{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:04:59Z","timestamp":1773763499658,"version":"3.50.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastrointestinal dysfunction is a common complication of patients following laparoscopic surgery, prolonging recovery, and increasing healthcare costs. With Western medicine approaches having limitations, traditional Chinese medicine (TCM), particularly auricular therapy, has shown promise in managing this condition, previous research has lacked standardization in acupoint selection and has not fully utilized data mining techniques to uncover patterns in acupoint combinations. This study aims to conduct an exploratory analysis and pattern recognition through extensive literature review and data mining, thereby identifying common auricular acupuncture point patterns in laparoscopic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study systematically analyzed auricular therapy for gastrointestinal dysfunction after laparoscopic surgery. Data were retrieved from multiple Chinese and English databases up to April 30, 2025, using relevant search terms. Studies were filtered based on inclusion criteria and exclusion criteria. The included studies were standardized according to the Chinese national standard for auricular point nomenclature. Study information was organized using EndNote X9 and Excel 2021. Data underwent frequency analysis, association rule analysis, cluster analysis and network analysis to uncover patterns in acupoint selection and combinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 118 papers were included in the study, featuring 28 types of auricular points used 632 times. High-frequency points included Stomach, Large Intestine, and Small Intestine. Association rule analysis revealed 48 rules with lift values greater than 1, indicating significant correlations between certain acupoint combinations. Cluster analysis grouped the 28 auricular points into five clusters, while network analysis identified 12 strong connections between acupoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a systematic analysis of auricular acupoint selection patterns for gastrointestinal dysfunction after laparoscopic surgery, as the Stomach-Large Intestine-Sanjiao acupoints as the foundational protocol, Sympathetic-Shenmen as the synergistic module, and Spleen as the pivotal modulator for pattern differentiation. The findings highlight the potential of auricular therapy in this context and offer a reference for clinical practice. Future studies should further validate these type-specific patterns by expanding multi-center data sampling and integrating modern medical diagnostic techniques to enhance the reliability and applicability of the results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1708106","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:11:13Z","timestamp":1773756673000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Common auricular acupoint patterns for postoperative recovery across laparoscopic surgeries: a data mining-based systematic analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Guozhi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nursing, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nursing, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanglin","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuli","family":"Li","sequence":"additional","affiliation":[{"name":"Proctology Department, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqi","family":"She","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Nursing, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nursing, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine","place":["Zhongshan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3748\/wjg.v22.i2.704","article-title":"Laparoscopic colorectal surgery: current status and implementation of the latest technological innovations","volume":"22","author":"Pascual","year":"2016","journal-title":"World J Gastroenterol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e22246","DOI":"10.7759\/cureus.22246","article-title":"Recent technical developments in the field of laparoscopic surgery: a literature review","volume":"14","author":"Basunbul","year":"2022","journal-title":"Cureus."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.4240\/wjgs.v16.i5.1420","article-title":"Prognostic factors associated with gastrointestinal dysfunction after gastrointestinal tumor surgery: a meta-analysis","volume":"16","author":"Song","year":"2024","journal-title":"World J Gastrointest Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"zrad054","DOI":"10.1093\/bjsopen\/zrad054","article-title":"Global cost of postoperative ileus following abdominal surgery: meta-analysis","volume":"7","author":"Traeger","year":"2023","journal-title":"BJS Open"},{"key":"B5","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3760\/cma.j.cn115610-20230330-00141","article-title":"Health economic evaluation of patients with postoperative complications after colorectal surgery","volume":"22","author":"Wei","year":"2023","journal-title":"Chin J Dig Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1529347","DOI":"10.3389\/fcimb.2025.1529347","article-title":"Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine","volume":"15","author":"Zhang","year":"2025","journal-title":"Front Cell Infect Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s11695-024-07243-z","article-title":"Auricular acupressure in relieving PONV and promoting gastrointestinal function recovery in females after laparoscopic sleeve gastrectomy: a prospective randomized controlled trial","volume":"34","author":"Han","year":"2024","journal-title":"Obesity Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2478\/jtim-2022-0060","article-title":"Emerging noninvasive neuromodulation methods for functional gastrointestinal diseases","volume":"10","author":"Dz Chen","year":"2023","journal-title":"J Trans Intern Med."