{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:48:25Z","timestamp":1780098505492,"version":"3.54.0"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    <jats:italic>Mycobacterium chelonae<\/jats:italic>\n                    is a rapidly growing non-tuberculous mycobacterium (NTM) that causes skin and soft tissue infections, particularly in immunocompromised patients. We present the case of a 51-year-old woman receiving eculizumab therapy after kidney transplantation, who developed painful nodules and ulcers on the lower leg. Standard laboratory and imaging findings were unremarkable. Initial cultures were negative, but biopsy and subsequent wound cultures identified\n                    <jats:italic>M. chelonae<\/jats:italic>\n                    . Repeat testing confirmed the pathogen. The patient was successfully treated with a 12-month course of combination antibiotics, including clarithromycin, linezolid, and doxycycline, along with intralesional gentamicin. A follow-up biopsy showed dermal fibrosis without microorganisms. This case highlights the diagnostic challenges of\n                    <jats:italic>M. chelonae<\/jats:italic>\n                    in transplant recipients and emphasizes the importance of molecular diagnostics and tailored therapy. To the best of our knowledge, this is the first reported case of\n                    <jats:italic>M. chelonae<\/jats:italic>\n                    infection in a kidney transplant recipient receiving eculizumab as part of her post-transplant management.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2025.1728249","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:15:18Z","timestamp":1768205718000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Cutaneous Mycobacterium chelonae infection in a kidney transplant recipient with long-term immunosuppression and eculizumab therapy"],"prefix":"10.3389","volume":"12","author":[{"given":"Diana","family":"Sukackiene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deimante","family":"Satkauskaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugne","family":"Sleivyte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturas","family":"Vinikovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gintare","family":"Ulianskaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justinas","family":"Pamedys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadas","family":"Raudonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Miglinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mayocp.2012.06.029","article-title":"Increased incidence of cutaneous nontuberculous mycobacterial infection, 1980 to 2009: a population-based study. Mayo Clinic proceedings Mayo","volume":"88","author":"Wentworth","year":"2012","journal-title":"Clinic"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0278-2316(89)90038-8","article-title":"Mycobacterium chelonae infection","volume":"8","author":"Akram","year":"2023","journal-title":"Infect Dis Newsl"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jctube.2016.04.001","article-title":"Non-tuberculous mycobacterial infections in solid organ transplant recipients: an update","volume":"4","author":"Abad","year":"2016","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4103\/ijot.ijot_74_24","article-title":"Rare mycobacterial infections in kidney transplant recipients \u2013 case reports","volume":"19","author":"Rajesh","year":"2025","journal-title":"Indian J Transplantation"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/23744235.2017.1411604","article-title":"Nontuberculous mycobacterium infection in renal transplant recipients: a systematic review","volume":"50","author":"Song","year":"2018","journal-title":"Infect Dis"},{"key":"ref6","first-page":"E6","article-title":"Disseminated cutaneous infection with Mycobacterium chelonae in a renal transplant recipient","volume":"96","author":"Chatzikokkinou","year":"2015","journal-title":"Cutis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/QCO.0000000000000279","article-title":"Infections associated with the use of eculizumab: recommendations for prevention and prophylaxis","volume":"29","author":"Benamu","year":"2016","journal-title":"Curr Opin Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/bjh.15790","article-title":"Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis","volume":"185","author":"Soci\u00e9","year":"2019","journal-title":"Br J Haematol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/cid\/ciaa1125","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"71","author":"Daley","year":"2020","journal-title":"Clin Infect Dis"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1728249\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:15:22Z","timestamp":1768205722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1728249\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":9,"alternative-id":["10.3389\/fmed.2025.1728249"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1728249","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"article-number":"1728249"}}