{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:20:24Z","timestamp":1772090424106,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to develop a predictive model for ovarian endometrioma (OE) recurrence in patients with congenital obstructive M\u00fcllerian anomalies (OMAs) undergoing surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 139 OMA patients with histologically confirmed ovarian endometrioma undergoing complete lesion excision and anatomical reconstruction between January 2013 and December 2020. A multivariable Cox regression analysis identified recurrence predictors; a nomogram was constructed and validated via time-dependent receiver operating characteristic curve (ROC), calibration curve, and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean surgical age of 139 patients was 20.70\u202f\u00b1\u202f5.81\u202fyears. Over a mean follow-up of 80.8\u202fmonths, 29.5% of patients experienced OE recurrence. Cumulative recurrence rates were 1.4% (24\u202fmonths), 10.1% (36\u202fmonths), 27.1% (60\u202fmonths), and 34.4% (120\u202fmonths). In a multivariate analysis, independent risk factors for endometrioma recurrence, such as preoperative hematometra &amp;gt;5\u202fcm\n                      <jats:sup>3<\/jats:sup>\n                      (hazard ratio [HR]: 2.650, 95%CI: 1.356\u20135.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004), rASRM score &amp;gt;40 (HR: 3.488, 95%CI: 1.252\u20139.709,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.017), non-postoperative pregnancy (HR: 5.329, 95%CI: 1.399\u201320.307,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.014), and hormonal treatment \u226430\u202fmonths (HR: 3.563, 95%CI: 1.707\u20137.439,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001), and the other essential recurrent factor, surgical age, were all included in the nomogram. The nomogram showed strong discrimination (5-year AUC\u202f=\u202f0.862, 10-year AUC\u202f=\u202f0.808) and calibration, with decision curve analysis confirming clinical utility across probability thresholds. Internal validation via repeated K-fold cross-validation further showed robust model performance (5-year AUC\u202f=\u202f0.864, 10-year AUC\u202f=\u202f0.800).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This model effectively stratifies OE recurrence risk in OMA patients post-surgery, guiding personalized management. Early surgical intervention may optimize endometrioma recurrence prevention to relieve M\u00fcllerian duct obstruction combined with prolonged postoperative medical suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1714370","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:53:46Z","timestamp":1772088826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A predictive nomogram for postoperative ovarian endometrioma recurrence in patients with congenital obstructive M\u00fcllerian anomalies: a retrospective study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaotong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keqin","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Obstetrics and Gynecology Hospital of Fudan University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.jmig.2017.04.020","article-title":"Obstructive reproductive tract anomalies: a review of 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