{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:05:58Z","timestamp":1787663158033,"version":"build-2736575974"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Peking University Hepatology Institute Qi-Min Project"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304215"],"award-info":[{"award-number":["82304215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Scientific Research Development Funds","award":["RS2024-06"],"award-info":[{"award-number":["RS2024-06"]}]},{"name":"Peking University People\u2019s Hospital Scientific Research Development Funds","award":["RDL2024-06"],"award-info":[{"award-number":["RDL2024-06"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the predictors and prognostic impact of sarcopenic obesity (Sa-O) on all-cause mortality in patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included cirrhosis patients. Sa-O was defined using computed tomography at L3 level as a skeletal muscle index &amp;lt;42\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      or &amp;lt;38\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      \/m\n                      <jats:sup>2<\/jats:sup>\n                      in men and women, respectively, with a visceral adipose tissue area &amp;gt;100\u202fcm\n                      <jats:sup>2<\/jats:sup>\n                      . The primary outcome was all-cause mortality. A nomograph was developed based on identified predictors, generating the age\u2013body mass index (BMI)\u2013alcohol\u2013hypertension (ABAH) score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 769 cirrhosis patients (60.1% male; 45.5% aged \u226560\u202fyears; median follow-up: 4.3 [1.7\u20137.0] years), 129 (16.8%) were diagnosed with Sa-O. Multivariable analysis identified age (OR [odds ratio] 1.813, 95% confidence interval [CI] 1.210\u20132.718,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0040), BMI\u202f\u2265\u202f28\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (OR 0.076, 95% CI 0.018\u20130.317,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0011), alcoholic liver disease (OR 1.685, 95% CI 1.078\u20132.634,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0220), and hypertension (OR 1.801, 95% CI 1.184\u20132.739,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0059) as independent predictors of Sa-O. As for BMI (OR 0.076), the limitations of BMI in reflecting body composition led to the counterintuitive research findings. When stratified by ABAH score into low (&amp;lt;100), medium (100\u2013129), and high (\u2265130) score groups, patients demonstrated progressively higher rates of Sa-O (8.4, 18.7, and 30.5%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.026). The prognostic value of the ABAH score was analyzed using a Cox proportional hazards model by subgroups analysis. It showed significant prognostic value for all-cause mortality, with medium-score patients exhibiting a 1.53-fold increased risk (95% CI 1.12\u20132.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.007) and high-score patients a 1.72-fold increased risk (95% CI 1.22\u20132.42,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.002) compared to the low-score reference group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sa-O in patients with cirrhosis is associated with age, BMI, alcoholic liver disease, and hypertension. The newly developed ABAH score, a composite clinical risk marker, predicted the probability of Sa-O and was associated with all-cause mortality in patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1719899","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:55:01Z","timestamp":1769064901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A simple score of sarcopenic obesity predicts all-cause mortality in patients with cirrhosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuteng","family":"Yang","sequence":"first","affiliation":[{"name":"Peking University People\u2019s Hospital","place":["Beijing, China"]},{"name":"School of Basic Medical Sciences, Peking University Health Science Center","place":["Beijing, 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Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjie","family":"Tie","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital","place":["Beijing, China"]},{"name":"School of Basic Medical Sciences, Peking University Health Science Center","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Harbin Pingfang District People's Hospital","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danli","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Infectious Disease and Hepatology Center of Peking University People's Hospital, Peking University Hepatology Institute, Peking University People's Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Jin","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Infectious Disease and Hepatology Center of Peking University People's Hospital, Peking University Hepatology Institute, Peking University People's Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Infectious Disease and Hepatology Center of Peking University People's Hospital, Peking University Hepatology Institute, Peking University People's Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Infectious Disease and Hepatology Center of Peking University People's Hospital, Peking University Hepatology Institute, Peking University People's Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Infectious Disease and Hepatology Center of Peking University People's Hospital, Peking University Hepatology Institute, Peking University People's Hospital","place":["Beijing, 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