{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:41:48Z","timestamp":1770748908035,"version":"3.50.0"},"reference-count":214,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>In vitro<\/jats:italic>\n                      fertilization\u2013embryo transfer (IVF-ET) is a core assisted reproductive technology (ART) for infertile couples, but poor endometrial receptivity (ER) severely impairs embryo implantation and reduces success rates, imposing significant psychological and economic burdens. Acupuncture and moxibustion have been validated to improve ER via multiple mechanisms, yet no reviews systematically summarize clinical evidence on their subtypes and underlying pathways to guide future research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to comprehensively synthesize recent advances in acupuncture and moxibustion for enhancing ER in IVF-ET patients, promoting clinical application and research awareness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted across PubMed, Web of Science, CNKI, and WanFang databases (January 2020\u2013June 2025), supplemented with seminal studies. After screening, 214 studies were included for qualitative synthesis; methodological quality was assessed using RoB 2.0 (RCTs) and NOS (non-RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acupuncture (traditional manual, electroacupuncture, and TEAS) and moxibustion (wheat, herbal cake, and warm uterus moxibustion) improve ER by regulating endometrial thickness, blood flow (e.g., reduced PI\/RI), hormone levels (E2 and P), and type A endometrium ratio. Combined therapies (e.g., warm needling + acupuncture) further enhance efficacy. Mechanisms involve modulating autophagy (AMPK\/mTOR pathway), pinopode-related molecules (LIF, integrin \u03b1v\u03b23), non-coding RNAs (miR-449a, circRNAs), and VEGF-mediated angiogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acupuncture and moxibustion are promising adjunctive therapies for ER enhancement in IVF-ET, but high-quality, standardized RCTs are needed to confirm efficacy, standardize protocols, and reduce bias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1702214","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:47:17Z","timestamp":1770706037000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of acupuncture and moxibustion therapy on endometrial receptivity of infertile women with in vitro fertilization\u2013embryo transfer: status quo and countermeasures"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiao-Zhu","family":"Guo","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]},{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Qin","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deng-Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Wuxing District People's Hospital, Huzhou","place":["Zhejiang, China"]},{"name":"First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin","place":["Heilongjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Han","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine","place":["Harbin, China"]},{"name":"The First Affiliated Hospital of Harbin University","place":["Harbin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Hua","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.molmed.2020.12.008","article-title":"Strategies to identify genetic variants causing infertility","volume":"27","author":"Ding","year":"2021","journal-title":"Trends Mol Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1093\/humrep\/dex234","article-title":"The international glossary on infertility and fertility care","volume":"32","author":"Zegers-Hochschild","year":"2017","journal-title":"Hum Reprod."},{"key":"B3","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/1471-0528.14966","article-title":"Epidemiology of infertility in China: a population-based study","volume":"125","author":"Zhou","year":"2018","journal-title":"BJOG."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1093\/humrep\/deh870","article-title":"Definition and prevalence of subfertility and infertility","volume":"20","author":"Gnoth","year":"2005","journal-title":"Hum. 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