{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:16:34Z","timestamp":1771481794435,"version":"3.50.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The hemodynamic effects of red blood cell (RBC) transfusion in patients with hemato-oncologic diseases can be adverse. We measured acute hemodynamic changes with a novel non-invasive monitoring device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-six patients (9 female, 17 male; median age 73) with hematological malignancies or solid tumors were included. Peripheral and central hemodynamics were assessed before and after RBC transfusion using the VascAssist2.0 device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline hemoglobin was 7.8\u202fg\/dL (range 6.2\u20138.7). Post-transfusion, significant hemodynamic changes were observed: heart rate decreased from 81 to 74\u202fbpm (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001). Both brachial and aortic systolic and diastolic blood pressures increased significantly (brachial SBP: 123\u2013128\u202fmmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001; aortic SBP: 101\u2013109\u202fmmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0003; brachial DBP: 62\u201364\u202fmmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.01; aortic DBP: 61\u201364\u202fmmHg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.02). The augmentation index adjusted to 75\u202fbpm (AIx75) also rose significantly (11\u201318%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003). There were non-significant trends toward decreased aortic pulse wave velocity (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.09) and increased estimated blood viscosity (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.053), indicating possible beneficial rheological effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RBC transfusion in patients with hemato-oncologic diseases resulted in significant increases in central and peripheral blood pressures and a reduction in heart rate in our pilot study. Trends toward improved blood rheology and vascular function were observed, though not statistically significant. While these immediate hemodynamic effects appear beneficial, further research is needed to determine long-term outcomes, especially for patients requiring frequent transfusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1711829","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:24:18Z","timestamp":1771478658000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic effects of red blood cell transfusion in patients with hemato-oncologic diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Babak","family":"Yazdani","sequence":"first","affiliation":[{"name":"Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Pneumology), Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikoletta","family":"Schneider","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology, Pneumology), Faculty of Medicine of the University of Heidelberg, University Medical Center Mannheim UMM","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Abba","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical Faculty Mannheim, University Medical Centre Mannheim, Heidelberg University","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Schulz","sequence":"additional","affiliation":[{"name":"Harzklinikum Dorothea Christiane Erxleben - Klinikum Wernigerode, Klinik f\u00fcr Diagnostische und Interventionelle Radiologie","place":["Wernigerode, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Schumacher","sequence":"additional","affiliation":[{"name":"inmediQ GmbH","place":["Butzbach, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goekhan","family":"Yuecel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haemostaseology, and Medical Intensive Care, Medical Faculty Mannheim, University Medical Centre Mannheim, Heidelberg University","place":["Mannheim, Germany"]},{"name":"European Center for AngioScience (ECAS), German Centre for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, and Centre for Cardiovascular Acute Medicine Mannheim (ZKAM)","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf-Dieter","family":"Hofheinz","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical Faculty Mannheim, University Medical Centre Mannheim, Heidelberg University","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Duerschmied","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haemostaseology, and Medical Intensive Care, Medical Faculty Mannheim, University Medical Centre Mannheim, Heidelberg University","place":["Mannheim, Germany"]},{"name":"European Center for AngioScience (ECAS), German Centre for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, and Centre for Cardiovascular Acute Medicine Mannheim (ZKAM)","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Kayser","sequence":"additional","affiliation":[{"name":"Medical Faculty Mannheim, German Red Cross Blood Service Baden-W\u00fcrttemberg-Hessen, Institute of Transfusion Medicine and Immunology, Heidelberg University","place":["Mannheim, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hohneck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haemostaseology, and Medical Intensive Care, Medical Faculty Mannheim, University Medical Centre Mannheim, Heidelberg University","place":["Mannheim, Germany"]},{"name":"European Center for AngioScience (ECAS), German Centre for Cardiovascular Research (DZHK) partner site Heidelberg\/Mannheim, and Centre for Cardiovascular Acute Medicine Mannheim (ZKAM)","place":["Mannheim, Germany"]},{"name":"Department of Endocrinology, Diabetology, Metabolism and Clinical Chemistry, Heidelberg University Hospital and German Center for Diabetes Research (DZD) associated partner site Heidelberg","place":["Heidelberg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1423-0410.2009.01223.x","article-title":"Red blood cell transfusion in the treatment and management of anaemia: the search for the elusive transfusion trigger","volume":"98","author":"Wang","year":"2010","journal-title":"Vox Sang"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1537-2995.2003.00302.x","article-title":"Heart rate increases linearly in response to acute isovolemic anemia","volume":"43","author":"Weiskopf","year":"2003","journal-title":"Transfusion (Paris)"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1097\/00000542-200605000-00005","article-title":"Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans","volume":"104","author":"Weiskopf","year":"2006","journal-title":"Anesthesiology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1111\/j.1537-2995.2006.01026.x","article-title":"Clinical consequences of red cell storage in the critically ill","volume":"46","author":"Tinmouth","year":"2006","journal-title":"Transfusion (Paris)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"CD002042","DOI":"10.1002\/14651858.CD002042.pub5","article-title":"Transfusion thresholds for guiding red blood cell transfusion","volume":"12","author":"Carson","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1056\/NEJM199902113400601","article-title":"A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. 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