{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:07:41Z","timestamp":1770138461909,"version":"3.49.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>The COVID-19 pandemic profoundly disrupted social structures, psychological well-being, and lifestyle behaviors, yet the collective impact on steatotic liver disease (SLD) and fibrosis remains unclear. This study aimed to examine whether the relationships of social, psychosocial, and behavioral factors with metabolic dysfunction\u2013associated SLD (MASLD), metabolic alcohol-related liver disease (MetALD), ALD, and liver fibrosis varied across pandemic periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a repeated cross-sectional analysis of 6,090 adults from the National Health and Nutrition Examination Survey (NHANES) 2017\u2013March 2020 (pre-pandemic) and 2021\u20132023 (pandemic), using vibration-controlled transient elastography and comprehensive social, psychosocial, and lifestyle measures. Weighted prevalence and Firth\u2019s logistic regression assessed associations and pandemic interactions via ratios of odds ratios (RORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age-standardized MASLD prevalence declined from 32.2% to 28.6%, especially among men, whereas advanced fibrosis nearly doubled from 2.6% to 4.2%, mainly in women. Pandemic-period interactions revealed substantial shifts in risk profiles. Higher income lost its pre-pandemic protective association with MetALD (ROR\u202f=\u202f0.21), while unemployment increased MetALD risk in women. Depressive symptoms strengthened ALD risk in men during the pandemic (OR\u202f=\u202f5.31; ROR\u202f=\u202f6.73), but became less relevant for MetALD, particularly among women. Physical activity, which was previously protective for MASLD and ALD, lost significance post-pandemic. Current smoking markedly amplified ALD risk (OR rising from 3.49 to 17.08), whereas former smoking provided protection against MASLD in men. Dietary inflammation (DII) became inversely associated with fibrosis during the pandemic, and longer weekend sleep offered protective benefits for women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The pandemic period was associated with substantial changes in the epidemiology and psychosocial\u2013behavioral correlates of SLD and fibrosis, with notable sex-specific differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2026.1725338","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:30:09Z","timestamp":1770100209000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of the COVID-19 pandemic on liver health: exploring shifts in social and psychosocial determinants of steatosis and fibrosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanhui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiacheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yikun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Second Hospital of Shanxi Medical University, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1016\/j.cgh.2025.02.006","article-title":"High global prevalence of Steatotic liver disease and associated subtypes: a meta-analysis","volume":"23","author":"Ho","year":"2025","journal-title":"Clin Gastroenterol 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