{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:10Z","timestamp":1788415990938,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Type I cryoglobulinemia consists of a single monoclonal immunoglobulin and can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation, pathologically characterized by membranoproliferative glomerulonephritis (MPGN). In this report, we present a case of type I cryoglobulinemic renal injury characterized by crystalline cryoglobulinemic glomerulonephritis type I. Our objective is to provide a detailed insight into the presentation, underlying diseases, diagnosis, treatment, and outcomes of crystalline cryoglobulinemic glomerulonephritis type I.\n                      <jats:bold>Case presentation:<\/jats:bold>\n                      A 38-year-old man presented with acute kidney injury (AKI) without any other systemic symptoms. A kidney biopsy confirmed the presence of abundant pseudothrombi within the glomerular capillary lumens, with no significant proliferative lesions observed. Immunofluorescence microscopy (IF) demonstrated strong, diffuse, homogeneous staining for IgG\n                      <jats:sub>1<\/jats:sub>\n                      and Lambda light chain. Electron microscopy revealed a microtubular substructure characteristic of nephropathy. Following the initial course of rituximab, plasma exchange (PE), and methylprednisolone, the treatment yielded successful results. However, renal dysfunction recurred 18 months later, prompting a second renal biopsy, which exhibited findings similar to the first. Additionally, bone marrow biopsy identified an aberrant monotypic plasma cell clone. Subsequently, daratumumab therapy was initiated, leading to a recovery in kidney function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In nephropathies associated with crystalline cryoglobulinemic glomerulonephritis type I, renal and bone marrow biopsies play a crucial role in establishing the diagnosis and determining the optimal therapeutic approach. It is essential to consider primary diseases prior to selecting the initial management strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1667211","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:21:08Z","timestamp":1788412868000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute kidney injury secondary to crystalline cryoglobulinemic glomerulonephritis type I: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Aichun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Peking University People\u2019s Hospital","place":["Beijing, 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