{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:39:14Z","timestamp":1767681554270,"version":"3.48.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kunming Health Research Project","award":["2023-04-04-004"],"award-info":[{"award-number":["2023-04-04-004"]}]},{"name":"Scientific Research Fund Project of the Yunnan Provincial Department of Education","award":["2024J0374"],"award-info":[{"award-number":["2024J0374"]}]},{"name":"Scientific Research Fund Project of the Yunnan Provincial Department of Education","award":["2025J0183"],"award-info":[{"award-number":["2025J0183"]}]},{"name":"Yunnan Science and Technology Program","award":["202301AY070001-286"],"award-info":[{"award-number":["202301AY070001-286"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    Multidrug-resistant (MDR)\n                    <jats:italic>Chryseobacterium indologenes<\/jats:italic>\n                    is an emerging pathogen causing challenging central nervous system (CNS) infections, for which there are no standardized treatment guidelines. A systematic review of the literature indicates that such infections are extremely rare. Although trimethoprim-sulfamethoxazole (TMP-SMX) is the most frequently reported first-line therapy, its clinical efficacy is not universal, posing a significant therapeutic challenge. We present the case of a 25-year-old postpartum woman who developed MDR\n                    <jats:italic>C. indologenes<\/jats:italic>\n                    meningitis and a brain abscess after undergoing a neurosurgical procedure. The infection did not respond to initial treatment with meropenem or a subsequent course of the first-line agent TMP-SMX. Based on antimicrobial susceptibility testing, therapy was switched to rifampin monotherapy, which led to rapid clinical and microbiological recovery. The patient completed a 24-day course of rifampin and remained recurrence-free during a 20-month follow-up. This is the first report of successful rifampin monotherapy for an MDR\n                    <jats:italic>C. indologenes<\/jats:italic>\n                    CNS infection in a patient unresponsive to TMP-SMX. When considered alongside existing literature, these findings highlight the essential role of susceptibility testing and establish rifampin as an important salvage therapy for this life-threatening infection, particularly when recommended first-line treatments fail.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1701719","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:35:03Z","timestamp":1767681303000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rifampin monotherapy for multidrug-resistant Chryseobacterium indologenes meningitis unresponsive to trimethoprim-sulfamethoxazole: a case report and review of the literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Dongchuan","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuairong","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.12998\/wjcc.v11.i15.3418","article-title":"Clinical 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