{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:34:58Z","timestamp":1767591298377,"version":"3.48.0"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Intussusception secondary to gastrointestinal diffuse large B-cell lymphoma (DLBCL) is exceedingly rare in adults. We present a case of a 23-year-old male admitted with abdominal pain as the primary symptom. Computed tomography (CT) revealed an ileocolic intussusception involving the ascending and transverse colon, demonstrating a characteristic \u201ctarget.\u201d Conservative treatment (including air enema) was ineffective, and the patient finally received surgical treatment. The resected lesion was pathologically confirmed as DLBCL. The patient received postoperative chemotherapy with the R-CHOP regimen. At the 5-month follow-up, no complications or evidence of lymph node involvement elsewhere was observed. Adult intussusception patients should be highly alert to the possibility of malignant tumors, especially lymphoma. Early diagnosis and standardized comprehensive treatment are critical for improving long-term prognosis.<\/jats:p>","DOI":"10.3389\/fmed.2025.1717969","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:30:17Z","timestamp":1767591017000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse large B-cell lymphoma with intussusception in adults: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Kang","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qicui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3748\/wjg.15.407","article-title":"Intussusception of the bowel in adults: a review.","volume":"15","author":"Marinis","year":"2009","journal-title":"World J Gastroenterol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"393","DOI":"10.5455\/medarh.2020.74.393-395","article-title":"Pedunculated lipoma of the caecum causing colocolic intussusception in an adult.","volume":"74","author":"Vagholkar","year":"2020","journal-title":"Med Arch."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.3748\/wjg.v13.i26.3641","article-title":"Lipoma induced jejunojejunal intussusception.","volume":"13","author":"Manouras","year":"2007","journal-title":"World J Gastroenterol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.radcr.2020.07.008","article-title":"Ileo-caecal intussusception secondary to lipoma in an adult: a rare cause for intestinal obstruction.","volume":"15","author":"Abdulla","year":"2020","journal-title":"Radiol Case Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4274\/balkanmedj.galenos.2020.2020.4.223","article-title":"A case of intussusception caused by diffuse large B cell lymphoma in ileocecal region.","volume":"38","author":"Zhou","year":"2021","journal-title":"Balkan Med J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s10151-019-01980-5","article-title":"Wexner SD Adult intussusception: a systematic review and meta-analysis.","volume":"23","author":"Hong","year":"2019","journal-title":"Tech Coloproctol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"106748","DOI":"10.1016\/j.ijscr.2021.106748","article-title":"A rare case of primary non-metastatic Non-Hodgkin\u2019s diffuse large B-cell lymphoma in the ileum in a 19-year-old male manifested as intestinal obstruction- A case report.","volume":"90","author":"Albrijawy","year":"2022","journal-title":"Int J Surg Case Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.4081\/cp.2020.1292","article-title":"A rare case report of large B cell lymphoma in adult presentation as intussusception.","volume":"10","author":"Wagh","year":"2020","journal-title":"Clin Pract."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.21037\/atm-21-4761","article-title":"Development and validation of prognostic scoring in primary intestinal diffuse large B-cell lymphoma: a single-institution study of 184 patients.","volume":"9","author":"Fan","year":"2021","journal-title":"Ann Transl Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.annepidem.2008.10.004","article-title":"The epidemiology and pathogenesis of neoplasia in the small intestine.","volume":"19","author":"Schottenfeld","year":"2009","journal-title":"Ann Epidemiol."},{"key":"B11","first-page":"506","article-title":"Paul Barbette, M.D.: a seventeenth-century Amsterdam author of best-selling textbooks.","volume":"59","author":"de Moulin","year":"1985","journal-title":"Bull Hist Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"8449","DOI":"10.3748\/wjg.v19.i45.8449","article-title":"Ileo-ileal intussusception caused by diffuse large B-cell lymphoma of the ileum.","volume":"19","author":"Xu","year":"2013","journal-title":"World J Gastroenterol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"6265182","DOI":"10.1155\/2018\/6265182","article-title":"Minimally invasive treatment of sporadic Burkitt\u2019s lymphoma causing ileocaecal invagination.","volume":"2018","author":"Panaccio","year":"2018","journal-title":"Case Rep Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"W9","DOI":"10.2214\/ajr.12.8492","article-title":"Primary malignant diseases of the small intestine.","volume":"201","author":"McLaughlin","year":"2013","journal-title":"AJR Am J Roentgenol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/0002-9610(76)90196-3","article-title":"Adult intussusception; case report of recurrent intussusception and review of the literature.","volume":"131","author":"Felix","year":"1976","journal-title":"Am J Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"244","DOI":"10.4174\/astr.2014.86.5.244","article-title":"Adult intussusceptions: preoperative predictive factors for malignant lead point.","volume":"86","author":"Kim","year":"2014","journal-title":"Ann Surg Treat Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1259\/0007-1285-45-529-1","article-title":"The mechanism of intussusception: a theoretical analysis of the phenomenon.","volume":"45","author":"Reymond","year":"1972","journal-title":"Br J Radiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e68482","DOI":"10.1371\/journal.pone.0068482","article-title":"Childhood intussusception: a literature review.","volume":"8","author":"Jiang","year":"2013","journal-title":"PLoS One."