},{"key":"B9","first-page":"476","article-title":"Study on the intervention of auricular point therapy on gastrointestinal dysfunction after abdominal surgery","volume":"14","author":"Caihong","year":"2021","journal-title":"Chin J Crit Care Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S2468-1253(17)30253-4","article-title":"Neurostimulation for abdominal pain-related functional gastrointestinal disorders in adolescents: a randomised, double-blind, sham-controlled trial","volume":"2","author":"Kovacic","year":"2017","journal-title":"Lancet Gastroenterol Hepatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1016\/j.cgh.2019.10.012","article-title":"Efficacy of auricular neurostimulation in adolescents with irritable bowel syndrome in a randomized, double-blind trial","volume":"18","author":"Krasaelap","year":"2020","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.13702\/j.1000-0607.200665","article-title":"Effect characteristics and mechanism of acupuncture in autonomic nerve regulation","volume":"46","author":"Liu","year":"2021","journal-title":"Zhen ci yan jiu."},{"key":"B13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.13288\/j.11-2166\/r.2022.01.005","article-title":"Diagnosis and treatment of symptom overlap in functional gastrointestinal disorders based on the theory of regulating the middle and restoring balance","volume":"63","author":"Yongtian","year":"2022","journal-title":"J Tradit Chin Med."},{"key":"B14","first-page":"193","article-title":"The application of \u201cregulate sanjiao acupuncture\u201d in the treatment of gynecological diseases","volume":"39","author":"Dong","year":"2019","journal-title":"Zhongguo Zhen jiu."},{"key":"B15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0254-6272(13)60028-X","article-title":"Understanding the viscera-related theory that the lung and large intestine are exterior-interiorly related","volume":"32","author":"Ni","year":"2012","journal-title":"J Tradit Chin Med."},{"key":"B16","unstructured":"Nomenclature and Location of Auricular Points (GB\/T 13734-2008)\n          \n          2008"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e59241","DOI":"10.1371\/journal.pone.0059241","article-title":"Association rule mining and network analysis in oriental medicine","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS ONE."},{"key":"B18","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1093\/bib\/bbt074","article-title":"A primer to frequent itemset mining for bioinformatics","volume":"16","author":"Naulaerts","year":"2015","journal-title":"Brief Bioinform."},{"key":"B19","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1109\/RBME.2010.2083647","article-title":"Clustering algorithms in biomedical research: a review","volume":"3","author":"Xu","year":"2010","journal-title":"IEEE Rev Biomed Eng."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e150052","DOI":"10.1172\/jci.insight.150052","article-title":"Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation","volume":"6","author":"Shi","year":"2021","journal-title":"JCI Insight."},{"key":"B21","doi-asserted-by":"publisher","first-page":"521","DOI":"10.14309\/ajg.0000000000002548","article-title":"Transcutaneous auricular vagal nerve stimulation is effective for the treatment of functional dyspepsia: a multicenter, randomized controlled study","volume":"119","author":"Shi","year":"2024","journal-title":"Am J Gastroenterol."},{"key":"B22","first-page":"250","article-title":"The morphological changes of colonic submucusal plexus in rats of irritable bowel syndrome with diarrhea","volume":"30","author":"Shan","year":"2010","journal-title":"Chin J Digestion"},{"key":"B23","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1002\/biof.1097","article-title":"Substance P as a neuronal factor in the enteric nervous system of the porcine descending colon in physiological conditions and during selected pathogenic processes","volume":"39","author":"Gonkowski","year":"2013","journal-title":"BioFactors."},{"key":"B24","article-title":"Influence of electroacupuncture on substance P and vasoactive intestinal peptide in serum and tissues of functional diarrhea rats","author":"Yuan","year":"2012","journal-title":"J Guangzhou Univ Tradit Chin Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1053\/j.gastro.2020.09.030","article-title":"Sympathetic input to multiple cell types in mouse and human colon produces region-specific responses","volume":"160","author":"Smith-Edwards","year":"2021","journal-title":"Gastroenterology."},{"key":"B26","first-page":"947","article-title":"Clinical study of the combination of acupoint catgut-embedding therapy and auricular point pressure in the treatment of insomnia of spleen and stomach disharmony pattern","volume":"37","author":"Zhou","year":"2017","journal-title":"Zhongguo Zhen Jiu."