{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:41:58Z","timestamp":1771623718714,"version":"3.50.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Project of Tianjin Municipal Health Commission","award":["2023013"],"award-info":[{"award-number":["2023013"]}]},{"name":"Tianjin Science and Technology Program of China","award":["21JCYBJC01590"],"award-info":[{"award-number":["21JCYBJC01590"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Abdominal compartment syndrome (ACS) is a life-threatening condition typically associated with trauma, major surgery, or acute abdominal pathology. Its occurrence in oncology patients, particularly as a complication of chemotherapy-induced gastrointestinal mucositis, is exceedingly rare. This report presents a unique case of ACS triggered by mucosal injury following chemotherapy, complicated by septic shock and multiorgan failure, in a patient with lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 64-year-old male with lung cancer underwent platinum-etoposide chemotherapy. Following his fourth cycle, he developed bowel dysmotility and was administered a laxative, which precipitated profuse watery diarrhea. Within hours, he experienced progressive abdominal distension, nausea, vomiting, and hemodynamic instability. Laboratory tests revealed severe metabolic acidosis, hyperlactatemia, and pancytopenia. Imaging showed massive gastrointestinal fluid retention and elevated intra-abdominal pressure (IAP). Blood cultures confirmed ESBL-producing\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      bacteremia. The patient was admitted to the intensive care unit and received mechanical ventilation, vasopressors, continuous renal replacement therapy, gastrointestinal decompression, and broad-spectrum antibiotics. IAP peaked at 28\u202fmmHg, fulfilling criteria for ACS. With multidisciplinary management, including PiCCO-guided hemodynamic optimization and targeted antimicrobial therapy, the patient\u2019s condition gradually improved. He was extubated on day 17 and discharged from the intensive care unit on day 19.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates a rare but critical pathway from chemotherapy-induced mucosal injury to ACS, mediated by enterogenic sepsis and systemic inflammation. Early recognition, continuous IAP monitoring, and aggressive supportive care are essential for survival. Clinicians should maintain a high index of suspicion for ACS in immunocompromised oncology patients presenting with abdominal symptoms and septic physiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1718333","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:32:20Z","timestamp":1768545140000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Abdominal compartment syndrome following chemotherapy-induced gastrointestinal mucositis: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Tian-le","family":"Li","sequence":"first","affiliation":[{"name":"Heart Center, Central Hospital, Tianjin University\/Tianjin Third Central Hospital","place":["Tianjin, China"]},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Nankai University Affinity the Third Central Hospital","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Nankai University Affinity the Third Central Hospital","place":["Tianjin, China"]},{"name":"Department of Critical Care Medicine, Central Hospital, Tianjin University\/Tianjin Third Central Hospital","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Nankai University Affinity the Third Central Hospital","place":["Tianjin, China"]},{"name":"Department of Emergency, Central Hospital, Tianjin University\/Tianjin Third Central Hospital","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wei","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Nankai University Affinity the Third Central Hospital","place":["Tianjin, China"]},{"name":"Ward General Practice, Central Hospital, Tianjin University\/Tianjin Third Central Hospital","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Heart Center, Central Hospital, Tianjin University\/Tianjin Third Central Hospital","place":["Tianjin, China"]},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Nankai University Affinity the Third Central Hospital","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1007\/s00134-013-2906-z","article-title":"Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome","volume":"39","author":"Kirkpatrick","year":"2013","journal-title":"Intensive Care Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1097\/mcc.0000000000000991","article-title":"Intra-abdominal hypertension and abdominal compartment syndrome","volume":"28","author":"De 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