{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T05:19:56Z","timestamp":1763011196576,"version":"3.45.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is a chronic immune-mediated disorder associated with substantial psychosocial burden. Generic dermatology instruments, such as the DLQI, may fail to capture AA-specific concerns, prompting the development of targeted questionnaires like the AA-QLI. However, existing tools show methodological limitations and inconsistent use. This study aimed to validate the Spanish Alopecia Areata\u2013Life Impact Questionnaire (SAALIQ) by assessing its reliability, validity, and responsiveness, providing a robust instrument for evaluating the quality-of-life (QoL) impact of AA in Spanish-speaking patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center cross-sectional study was conducted between June 2024 and June 2025. Adults with AA, recruited sequentially regardless of disease severity, duration, or prior treatments, were included. QoL was assessed using generic and disease-specific questionnaires, including the SAALIQ, developed in collaboration with the Alopecia Association of the Community of Madrid. Psychometric validation included assessment of internal consistency, test\u2013retest reliability, and convergent validity. Receiver-operating characteristic (ROC) analyses were performed to determine cut-off points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 85 patients with AA were included (72.94% women, 27.06% men) with a mean age of 37.55\u202fyears. The mean disease duration was 10.12\u202fyears, and the mean baseline SALT score was 36.52%. Cronbach\u2019s\n                      <jats:italic>\u03b1<\/jats:italic>\n                      ranged from 0.73 to 0.80 across emotional, functional, and social domains. Intraclass correlation coefficient (ICC) for the total score was 0.947. Convergent validity was confirmed by moderate-to-strong correlations with DLQI, Hospital Anxiety and Depression Scale (HADS-A, HADS-D), and a strong correlation with the AA-QLI (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.603;\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u202f=\u202f0.714;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001). Greater SAALIQ scores were observed in women, in patients with AA totalis (AAT) or multiple patch involvement, and in those with longer disease duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). ROC analysis identified SAALIQ cut-offs of &amp;lt;20 for absent\/mild, \u226520 for moderate, and &amp;gt;26 for severe QoL impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The SAALIQ is a disease-specific and culturally adapted tool that enables accurate measurement of the QoL impact of AA in Spanish-speaking patients. Its psychometric performance, validated cut-off points, and ability to capture domains overlooked by generic measures make it an essential resource for patient-centered care, clinical trials, and international research. Further studies are warranted to confirm the generalizability of our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1706110","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T05:16:32Z","timestamp":1763010992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychometric validation of the Spanish alopecia areata\u2013life impact questionnaire"],"prefix":"10.3389","volume":"12","author":[{"given":"Daniel","family":"Mu\u00f1oz-Barba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Garc\u00eda-Moronta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Limeres-De la Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"S\u00e1nchez-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/12034754231168839","article-title":"Alopecia Areata: an updated review for 2023","volume":"27","author":"Sibbald","year":"2023","journal-title":"J Cutan Med Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1001\/jamadermatol.2022.6085","article-title":"Prevalence and odds of depressive and anxiety disorders and symptoms in children and adults with alopecia Areata: a systematic review and Meta-analysis","volume":"159","author":"Lauron","year":"2023","journal-title":"JAMA Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s41687-020-00240-7","article-title":"\u00ab\u201cyou lose your hair, what\u2019s the big deal?\u201d I was so embarrassed, I was so self-conscious, I was so depressed:\u00bb a qualitative interview study to understand the psychosocial burden of alopecia areata","volume":"4","author":"Aldhouse","year":"2020","journal-title":"J Patient Rep Outcomes"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1111\/jdv.18733","article-title":"Prevalence and implications of type D personality in patients with alopecia areata: a marker of quality-of-life impairment and mood status disturbances, a comparative study","volume":"37","author":"S\u00e1nchez-D\u00edaz","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology life quality index (DLQI)--a simple practical measure for routine clinical use","volume":"19","author":"Finlay","year":"1994","journal-title":"Clin Exp Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/bjd.21696","article-title":"Analysis of alopecia areata surveys suggests a threshold for improved patient-reported outcomes","volume":"187","author":"Renert-Yuval","year":"2022","journal-title":"Br J Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e276","DOI":"10.1111\/j.1468-3083.2012.04629.x","article-title":"Quality of life in alopecia areata: a disease-specific questionnaire","volume":"27","author":"Fabbrocini","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1111\/jdv.17370","article-title":"Quality of life measurement in alopecia areata. 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