{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:28:57Z","timestamp":1767677337567,"version":"3.48.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder linked to obesity, metabolic syndrome, and systemic inflammation. Myosteatosis is associated with adverse metabolic outcomes, but its relationship with HS has not been explored. The present study aimed to compare muscle and fat composition, focusing on myosteatosis and sarcopenia, between HS patients and controls, and to assess associations with clinical and metabolic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 61 HS patients and 59 age- and sex-matched controls with non-contrast thoracoabdominal computed tomography (CT) scans. Muscle and fat compartments at the 12th thoracic vertebra were quantified. Sarcopenia and myosteatosis were defined using established CT-based criteria. Clinical and laboratory data, including fasting glucose, lipid profile, and comorbidities, were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to logistic regression analyses, myosteatosis showed significant independent associations with HS and with a history of biologic therapy (HS: OR\u202f=\u202f3.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004; biologic therapy: OR\u202f=\u202f0.085,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.014). HS patients exhibited significantly higher intermuscular adipose tissue (IMAT) (1574.8\u202f\u00b1\u202f1243.8\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 1112.7\u202f\u00b1\u202f822.5\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.029), low attenuation muscle area (LAMA) (5013.1\u202f\u00b1\u202f1999.8\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      vs. 2996.4\u202f\u00b1\u202f1220.7\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), and LAMA\/BMI indices (low attenuation muscle area normalized to BMI), alongside lower normal attenuation muscle area (NAMA)\/BMI indices (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), indicating increased myosteatosis and reduced muscle quality. Sarcopenia prevalence was similar. Hypertensive patients had lower NAMA\/TAMA (total abdominal muscle area) and higher LAMA\/BMI indices. Disease severity negatively correlated with HDL cholesterol (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). BMI, TAMA, subcutaneous, and visceral adipose tissue were similar between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that HS is independently associated with myosteatosis, but not with sarcopenia. A history of long-term biologic therapy was also strongly and independently linked to myosteatosis, suggesting a previously underrecognized interaction between systemic inflammation, treatment exposure, and muscle quality. Muscle fat infiltration may represent an underrecognized metabolic risk factor in HS, highlighting the need for further prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1719183","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:18:22Z","timestamp":1767676702000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myosteatosis as a metabolic risk in hidradenitis suppurativa: a CT-based study"],"prefix":"10.3389","volume":"12","author":[{"given":"Didem Didar","family":"Balci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayg\u00fcn","family":"Talibova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caner","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u011f\u0131z","family":"\u00dcst\u00fcnda\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raif Can","family":"Yarol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melis","family":"G\u00f6n\u00fclal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Arg\u00fcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melih","family":"\u00d6zcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bur\u00e7in Kibar","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl","family":"\u00c7olako\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli S\u00fcha","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Balci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.jaad.2019.08.090","article-title":"Hidradenitis suppurativa: epidemiology, clinical presentation, and pathogenesis","volume":"82","author":"Goldburg","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1001\/jamadermatol.2021.1677","article-title":"Prevalence of hidradenitis suppurativa: a systematic review and meta-regression analysis","volume":"157","author":"Jfri","year":"2021","journal-title":"JAMA Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.jaad.2014.09.012","article-title":"Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: a chart-verified case-control analysis","volume":"71","author":"Shlyankevich","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1111\/exd.14214","article-title":"What causes hidradenitis suppurativa? \u2014 15 years after","volume":"29","author":"Zouboulis","year":"2020","journal-title":"Exp Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e31810","DOI":"10.1371\/journal.pone.0031810","article-title":"Increased prevalence of metabolic syndrome in patients with acne inversa","volume":"7","author":"Sabat","year":"2012","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1111\/bjd.14024","article-title":"Cardiovascular disease risk factors in patients with hidradenitis suppurativa: a systematic review and meta-analysis of observational studies","volume":"173","author":"Tzellos","year":"2015","journal-title":"Br J Dermatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2760","DOI":"10.3390\/jcm14082760","article-title":"The role of sex in body composition differences in hidradenitis suppurativa: insights from bioelectrical impedance analysis","volume":"14","author":"Pi\u0119towska-Marczak","year":"2025","journal-title":"J Clin Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7937","DOI":"10.21037\/qims-24-365","article-title":"Myosteatosis: diagnostic significance and assessment by imaging approaches","volume":"14","author":"Garcia-Diez","year":"2024","journal-title":"Quant Imaging Med Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis. Report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"482","DOI":"10.4093\/dmj.2020.0277","article-title":"Computed tomography-derived myosteatosis and metabolic disorders","volume":"45","author":"Miljkovic","year":"2021","journal-title":"Diabetes Metab J"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1093\/gerona\/glz034","article-title":"Approaches to assessment of muscle mass and myosteatosis on computed tomography: a systematic review","volume":"74","author":"Amini","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13244-021-01106-2","article-title":"Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults","volume":"12","author":"Tan","year":"2021","journal-title":"Insights Imaging"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/jcsm.12189","article-title":"Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis","volume":"8","author":"Tournadre","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"7635","DOI":"10.3390\/ijms26157635","article-title":"Longitudinal assessment of body composition and inflammatory status in rheumatoid arthritis during TNF inhibitor treatment: a pilot study","volume":"26","author":"Mena-V\u00e1zquez","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1111\/j.1365-2133.2011.10254.x","article-title":"Elevated levels of tumour necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b2 and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-\u03b1 and IL-1\u03b2","volume":"164","author":"van der Zee","year":"2011","journal-title":"Br J Dermatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1016\/j.jid.2017.05.033","article-title":"Hidradenitis suppurativa is characterized by dysregulation of the Th17:Treg cell axis, which is corrected by anti-TNF therapy","volume":"137","author":"Moran","year":"2017","journal-title":"J Invest Dermatol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.2147\/JIR.S366204","article-title":"Skeletal myosteatosis is associated with systemic inflammation and a loss of muscle bioenergetics in stable COPD","volume":"15","author":"Persson","year":"2022","journal-title":"J Inflamm Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.maturitas.2016.11.006","article-title":"Inflammation and sarcopenia: a systematic review and meta-analysis","volume":"96","author":"Bano","year":"2017","journal-title":"Maturitas"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"754932","DOI":"10.3389\/fmed.2021.754932","article-title":"Psoriasis is associated with myosteatosis but not sarcopenia: a case-control study","volume":"8","author":"Chen","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"594735","DOI":"10.3389\/fimmu.2020.594735","article-title":"The IL-23\/IL-17 pathway in inflammatory skin diseases: from bench to bedside","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1002\/oby.23190","article-title":"Comparison of muscle mass and quality between metabolically healthy and unhealthy phenotypes","volume":"29","author":"Kim","year":"2021","journal-title":"Obesity (Silver Spring)"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1440-1797.2009.01261.x","article-title":"Investigation of skeletal muscle quantity and quality in end-stage renal disease","volume":"15","author":"Cheema","year":"2010","journal-title":"Nephrology (Carlton)"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/s41440-022-01157-y","article-title":"Association between hypertension and myosteatosis evaluated by abdominal computed tomography","volume":"46","author":"Jung","year":"2023","journal-title":"Hypertens Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.3390\/antiox14081014","article-title":"Oxidative stress, high density lipoproteins and hidradenitis suppurativa: a prospective study","volume":"14","author":"Molinelli","year":"2025","journal-title":"Antioxidants"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1719183\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:18:22Z","timestamp":1767676702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1719183\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":24,"alternative-id":["10.3389\/fmed.2025.1719183"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1719183","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"article-number":"1719183"}}