},{"key":"B27","doi-asserted-by":"publisher","first-page":"115561","DOI":"10.1016\/j.fct.2025.115561","article-title":"Loperamide-induced constipation is associated with excessive accumulation of bile acids and cholesterol in the liver of mice; attenuation by hesperidin","volume":"203","author":"Li","year":"2025","journal-title":"Food Chem Toxicol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/S1875-5364(13)60019-9","article-title":"Wuling san ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice","volume":"11","author":"Ding","year":"2013","journal-title":"Chin J Nat Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41593-021-00811-x","article-title":"Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states","volume":"24","author":"Zhu","year":"2021","journal-title":"Nat Neurosci."},{"key":"B30","first-page":"249","article-title":"A study on the clinical efficacy of auricular pressure bean combined with twelve flavours of dandelion syrup on gastrointestinal function after gynaecological surgery","volume":"42","author":"Hou","year":"2020","journal-title":"J Inner Mong Med Univ."},{"key":"B31","first-page":"181","article-title":"Study on the mechanism of low-frequency auricular electric stimulation to reduce visceral hypersensitivity","author":"Wanli","year":"2021"},{"key":"B32","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrgastro.2012.168","article-title":"Regulation of gastrointestinal motility\u2013insights from smooth muscle biology","volume":"9","author":"Sanders","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1038\/s42255-023-00866-z","article-title":"Brain regulation of gastric dysfunction induced by stress","volume":"5","author":"Dong","year":"2023","journal-title":"Nat Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"6633","DOI":"10.1128\/AEM.01437-16","article-title":"Effects of proton pump inhibitors on the gastric mucosa-associated microbiota in dyspeptic patients","volume":"82","author":"Paroni Sterbini","year":"2016","journal-title":"Appl Environ Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1111\/apt.12052","article-title":"Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5-year follow-up in the LOTUS trial","volume":"36","author":"Fiocca","year":"2012","journal-title":"Aliment Pharmacol Therap."},{"key":"B36","doi-asserted-by":"publisher","first-page":"101472","DOI":"10.1016\/j.eclinm.2022.101472","article-title":"Effect of acupuncture on postoperative ileus after laparoscopic elective colorectal surgery: a prospective, randomised, controlled trial","volume":"49","author":"Yang","year":"2022","journal-title":"EClinicalMedicine."},{"key":"B37","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41586-020-2474-7","article-title":"Microbiota modulate sympathetic neurons via a gut-brain circuit","volume":"583","author":"Muller","year":"2020","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e14484","DOI":"10.1111\/nmo.14484","article-title":"Brain effect of transcutaneous vagal nerve stimulation: A meta-analysis of neuroimaging evidence","volume":"36","author":"Rajiah","year":"2024","journal-title":"Neurogastroenterol Motil."},{"key":"B39","first-page":"380","article-title":"Repairment effect of auricular electro-acupuncture on interstitial cells of Cajal in streptozotocin-induced diabetic rats","volume":"40","author":"Huan","year":"2020","journal-title":"J Nanjing Med Univ"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e0166638","DOI":"10.1371\/journal.pone.0166638","article-title":"The effects of auricular electro-acupuncture on ameliorating the dysfunction of interstitial cells of Cajal networks and nNOSmRNA expression in antrum of STZ-induced diabetic rats","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS ONE."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e14163","DOI":"10.1111\/nmo.14163","article-title":"Auricular vagal nerve stimulation enhances gastrointestinal motility and improves interstitial cells of Cajal in rats treated with loperamide","volume":"33","author":"Zhang","year":"2021","journal-title":"Neurogastroenterol Motil."},{"key":"B42","first-page":"53","article-title":"Effect of auricular plaster therapy combined with acupoint moxibustion on postoperativeabdominal distension in colorectal cancer patients","volume":"8","author":"Cuixia","year":"2022","journal-title":"J Clin Nurs Pract."},{"key":"B43","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.jopan.2024.08.005","article-title":"Effects of auricular acupressure on postoperative nausea and vomiting in patients with gynecological laparoscopic surgery: a randomized controlled trial","volume":"40","author":"Tsai","year":"2025","journal-title":"J Perianesth Nurs"},{"key":"B44","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3390\/biomedicines9080867","article-title":"Post-operative adhesions: a comprehensive review of mechanisms","volume":"9","author":"Fatehi Hassanabad","year":"2021","journal-title":"Biomedicines."},{"key":"B45","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/nmo.12693","article-title":"Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats","volume":"28","author":"Li","year":"2016","journal-title":"Neurogastroenterol Motil."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1426618","DOI":"10.3389\/fnins.2024.1426618","article-title":"Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application","volume":"18","author":"Guo","year":"2024","journal-title":"Front Neurosci."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1097\/HNP.0000000000000736","article-title":"Observation of the clinical effect of auricular acupressure in the treatment of insomnia: a singlecenter, single-arm, prospective study","author":"Ma","year":"2025","journal-title":"Holistic Nurs Pract."