{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:31:06Z","timestamp":1780050666681,"version":"3.53.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibromyalgia (FM) is a chronic disorder characterised by widespread pain, central sensitisation, and significant psychosocial burden. Patients often present impaired functional capacity, heightened pain perception, and high rates of anxiety and depression. However, the interplay among physical function, psychological distress, and body composition remains insufficiently clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 80 women with clinically diagnosed FM, aged 18\u201375\u202fyears, recruited from the Afinsyfacro Association (Madrid, Spain). Assessments comprised sociodemographic and clinical variables, functional tests [5-Sit-to-Stand test (5-STST), handgrip strength (HGS), Timed Up and Go (TUG), and 4-m gait speed], algometry, bioimpedance, and validated questionnaires (FIQ, HADS, PSQI, VAS). Correlations between pain, fibromyalgia impact, psychological symptoms, physical performance, and body composition were analysed using Pearson\u2019s or Spearman\u2019s coefficients, as appropriate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants reported severe pain (VAS\u202f=\u202f7.03\u202f\u00b1\u202f1.94) and a high disease impact (FIQ\u202f=\u202f65.27\u202f\u00b1\u202f16.07). The scores obtained on the HADS-A and HADS-D questionnaires were 12.65\u202f\u00b1\u202f4.56 and 9.93\u202f\u00b1\u202f4.56, respectively. Moderate correlations were observed between depression and both the 5-STST (r\u202f=\u202f0.325,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01) and TUG (r\u202f=\u202f0.346,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01), while fibromyalgia impact correlated with all functional measures except HGS. Pain correlated with both anxiety (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.477,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01) and depression (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f0.430,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.01). No significant associations were found between body composition variables and FM impact or pain. The overall fit was significant,\n                      <jats:italic>F<\/jats:italic>\n                      (4, 63)\u202f=\u202f23.169,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001. Pain (VAS) and depressive symptoms (HADS-depression) contributed independently to higher FIQ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Effective management of FM requires a multidisciplinary approach integrating therapeutic exercise, pain management, psychological support, and strategies to optimise body composition and overall health. This holistic perspective may reduce symptom burden and improve quality of life in affected individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2025.1745951","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:12:38Z","timestamp":1768205558000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between pain, functionality, and body composition in patients with fibromyalgia: cross-sectional study"],"prefix":"10.3389","volume":"12","author":[{"given":"Edurne","family":"\u00dabeda-D\u2019Ocasar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Mayoral-Gonzalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Pedauy\u00e9-Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Daguerre-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ojedo-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Fern\u00e1ndez-Ace\u00f1ero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Herv\u00e1s-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Cimadevilla-Fern\u00e1ndez-Pola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"A6","DOI":"10.1176\/appi.neuropsych.19050107","article-title":"Fibromyalgia: centralized pain processing and neuroimaging","volume":"31","author":"Richard","year":"2019","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/B978-0-7020-4086-3.00033-3","article-title":"Fibromyalgia","volume":"119","author":"Sumpton","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"ref3","first-page":"89","article-title":"Prevalencia de s\u00edntomas neurol\u00f3gicos asociados a la fibromialgia","volume-title":"Rev Soc Esp Dolor","author":"G\u00f3mez-Arg\u00fcelles","year":"2009"},{"key":"ref4","first-page":"430","article-title":"Fibromialgia: Diagn\u00f3stico Y Tratamiento. El Estado de la cuesti\u00f3n","volume":"11","author":"Villanueva","year":"2004","journal-title":"Rev Soc Esp Dolor"},{"key":"ref5","first-page":"1","article-title":"Unraveling the complex web of fibromyalgia: a narrative review","volume":"60","author":"Al Sharie","year":"2024","journal-title":"Medicina (Lithuania)"},{"key":"ref6","first-page":"S3","article-title":"Fibromyalgia: an overview","volume":"122","author":"Clauw","year":"2009","journal-title":"Am J Med Elsevier Inc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.3390\/biomedicines11123321","article-title":"Skin bioimpedance analysis to determine cellular integrity by phase angle in women with fibromyalgia: a cross-sectional study","volume":"11","author":"Vicente-Campos","year":"2023","journal-title":"Biomedicine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neuroscience.2016.06.006","article-title":"Neurobiology of fibromyalgia and chronic widespread 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function and physical performance in daily clinical practice: a position paper endorsed by the European Society for Clinical and Economic Aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)","volume-title":"Calcif Tissue Int Springer US","author":"Beaudart","year":"2019"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1519\/JSC.0b013e318234e59f","article-title":"Test-retest reliability of the five-repetition sit-to-stand test: a systematic review of the literature involving adults","volume":"25","author":"Bohannon","year":"2011","journal-title":"J Strength Cond Res"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1055\/s-0034-1390497","article-title":"Reliability and feasibility of physical fitness tests in female fibromyalgia patients","volume":"36","author":"Carbonell-Baeza","year":"2015","journal-title":"Int J Sports 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fibromyalgia impact questionnaire: development and validation","volume":"18","author":"Burckhardt","year":"1991","journal-title":"J Rheumatol"},{"key":"ref22","first-page":"507","article-title":"Validaci\u00f3n de la versi\u00f3n espa\u00f1ola del Fibromyalgia Impact Questionnaire","volume":"31","author":"Monterde","year":"2004","journal-title":"Rev Esp Reumatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.23938\/ASSN.0390","article-title":"Validation of an instrument for measuring chronic pain in nursing homes","volume":"42","author":"Ubillos-Landa","year":"2019","journal-title":"An Sist Sanit Navar"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph18041461","article-title":"Pain intensity and sensory perception of tender points in female patients with fibromyalgia: a pilot study","volume":"18","author":"\u00dabeda-D\u2019ocasar","year":"2021","journal-title":"Int J Environ Res Public 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fibromyalgia","volume":"2022","author":"Montoro","year":"2022","journal-title":"Behav Neurol"},{"key":"ref28","first-page":"E30868","article-title":"The relationship between fibromyalgia and depression, anxiety, anxiety sensitivity, fear avoidance beliefs, and quality of life in female patients","volume":"101","author":"Cetingok","year":"2022","journal-title":"Medicine (United States)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"101226","DOI":"10.1016\/j.bjpt.2025.101226","article-title":"The most effective therapeutic exercises for pain intensity in women with fibromyalgia: a systematic review and network meta-analysis","volume":"29","author":"Rodr\u00edguez-Dom\u00ednguez","year":"2025","journal-title":"Braz J Phys Ther"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1093\/schbul\/sbw029","article-title":"Chronic peripheral inflammation is associated with cognitive impairment in schizophrenia: results from the multicentric FACE-SZ 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Community Health"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.51230\/ri.v18i1.97","article-title":"Efectividad y beneficios del ejercicio f\u00edsico en pacientes con fibromialgia: una revisi\u00f3n bibliogr\u00e1fica","volume":"18","author":"Toledo","year":"2024","journal-title":"Rehabil integral"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/j.1526-4637.2011.01239.x","article-title":"Pain and functional capacity in female fibromyalgia patients","volume":"12","author":"Carbonell-baeza","year":"2011","journal-title":"Pain Med"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1155\/2024\/1574798","article-title":"Effectiveness of resistance exercise for depression, fatigue, and sleep quality in women with fibromyalgia: a systematic review and meta-analysis","author":"Rodr\u00edguez-Dom\u00ednguez","year":"2024","journal-title":"Perspect Psychiatr 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