{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:08:15Z","timestamp":1771571295193,"version":"3.50.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer-related fever is a common complication of lung cancer that negatively affects patients\u2019 quality of life. Recently, Qing-Hao-Bie-Jia Decoction (QHBJD), as a representative Traditional Chinese Medicine (TCM) formula historically used to treat endogenous heat caused by Yin deficiency, has been increasingly applied in the management of lung cancer-related fever (LCRF). Our investigation endeavored to establish a chain of evidence bridging classical TCM theory and contemporary clinical practice toward the application of QHBJD in treating LCRF as a methodological reference in the real-world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our study was made up of three parts: 1) Ancient origins of QHBJD from pre-modern Chinese medical texts; 2) systematic review of QHBJD for treating LCRF from published case reports; 3) a case report treated with QHBJD-derived supplementary formula from our clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From our findings, \u201clatent heat in the Yin\u201d is the predominant pathogenesis of cancerous fever among lung cancer patients, who are mainly treated with the therapeutic principle of nourishing Yin and outthrusting heat. In addition, the pathogenesis of included LCRF case reports is complicated, but TCM practitioners can support vital-qi and eliminate pathogenic factors by flexibly adding or subtracting Chinese medicines based on QHBJD for treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, we established a methodological framework merging ancient and modern evidence based on case reports, which prospectively aids future TCM studies in enhancing certainty of the same evidence from empirical medicine to evidence-based medicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1717877","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:41:00Z","timestamp":1771569660000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Using supplementary formula of Qing-Hao-Bie-Jia decoction for defervescence of lung cancer-related fever: a literature review and case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiao-Ge","family":"Chu","sequence":"first","affiliation":[{"name":"Hematology Department, Shanghai Beizhan Hospital","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Department, Institute of Oncology Shanghai Municipal Hospital of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Man","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Xin","family":"Han","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3322\/caac.21731","article-title":"Cancer treatment and survivorship statistics","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.19656\/j.cnki.1002-2406.20221012.","article-title":"Discussion on pathogenesis and treatment of cancerous fever based on release of fire stagnation","volume":"39","author":"Wu","year":"2022","journal-title":"Inform Tradit Chin Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1007\/s00520-005-0825-4","article-title":"Neoplastic fever: a neglected paraneoplastic syndrome","volume":"13","author":"Zell","year":"2005","journal-title":"Support Care 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