{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T11:17:13Z","timestamp":1771931833977,"version":"3.50.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Refractory non-erosive gastroesophageal reflux disease (rNERD) involves complex interactions between esophageal sensitivity receptors (PAR2\/TRPV1) and persistent proton pump inhibitor (PPI)-refractory symptoms. This study exclusively employed radiofrequency ablation (RFA) as the uniform endoscopic intervention. All 20 enrolled rNERD patients underwent standardized RFA procedures; no participants underwent mucosal resection or ligation procedures. Post-intervention analysis demonstrated significant reductions in PAR2\/TRPV1 expression (PAR2: 81.8%\u202f\u2192\u202f35.5%; TRPV1: 1.6\u202f\u2192\u202f0.9 by Western blot) and inflammatory infiltration. Symptom improvement correlated with receptor downregulation (Reflux Symptom Index (RSI): 14.6\u202f\u2192\u202f5.0; Gastroesophageal Reflux Disease Questionnaire (GERD-Q): 14.0\u202f\u2192\u202f7.6). These findings indicate that endoscopic RFA alleviates rNERD symptoms through dual mechanisms: anatomical correction and esophageal hypersensitivity modulation via PAR2\/TRPV1 pathways.<\/jats:p>","DOI":"10.3389\/fmed.2026.1687564","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:38:25Z","timestamp":1770989905000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiofrequency ablation reduces esophageal hypersensitivity in refractory non-erosive reflux disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, College of Clinical Medicine, Hospital of Science and Technology","place":["Luoyang, Henan, China"]},{"name":"Henan Medical Key Laboratory of Gastrointestinal Microecology and Hepatology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, College of Clinical Medicine, Hospital of Science and Technology","place":["Luoyang, Henan, China"]},{"name":"Henan Medical Key Laboratory of Gastrointestinal Microecology and Hepatology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, College of Clinical Medicine, Hospital of Science and Technology","place":["Luoyang, Henan, China"]},{"name":"Henan Medical Key Laboratory of Gastrointestinal Microecology and Hepatology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingrui","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, College of Clinical Medicine, Hospital of Science and Technology","place":["Luoyang, Henan, China"]},{"name":"Henan Medical Key Laboratory of Gastrointestinal Microecology and Hepatology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Wen","sequence":"additional","affiliation":[{"name":"International Institute for Biomedical Biomaterials (I2BM)","place":["Zhengzhou, China"]},{"name":"Department of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University","place":["Richmond, VA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Mu","sequence":"additional","affiliation":[{"name":"The First 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