{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T06:33:18Z","timestamp":1767335598910,"version":"3.48.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to report a case of vitrectomy with amniotic membrane transplantation (AMT) for a macular choroidal coloboma (CC) associated with a macular hole (MH) and posterior scleral staphyloma (PSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 54-year-old woman presented with a 10-day history of decreased vision and metamorphopsia in her right eye. Other than bilateral cataracts, no other ocular abnormalities were found. The best-corrected visual acuity (BCVA) was 0.05 in the right eye and 0.5 in the left eye. Scanning laser ophthalmoscopy (SLO) revealed an atrophic-like lesion and an MH in the macular area. Optical coherence tomography (OCT) revealed a macular CC with a full-thickness MH and PSS. Due to the large size of the MH(1238\u202f\u00d7\u202f976\u202f\u03bcm) and significant ocular symptoms, the patient underwent vitrectomy with internal limiting membrane (ILM) peeling, AMT, and silicone oil tamponade (SOT). At the 3-month follow-up, the amniotic membrane (AM) was functioning, but the condition had not yet stabilized. During the subsequent silicone oil removal (SOR) procedure, a second AMT was performed, followed by an intravitreal injection of C3F8 gas. At 9\u202fmonths after SOR, OCT demonstrated firm adhesion between the AM, the edges of the MH, and the sclera. The MH showed signs of stability, and the cavity formed by the CC and PSS had decreased in size. In parallel with the anatomical improvement, the patient\u2019s visual quality improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report a rare surgical case of a macular CC with an MH and PSS. Surgery resulted in improvements in both anatomic architecture and visual quality. This case expands our understanding of the pathogenesis and management of this uncommon disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1731661","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T06:28:37Z","timestamp":1767335317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitrectomy with amniotic membrane transplantation for macular choroidal coloboma with macular hole and posterior scleral staphyloma: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Jie","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanjun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.oret.2019.08.010","article-title":"Swept-source OCT analysis of the margin of choroidal coloboma: new insights","volume":"4","author":"Jain","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1038\/s41433-021-01501-5","article-title":"Ocular coloboma-a comprehensive review for the clinician","volume":"35","author":"Lingam","year":"2021","journal-title":"Eye (Lond)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4103\/tjo.tjo_26_20","article-title":"Current management strategies for atypical macular holes","volume":"11","author":"Marlow","year":"2020","journal-title":"Taiwan J Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/jpm13010075","article-title":"Trends and hotspots concerning macular hole between 2002 and 2021: a 20-year bibliometric study","volume":"13","author":"Shu","year":"2022","journal-title":"J Pers Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.preteyeres.2018.12.001","article-title":"Posterior staphyloma in pathologic myopia","volume":"70","author":"Ohno-Matsui","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.preteyeres.2018.10.005","article-title":"Myopic maculopathy: current status and proposal for a new classification and grading system (ATN)","volume":"69","author":"Ruiz-Medrano","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.oret.2020.10.012","article-title":"Structure of the retinal margin and presumed mechanism of retinal detachment in choroidal coloboma","volume":"5","author":"Tanaka","year":"2021","journal-title":"Opthalmol Retina"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1080\/02713683.2020.1853779","article-title":"A systematic review of the clinical manifestations and diagnostic methods for macular coloboma","volume":"46","author":"Hou","year":"2021","journal-title":"Curr Eye Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"699","DOI":"10.4103\/ijo.IJO_729_18","article-title":"A rare case of bilateral choroidal coloboma within deep posterior staphyloma associated with macular hole retinal detachment","volume":"67","author":"Venkatesh","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40942-022-00439-4","article-title":"Surgical classification for large macular hole: based on different surgical techniques results: the CLOSE study group","volume":"9","author":"Rezende","year":"2023","journal-title":"Int J Retina Vitreous"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Human amniotic membrane graft for refractory macular hole: A single-arm meta-analysis and systematic review\n          \n          276\n          286\n          \n            \n              Zhang\n              H\n            \n            \n              Li\n              Y\n            \n            \n              Chen\n              G\n            \n            \n              Han\n              F\n            \n            \n              Jiang\n              W\n            \n          \n          10.1016\/j.jfo.2022.07.001\n          J Fr Ophtalmol.\n          46\n          2023","DOI":"10.1016\/j.jfo.2022.07.001"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1731661\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T06:28:38Z","timestamp":1767335318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2025.1731661\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":11,"alternative-id":["10.3389\/fmed.2025.1731661"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2025.1731661","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,2]]},"article-number":"1731661"}}