endovascular reperfusion followed by delayed open aortic repair in stable acute type A aortic dissection with malperfusion syndrome: a single-center experience"],"prefix":"10.3389","volume":"12","author":[{"given":"Mengmeng","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]},{"name":"Department of Cardiac Surgery, The Second Hospital and Clinical Medical School, Lanzhou University","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University","place":["Xi'an, Shaanxi, China"]},{"name":"Department of Cardiac Surgery, The Second Hospital and Clinical Medical School, Lanzhou University","place":["Lanzhou, Gansu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1111\/jocs.16401","article-title":"Determinant of outcome in late presenting type A aortic dissection","volume":"37","author":"Shetty","year":"2022","journal-title":"J Card 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