{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:34:59Z","timestamp":1765780499791,"version":"3.48.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    This report describes a rare case of solitary pulmonary tuberculoma in a pediatric patient. A 13-year-old male presented with a progressively enlarging solitary nodule in the left lung, identified via chest computed tomography (CT). The patient had no obvious symptoms of tuberculosis and no known history of exposure. The tuberculin skin test was negative. The imaging findings strongly resembled a peripheral pulmonary hamartoma, leading to a preliminary diagnosis of pulmonary hamartoma with plans for video-assisted thoracoscopic surgery resection. Intraoperative findings revealed extensive and dense pleural adhesions, complicating both the identification of the lesion and surgical procedures. Postoperative pathology confirmed pulmonary tuberculoma. Additional diagnostic tests, including acid-fast bacillus staining,\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    polymerase chain reaction, and T-cell immunospot test for tuberculosis infection, all returned positive results. The patient recovered without complications and received standard anti-tuberculosis therapy. No recurrence was observed during a 12-month follow-up. Therefore, in cases of solitary pulmonary nodules in children, particularly in regions with high tuberculosis prevalence, pulmonary tuberculoma should be considered, even when imaging features are consistent with pulmonary hamartoma. It is recommended that tuberculosis screening be enhanced through a combination of interferon-gamma release assay and tuberculin skin test, with needle biopsy employed when necessary to improve diagnostic accuracy and prevent misdiagnosis. Additionally, for pediatric patients with pulmonary tuberculoma, the potential impact of tuberculous pleuritis should be considered preoperatively, and anti-tuberculosis therapy may be required before surgery to reduce operative risks.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1706112","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:30:25Z","timestamp":1765780225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric solitary pulmonary tuberculoma mimicking peripheral pulmonary hamartoma with extensive pleural adhesions: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Kaiyi","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhui","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"ref1","volume-title":"Global tuberculosis report 2024","year":"2024"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.5546\/aap.2022.e218","article-title":"Pulmonary tuberculosis presenting as a lung mass in children: case report","volume":"120","author":"Fern\u00e1ndez Sard\u00e1","year":"2022","journal-title":"Arch Argent Pediatr"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s12885-023-10734-4","article-title":"Radiomics nomogram for preoperative differentiation of pulmonary mucinous adenocarcinoma from tuberculoma in solitary pulmonary solid nodules","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.2169\/internalmedicine.53.1880","article-title":"Pediatric pulmonary tuberculoma with a solid pulmonary nodule detected on chest computed tomography","volume":"53","author":"Ushiki","year":"2014","journal-title":"Intern Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jrid.2018.08.002","article-title":"Large pulmonary solitary mass caused by Mycobacterium tuberculosis mimicking a malignant tumor in a child","volume":"5","author":"Chen","year":"2018","journal-title":"Radiol Infect. Dis"},{"key":"ref6","first-page":"1588","article-title":"Dynamic and contrast enhanced CT imaging of lung carcinoma, pulmonary tuberculoma, and inflammatory pseudotumor","volume":"21","author":"Li","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.5152\/eurasianjmed.2022.21150","article-title":"Pulmonary hamartomas: a single-center analysis of 59 cases","volume":"54","author":"Ulas","year":"2022","journal-title":"Eurasian J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"607","DOI":"10.47162\/RJME.63.4.02","article-title":"The clinicopathological challenges of symptomatic and incidental pulmonary hamartomas diagnosis","volume":"63","author":"Grigora\u015f","year":"2023","journal-title":"Romanian J Morphol Embryol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1586\/14787210.3.6.981","article-title":"Diagnosis of latent Mycobacterium tuberculosis infection: is the demise of the mantoux test imminent?","volume":"3","author":"Rothel","year":"2005","journal-title":"Expert Rev Anti-Infect Ther"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3390\/diagnostics12020453","article-title":"Diagnostic value of interferon-gamma release assays for tuberculosis in the immunocompromised population","volume":"12","author":"Yang","year":"2022","journal-title":"Diagnostics"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.20471\/acc.2023.62.03.15","article-title":"The role of interferon-gamma release assays in diagnosis of latent tuberculosis infection in children","volume":"62","author":"\u0160egovi\u0107","year":"2023","journal-title":"Acta Clin Croat"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.15562\/ism.v14i3.1900","article-title":"Pulmonary tuberculoma, to resect or not to resect: a systematic review","volume":"14","author":"Rahayu","year":"2023","journal-title":"Intisari Sains Medis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.21037\/jtd.2017.08.44","article-title":"Recent advances in the management of pulmonary tuberculoma with focus on the use of tubeless video-assisted thoracoscopic surgery","volume":"9","author":"Xia","year":"2017","journal-title":"J Thorac Dis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1631\/jzus.B0820368","article-title":"Value of video-assisted thoracoscopic surgery in the diagnosis and treatment of pulmonary tuberculoma: 53 cases analysis and review of literature","volume":"10","author":"Hsu","year":"2009","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.clim.2005.03.015","article-title":"Cytokines and fibrinolytic enzymes in tuberculous and parapneumonic effusions","volume":"116","author":"Lin","year":"2005","journal-title":"Clin Immunol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1706112\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:30:26Z","timestamp":1765780226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1706112\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":15,"alternative-id":["10.3389\/fmed.2025.1706112"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1706112","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"article-number":"1706112"}}