{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:28:15Z","timestamp":1770816495906,"version":"3.50.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Madelung\u2019s disease (MD) is a rare disorder of fat metabolism, with symptoms often characterized by the appearance of chronic accumulations of abnormal adipose tissue in areas such as the neck and neckline, upper back and chest. Nowadays, its pathogenesis is still unknown, and some scholars have suggested that its etiology is closely related to alcohol consumption, and that it is associated with a variety of metabolic diseases such as liver disease, hypertension, diabetes mellitus, dyslipidemia, and peripheral neurological damage. Currently, there are very few reported cases of Madelung\u2019s disease complicated by alcoholic liver disease and liver cirrhosis (LC), making this case worthy of reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summaries<\/jats:title>\n                    <jats:p>This article reports on a 60-year-old man, the main point of view \u201cThe patient has experienced edema in both lower limbs for 2 weeks, accompanied by a long history of alcohol consumption.\u201d Clinical examination showed subcutaneous swelling of the neck, which has been clearly present for three years. The diagnosis of Madelung\u2019s disease combined with alcoholic liver disease and liver cirrhosis was made based on laboratory tests of liver function, ultrasound of the neck vessels, ultrasound of the superficial tissues of the neck, and CT of the abdomen. The patient has not exhibited restricted neck mobility or symptoms of tracheoesophageal fat syndrome, which affects swallowing and breathing, and refused neck surgery treatment and received hepatoprotective therapy and traditional agents. After 14 days and two cycles of Chinese medicine, edema subsided, and the size of the subcutaneous mass remained stable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Madelung\u2019s disease is often underdiagnosed and misdiagnosed because of its low prevalence. The purpose of this article is to illustrate the need to be vigilant in clinical encounters with patients with Madelung\u2019s disease combined with alcoholic liver disease and liver cirrhosis, to achieve early intervention and treatment, and to prevent complications. The etiology of this disease remains unclear. Further research into its pathophysiological mechanisms should be pursued, opening new avenues for therapeutic investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.20251695921","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:28:16Z","timestamp":1763555296000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report of a patient with Madelung\u2019s disease combined with alcoholic liver disease and liver 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