{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T06:37:43Z","timestamp":1777012663595,"version":"3.51.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Explore the clinical efficacy and safety of ciprofol-etomidate (C-E) versus propofol-etomidate (P-E) for gastrointestinal endoscopy sedation, and generate hypotheses for subsequent prospective pre-registered trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective, double-blind, randomized, positive-controlled exploratory trial enrolled 240 adults (120 per group). Exploratory outcomes included hemodynamics, adverse events, and Chalder Fatigue Questionnaire (CFQ) scores. Intention-to-treat (ITT) analysis was primary, with per-protocol analysis (PPA,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f223) as sensitivity validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      C-E group showed significantly lower CFQ Bimodal scores \u22654, postoperative dizziness incidence, and blood pressure fluctuations (&amp;gt;20% baseline; all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). One P-E patient needed respiratory support for SpO\u2082\u202f=\u202f85%. Other outcomes (e.g., induction time, total dose) were comparable. ITT and PPA results were consistent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This retrospective registered exploratory study tentatively suggests C-E may offer potential advantages in hemodynamic stability, respiratory safety, and reduced post-procedural fatigue\/dizziness for low-risk (ASA I\u202f~\u202fII) patients. Findings are hypothesis-generating and require validation via prospective pre-registered trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.chictr.org.cn\/indexEN.html<\/jats:uri>\n                      , identifier ChiCTR2500107221.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1714132","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:42:14Z","timestamp":1777009334000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ciprofol-etomidate versus propofol-etomidate for gastrointestinal endoscopy: a randomized, double-blind controlled clinical trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhen","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Wuxi No.2 People\u2019s Hospital (Affiliated Central Hospital of Jiangnan University)","place":["Wuxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Wuxi No.2 People\u2019s Hospital (Affiliated Central Hospital of Jiangnan University)","place":["Wuxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aolin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Wuxi No.2 People\u2019s Hospital (Affiliated Central Hospital of Jiangnan University)","place":["Wuxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Wuxi No.2 People\u2019s Hospital (Affiliated Central Hospital of Jiangnan University)","place":["Wuxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Wuxi No.2 People\u2019s Hospital (Affiliated Central Hospital of Jiangnan University)","place":["Wuxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Wuxi No.2 People\u2019s Hospital (Affiliated Central Hospital of Jiangnan University)","place":["Wuxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.gie.2017.07.018","article-title":"Guidelines for sedation and anesthesia in GI 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