},{"key":"B48","first-page":"1892","article-title":"Effects of transcutaneous electrical stimulation of auricular Shenmen point on postoperative nausea and vomiting and patient-controlled epidural analgesia in cesarean section","volume":"92","author":"Li","year":"2012","journal-title":"Zhonghua yi xue za zhi."},{"key":"B49","first-page":"57","article-title":"Effect of traditional Chinese medicine nursing technique auricular point pressing pill on postoperative gastrointestinal function in elderly patients undergoing abdominal surgery","volume":"11","author":"Qiong","year":"2025","journal-title":"J Clin Nurs Pract"},{"key":"B50","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.3390\/cells11244103","article-title":"Vagus nerve stimulation: a personalized therapeutic approach for crohn's and other inflammatory bowel diseases","volume":"11","author":"Cirillo","year":"2022","journal-title":"Cells."},{"key":"B51","first-page":"108","article-title":"Clinical study on Shugan Paishi prescription combined with auricular acupoint pressing with beans for patients after surgery for hepatolithiasis","volume":"52","author":"Xuexiang","year":"2020","journal-title":"J New Chin Med."},{"key":"B52","first-page":"159","article-title":"Effect of auricular acupoint pressing combined with acupoint massage in the treatment of recovery of gastrointestinal function and secretion of brain gut peptide after gastric cancer surgery","volume":"58","author":"Fangyan","year":"2020","journal-title":"China Mod Doct."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1424304","DOI":"10.3389\/fendo.2024.1424304","article-title":"Auricular pressure as an adjuvant treatment for type 2 diabetes: data mining and meta-analysis","volume":"15","author":"Yu","year":"2024","journal-title":"Front Endocrinol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/pm\/pnz379","article-title":"Risks and safety of extended auricular therapy: a review of reviews and case reports of adverse events","volume":"21","author":"Nielsen","year":"2020","journal-title":"Pain Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41586-021-04001-4","article-title":"A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis","volume":"598","author":"Liu","year":"2021","journal-title":"Nature."},{"key":"B56","doi-asserted-by":"publisher","first-page":"945513","DOI":"10.3389\/fimmu.2022.945513","article-title":"Immune-inflammatory and hypothalamic-pituitary-adrenal axis biomarkers are altered in patients with non-specific low back pain: a systematic review","volume":"13","author":"Sanabria-Mazo","year":"2022","journal-title":"Front Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1006506","DOI":"10.3389\/fneph.2022.1006506","article-title":"Mechanisms underlying acupuncture therapy in chronic kidney disease: a narrative overview of preclinical studies and clinical trials","volume":"2","author":"Liu","year":"2022","journal-title":"Front Nephrol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"102490","DOI":"10.1016\/j.ejon.2023.102490","article-title":"Effectiveness of auricular acupuncture and pelvic floor muscle training in the management of urinary incontinence following surgical treatment for prostate cancer: a randomized clinical trial","volume":"68","author":"Azevedo","year":"2024","journal-title":"Eur J Oncol Nurs."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e35399","DOI":"10.1097\/MD.0000000000035399","article-title":"Noninvasive external therapy of traditional Chinese medicine for preventing postpartum urinary retention in women with vaginal delivery: a network meta-analysis","volume":"102","author":"Chen","year":"2023","journal-title":"Medicine."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e230127","DOI":"10.1148\/rg.230127","article-title":"Scintigraphy of gastrointestinal motility: best practices in assessment of gastric and bowel transit in adults","volume":"44","author":"Banks","year":"2024","journal-title":"Radiographics."},{"key":"B61","doi-asserted-by":"publisher","first-page":"102585","DOI":"10.1016\/j.compmedimag.2025.102585","article-title":"Three-step-guided visual prediction of glioblastoma recurrence from multimodality images","volume":"124","author":"Zhao","year":"2025","journal-title":"Comput Med Imaging Graph."},{"key":"B62","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut liver brain axis in diseases: the implications for therapeutic interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Signal Transduct Target Ther."},{"key":"B63","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13020-022-00649-w","article-title":"Acupuncture combined with auricular acupressure for smoking cessation and its effects on tobacco dependence and smoking behavior among Hong Kong smokers: a multicenter pilot clinical study","volume":"17","author":"Ho","year":"2022","journal-title":"Chin Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"107978","DOI":"10.1016\/j.pharmthera.2021.107978","article-title":"Probiotics: potential novel therapeutics for microbiota-gut-brain axis dysfunction across gender and lifespan","volume":"231","author":"Snigdha","year":"2022","journal-title":"Pharmacol Ther."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1708106\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:11:20Z","timestamp":1773756680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2026.1708106\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":64,"alternative-id":["10.3389\/fmed.2026.1708106"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2026.1708106","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]},"article-number":"1708106"}}