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5745","DOI":"10.3748\/wjg.v18.i40.5745","article-title":"Intussusception due to inflammatory fibroid polyp: a case report and comprehensive literature review.","volume":"18","author":"Akbulut","year":"2012","journal-title":"World J Gastroenterol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12887-023-03961-y","article-title":"Epidemiology, clinical characteristics, and treatment of children with acute intussusception: a case series.","volume":"23","author":"Li","year":"2023","journal-title":"BMC Pediatr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"206","DOI":"10.4103\/1319-3767.43278","article-title":"Jejunal lipoma with intermittent intussusception revealed by partial obstructive syndrome.","volume":"14","author":"Jai","year":"2008","journal-title":"Saudi J Gastroenterol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1055\/s-0036-1593429","article-title":"Intestinal intussusception: etiology, diagnosis, and treatment.","volume":"30","author":"Marsicovetere","year":"2017","journal-title":"Clin Colon Rectal Surg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e25368","DOI":"10.7759\/cureus.25368","article-title":"Intestinal intussusception: a shocking diagnosis.","volume":"14","author":"Morais","year":"2022","journal-title":"Cureus."},{"key":"B24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ijscr.2014.07.009","article-title":"Surgically inverting an incidentally detected Meckel\u2019s diverticulum - Wrong method.","author":"Shah","year":"2015","journal-title":"Int J Surg Case Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/s1072-7515(98)00331-7","article-title":"Intussusception in adults: institutional review.","volume":"188","author":"Eisen","year":"1999","journal-title":"J Am Coll Surg."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e000320","DOI":"10.1136\/bmjgast-2019-000320","article-title":"Gastrointestinal lymphoma: the new mimic.","volume":"6","author":"Shirwaikar Thomas","year":"2019","journal-title":"BMJ Open Gastroenterol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.3748\/wjg.v17.i41.4625","article-title":"Primary intestinal non-Hodgkin\u2019s lymphoma: a clinicopathologic analysis of 81 patients.","volume":"17","author":"Wang","year":"2011","journal-title":"World J Gastroenterol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.5858\/arpa.2011-0145-RA","article-title":"Lymphoproliferative disorders of the gastrointestinal tract: a review and pragmatic guide to diagnosis.","volume":"135","author":"Burke","year":"2011","journal-title":"Arch Pathol Lab Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"909","DOI":"10.5152\/tjg.2022.211003","article-title":"Effect of clinical, endoscopic, radiological findings, and complications on survival in patients with primary gastrointestinal lymphoma.","volume":"33","author":"Erkut","year":"2022","journal-title":"Turk J Gastroenterol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.3109\/10428194.2012.695780","article-title":"Diagnosis and management of rare gastrointestinal lymphomas.","volume":"53","author":"Hawkes","year":"2012","journal-title":"Leuk Lymphoma."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00277-004-0939-7","article-title":"Epidemiology of non-Hodgkin\u2019s lymphoma (NHL): trends, geographic distribution, and etiology.","volume":"84","author":"M\u00fcller","year":"2005","journal-title":"Ann Hematol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1038\/modpathol.2012.178","article-title":"Aggressive B-cell lymphomas: how many categories do we need?","volume":"26","author":"Said","year":"2013","journal-title":"Mod Pathol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2324709616642592","DOI":"10.1177\/2324709616642592","article-title":"Cutaneous presentation of double hit lymphoma: a case report with review of the literature.","volume":"4","author":"Khelfa","year":"2016","journal-title":"J Investig Med High Impact Case Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"13520","DOI":"10.1073\/pnas.0804295105","article-title":"Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.","volume":"105","author":"Lenz","year":"2008","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.3390\/cancers12123553","article-title":"Molecular genetics of relapsed diffuse large B-cell lymphoma: insight into mechanisms of therapy resistance.","volume":"12","author":"Berendsen","year":"2020","journal-title":"Cancers."