{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:51:07Z","timestamp":1780091467110,"version":"3.54.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the clinical features and chest computed tomography (CT) findings in 42 patients with\n                      <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                      pneumonia, as confirmed by metagenomic next-generation sequencing (mNGS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective analysis of clinical data and chest CT findings (both at disease onset and within 1\u202fmonth thereafter) in 42 patients diagnosed with\n                      <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                      pneumonia by mNGS at our hospital between August 2022 and August 2025.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 42 patients, 25 (59.5%) presented with fever, 26 (61.9%) with sore throat, 30 (71.4%) with cough, 27 (64.3%) with expectoration, 11 (26.2%) with myalgia, 10 (23.8%) with general fatigue, and 10 (23.8%) with neurological symptoms such as headache and dizziness. Laboratory tests revealed that 12 patients (28.6%) showed a mild increase in white blood cell count, 10 (23.8%) had elevated neutrophil counts, 21 (50.0%) exhibited elevated C-reactive protein (CRP) levels, and 6 (14.3%) had CRP levels exceeding 100\u202fmg\/L. In the early stage, chest CT demonstrated a lobular pneumonia pattern in 16 patients (55.2%), involvement of a single lung lobe in 20 (69.0%), predominant lower-lung distribution in 19 (65.5%), and a nodular-patchy pattern in 8 patients (27.6%) with a nodular\u2013patchy pattern. The main accompanying features included a halo sign in 25 patients (86.2%), centrilobular nodules in 23 (79.3%), and bronchial wall thickening in 20 (69.0%). In the mid-to-late stage, chest CT revealed a lobular pneumonia pattern in 23 patients (76.7%), single-lobe involvement in 23 (76.7%), and predominant lower-lung distribution in 20 (66.7%). The major concomitant features were a halo sign in 21 patients (70.0%), centrilobular nodules in 20 (66.7%), and bronchial wall thickening in 24 (80.0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Chest CT findings of\n                      <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                      pneumonia are predominantly characterized by a lobular pneumonia pattern, lower-lobe distribution, and associated features such as bronchial wall thickening, centrilobular nodules, and a peripheral halo sign. Certain imaging differences exist between early and middle-to-late stages, with the nodular-patchy pattern potentially representing an ultra-early imaging marker, which may provide clues for early clinical intervention.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1717744","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:39:05Z","timestamp":1769495945000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical features and chest CT findings of Chlamydia pneumoniae pneumonia"],"prefix":"10.3389","volume":"13","author":[{"given":"Haoyu","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology, Sichuan Provincial Corps Hospital, Chinese People\u2019s Armed Police Forces","place":["Leshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelei","family":"QuBie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial Corps Hospital, Chinese People\u2019s Armed Police Forces","place":["Leshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial Corps Hospital, Chinese People\u2019s Armed Police Forces","place":["Leshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial Corps Hospital, Chinese People\u2019s Armed Police Forces","place":["Leshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sichuan Provincial Corps Hospital, Chinese People\u2019s Armed Police Forces","place":["Leshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"002006","DOI":"10.1099\/jmm.0.002006","article-title":"From coughs to complications: the story of Chlamydia pneumoniae","volume":"74","author":"Tagini","year":"2025","journal-title":"J Med Microbiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1007\/s10096-025-05244-z","article-title":"Sharp increase in Chlamydia pneumoniae infections in 2024 in Germany","volume":"44","author":"Boutin","year":"","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3201\/eid3004.231610","article-title":"Chlamydia pneumoniae upsurge at tertiary hospital, Lausanne, Switzerland","volume":"30","author":"Tagini","year":"2024","journal-title":"Emerg 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