},{"key":"B36","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/15384047.2018.1449609","article-title":"Lenalidomide combined with R-GDP in a patient with refractory CD5-positive diffuse large B-cell lymphoma: a promising response and review.","volume":"19","author":"Zhang","year":"2018","journal-title":"Cancer Biol Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e00131","DOI":"10.14309\/crj.0000000000000131","article-title":"Recurrent gastrointestinal near-tetraploid diffuse large B-cell lymphoma causing intussusception and ileal ulceration.","volume":"6","author":"Mathews","year":"2019","journal-title":"ACG Case Rep J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1097\/ms9.0000000000000515","article-title":"Incidental finding of multiple diffuse large B-cell lymphomas masquerading as jejunojejunal intussusception with unexplained pleural effusion: a case report.","volume":"85","author":"Liu","year":"2023","journal-title":"Ann Med Surg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.55729\/2000-9666.1234","article-title":"Adult ileoileal intussusception caused by diffuse large B-cell Lymphoma(\u22c6).","volume":"13","author":"Louis-Jean","year":"2023","journal-title":"J Community Hosp Intern Med Perspect."},{"key":"B40","doi-asserted-by":"publisher","first-page":"110481","DOI":"10.1016\/j.ijscr.2024.110481","article-title":"A case report: Diagnosis of early stage ascending colon adenocarcinoma due to concomitant lymphoma presented by ileocaecal intussusception and literature review.","volume":"125","author":"Jin","year":"2024","journal-title":"Int J Surg Case Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e83072","DOI":"10.7759\/cureus.83072","article-title":"HIV intussusception, and a hidden malignancy masquerading abdominal tuberculosis: diffuse large B-Cell lymphoma unveiled.","volume":"17","author":"Singh","year":"2025","journal-title":"Cureus."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e9046","DOI":"10.1002\/ccr3.9046","article-title":"Diffuse large B-cell lymphoma-induced intussusception: a case report and literature review.","volume":"12","author":"Chang","year":"2024","journal-title":"Clin Case Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1561289","DOI":"10.3389\/fmed.2025.1561289","article-title":"Intussusception in an adult with a history of rectal cancer: a case report.","volume":"12","author":"Liu","year":"2025","journal-title":"Front Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1148\/rg.263055100","article-title":"Adult intestinal intussusception: CT appearances and identification of a causative lead point.","volume":"26","author":"Kim","year":"2006","journal-title":"Radiographics."},{"key":"B45","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1477-7819-7-60","article-title":"Mantle cell lymphoma of the gastrointestinal tract presenting with multiple intussusceptions\u2013case report and review of literature.","volume":"7","author":"Kella","year":"2009","journal-title":"World J Surg Oncol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ijscr.2020.12.061","article-title":"A case of multiple recurrent intussusceptions due to multiple lymphomatous polyposis associated with diffuse large B-cell lymphoma of gastrointestinal tract in a 15-year-old child: a rare case report.","volume":"79","author":"Sharma","year":"2021","journal-title":"Int J Surg Case Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ijscr.2016.07.019","article-title":"Adult colo-colonic intussusception caused by congenital bands: A case report and literature review.","volume":"26","author":"Wang","year":"2016","journal-title":"Int J Surg Case Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"109841","DOI":"10.1016\/j.ijscr.2024.109841","article-title":"Colocolic intussusception as a rare cause of intestinal obstruction in a preschool child: a case report.","volume":"120","author":"Rwomurushaka","year":"2024","journal-title":"Int J Surg Case Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1097\/ms9.0000000000000458","article-title":"Small bowel intussusception in an adult secondary to gastrointestinal stromal tumor: a rare case report.","volume":"85","author":"Basukala","year":"2023","journal-title":"Ann Med Surg."},{"key":"B50","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ijscr.2020.04.010","article-title":"Transient jejuno-jejunal intussusception in an anabolic steroid user-A case report.","volume":"70","author":"De Robles","year":"2020","journal-title":"Int J Surg Case Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1182\/blood-2010-06-288480","article-title":"Comparison of treatment strategies for patients with intestinal diffuse large B-cell lymphoma: surgical resection followed by chemotherapy versus chemotherapy alone.","volume":"117","author":"Kim","year":"2011","journal-title":"Blood."},{"key":"B52","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bpg.2009.12.002","article-title":"Role of radiotherapy in the treatment of lymphomas of the gastrointestinal tract.","volume":"24","author":"Aleman","year":"2010","journal-title":"Best Pract Res Clin Gastroenterol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1200\/jco.2011.41.0985","article-title":"Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.","volume":"30","author":"Johnson","year":"2012","journal-title":"J Clin Oncol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1717969\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:30:18Z","timestamp":1767591018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1717969\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":53,"alternative-id":["10.3389\/fmed.2025.1717969"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1717969","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"article-number":"1717969"}}